Comparison of different non-invasive methods for detection of allergic asthma
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Comparison of different non-invasive methods for detection of allergic asthma. / Raulf-Heimsoth, M; van Kampen, V; Heinze, E; Bernard, S; Borowitzki, G; Freundt, S; Sucker, K; Eliakopoulos, C; Nienhaus, A; Brüning, T; Merget, R.
RESPIRATORY REGULATION - CLINICAL ADVANCES. Vol. 755 Springer, 2013. p. 55-63 (Advances in Experimental Medicine and Biology).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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T1 - Comparison of different non-invasive methods for detection of allergic asthma
AU - Raulf-Heimsoth, M
AU - van Kampen, V
AU - Heinze, E
AU - Bernard, S
AU - Borowitzki, G
AU - Freundt, S
AU - Sucker, K
AU - Eliakopoulos, C
AU - Nienhaus, A
AU - Brüning, T
AU - Merget, R
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Non-invasive methods to assess inflammation of lower airways are induced sputum (IS), exhaled nitric oxide (eNO), and exhaled breath condensate (EBC). Here we focused on the assessment of airway inflammation with a panel of non-invasive methods in health care workers (HCWs) with suspected latex allergy with and without current allergic respiratory symptoms about 10 years after the latex ban in German health care facilities. Seventy-seven non-smoking subjects were examined by skin prick test and specific IgE measurements, eNO, IS, and EBC. Sensitivity, specificity, and positive and negative predicted values for relevant biomarkers were calculated using current asthma symptoms as the gold standard. Twenty-nine subjects (38%) reported ongoing asthmatic symptoms (AS). In these subjects the EBC concentrations of nitrogen oxides (NO(x); p=0.027) and leukotriene B(4) (p=0.025) were significantly higher than in subjects without AS. In addition, in the subjects with AS the numbers of eosinophils (p=0.015) and the concentrations of IL-5 (p= 0.021) in IS samples were significantly higher than in the subjects without AS. A good correlation between several inflammatory markers in IS was detected. The maximum Youden Index was reached for IS total eosinophils ≥3.5·10(4) with a test efficiency of 0.72. In conclusion, non-invasive inflammatory monitoring with EBC and IS may assist the diagnosis of allergic asthma. Self-reported current asthmatic symptoms were reflected by eosinophilic inflammation and the best parameter to support the asthma diagnosis is a total number of eosinophils ≥3.5·10(4) in IS.
AB - Non-invasive methods to assess inflammation of lower airways are induced sputum (IS), exhaled nitric oxide (eNO), and exhaled breath condensate (EBC). Here we focused on the assessment of airway inflammation with a panel of non-invasive methods in health care workers (HCWs) with suspected latex allergy with and without current allergic respiratory symptoms about 10 years after the latex ban in German health care facilities. Seventy-seven non-smoking subjects were examined by skin prick test and specific IgE measurements, eNO, IS, and EBC. Sensitivity, specificity, and positive and negative predicted values for relevant biomarkers were calculated using current asthma symptoms as the gold standard. Twenty-nine subjects (38%) reported ongoing asthmatic symptoms (AS). In these subjects the EBC concentrations of nitrogen oxides (NO(x); p=0.027) and leukotriene B(4) (p=0.025) were significantly higher than in subjects without AS. In addition, in the subjects with AS the numbers of eosinophils (p=0.015) and the concentrations of IL-5 (p= 0.021) in IS samples were significantly higher than in the subjects without AS. A good correlation between several inflammatory markers in IS was detected. The maximum Youden Index was reached for IS total eosinophils ≥3.5·10(4) with a test efficiency of 0.72. In conclusion, non-invasive inflammatory monitoring with EBC and IS may assist the diagnosis of allergic asthma. Self-reported current asthmatic symptoms were reflected by eosinophilic inflammation and the best parameter to support the asthma diagnosis is a total number of eosinophils ≥3.5·10(4) in IS.
KW - Adult
KW - Asthma
KW - Breath Tests
KW - Female
KW - Health Personnel
KW - Humans
KW - Immunoglobulin E
KW - Leukotriene B4
KW - Male
KW - Nitric Oxide
KW - Skin Tests
U2 - 10.1007/978-94-007-4546-9_7
DO - 10.1007/978-94-007-4546-9_7
M3 - SCORING: Contribution to collected editions/anthologies
C2 - 22826049
SN - 978-94-007-4545-2
SN - 978-94-007-4546-9
VL - 755
T3 - Advances in Experimental Medicine and Biology
SP - 55
EP - 63
BT - RESPIRATORY REGULATION - CLINICAL ADVANCES
PB - Springer
ER -