Comparison of intra- and postoperative analgesia and pain perception in robot-assisted vs. open radical prostatectomy
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Comparison of intra- and postoperative analgesia and pain perception in robot-assisted vs. open radical prostatectomy. / Knipper, Sophie; Hagedorn, Moritz; Sadat-Khonsari, Maryam; Tian, Zhe; Karakiewicz, Pierre I; Tilki, Derya; Heinzer, Hans; Michl, Uwe; Steuber, Thomas; von Breunig, Franziska; Zöllner, Christian; Graefen, Markus.
In: WORLD J UROL, Vol. 38, No. 6, 06.2020, p. 1451-1457.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Comparison of intra- and postoperative analgesia and pain perception in robot-assisted vs. open radical prostatectomy
AU - Knipper, Sophie
AU - Hagedorn, Moritz
AU - Sadat-Khonsari, Maryam
AU - Tian, Zhe
AU - Karakiewicz, Pierre I
AU - Tilki, Derya
AU - Heinzer, Hans
AU - Michl, Uwe
AU - Steuber, Thomas
AU - von Breunig, Franziska
AU - Zöllner, Christian
AU - Graefen, Markus
PY - 2020/6
Y1 - 2020/6
N2 - PURPOSE: One of the advantages of minimally invasive surgery may be reduced postoperative pain and faster recovery. However, reliable comparisons of robot-assisted (RARP) vs. open radical prostatectomy (ORP) addressing perioperative pain regimen are scarce.METHODS: We identified 420 consecutive treated patients who underwent RARP (n = 254) vs. ORP (n = 166) for clinically localized prostate cancer in 2017. After 1:1 propensity score matching for age, body mass index, D'Amico risk classification and lymph node yield, intra- and postoperative pain medication doses, as well as pain perception expressed by the numeric rating scale were assessed in uni- and multivariable analyses.RESULTS: Median age was 64.9 years. Operation time was significantly shorter in ORP patients (155 vs. 175 min in RARP, p < 0.001). Overall, a median of 12.5 vs. 12 g of metamizol was administered in RARP vs. ORP patients (p = 0.2). Additionally, a median of 146.7 vs. 133.9 mg of morphine equivalent was administered in RARP vs. ORP patients (p < 0.001). The mean maximum pain perceived on day 0 was 3.2 vs. 3.6 in RARP vs. ORP patients (p = 0.1). It decreased within the following days, and again, no differences between the two groups were observed. All results were confirmed in multivariable analyses.CONCLUSIONS: When comparing RARP vs. ORP, a small increase in perioperative morphine administration at RARP may be expected. However, when assessing pain perception, no differences were observed between the two groups. Moreover, mean maximum pain perceived was very low, which may reassure patients, who are counselled for radical prostatectomy.
AB - PURPOSE: One of the advantages of minimally invasive surgery may be reduced postoperative pain and faster recovery. However, reliable comparisons of robot-assisted (RARP) vs. open radical prostatectomy (ORP) addressing perioperative pain regimen are scarce.METHODS: We identified 420 consecutive treated patients who underwent RARP (n = 254) vs. ORP (n = 166) for clinically localized prostate cancer in 2017. After 1:1 propensity score matching for age, body mass index, D'Amico risk classification and lymph node yield, intra- and postoperative pain medication doses, as well as pain perception expressed by the numeric rating scale were assessed in uni- and multivariable analyses.RESULTS: Median age was 64.9 years. Operation time was significantly shorter in ORP patients (155 vs. 175 min in RARP, p < 0.001). Overall, a median of 12.5 vs. 12 g of metamizol was administered in RARP vs. ORP patients (p = 0.2). Additionally, a median of 146.7 vs. 133.9 mg of morphine equivalent was administered in RARP vs. ORP patients (p < 0.001). The mean maximum pain perceived on day 0 was 3.2 vs. 3.6 in RARP vs. ORP patients (p = 0.1). It decreased within the following days, and again, no differences between the two groups were observed. All results were confirmed in multivariable analyses.CONCLUSIONS: When comparing RARP vs. ORP, a small increase in perioperative morphine administration at RARP may be expected. However, when assessing pain perception, no differences were observed between the two groups. Moreover, mean maximum pain perceived was very low, which may reassure patients, who are counselled for radical prostatectomy.
U2 - 10.1007/s00345-019-02938-w
DO - 10.1007/s00345-019-02938-w
M3 - SCORING: Journal article
C2 - 31493108
VL - 38
SP - 1451
EP - 1457
JO - WORLD J UROL
JF - WORLD J UROL
SN - 0724-4983
IS - 6
ER -