Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome

TY - JOUR

T1 - Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome

AU - Bannas, P

AU - Rybczynski, M

AU - Sheikhzadeh, S

AU - Kodolitsch, Yskert

AU - Derlin, T

AU - Yamamura, J

AU - Lund, G

AU - Adam, G

AU - Groth, M

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2015/6/22

Y1 - 2015/6/22

N2 - Purpose: Patients with Marfan syndrome require repeated imaging for monitoring of aortic root aneurysms. Therefore, we evaluated the agreement and reproducibility of cine-MRI and echocardiography measurements of the sinuses of Valsalva in patients with suspected Marfan syndrome. Materials and Methods: 51 consecutive patients with suspected Marfan syndrome were prospectively examined using cine-MRI and echocardiography. Two readers independently measured aortic root diameters at the level of the sinuses of Valsalva in both cine-MRI and echocardiography. Statistics included intraclass correlation coefficient, Pearson correlation coefficient, Bland-Altman analysis, and two-sided t-test. Results: In 38 of the 51 individuals (74.5 %), the diagnosis of Marfan syndrome was established according to the criteria of the Ghent-2 nosology. Cine-MRI measurements of the sinuses of Valsalva revealed a strong correlation with echocardiography (r = 0.929), but a statistically significant bias of -1.0 mm (p < 0.001). The mean absolute diameter for sinuses of Valsalva obtained by cine-MRI was 32.3 ± 5.8 mm as compared to 33.4 ± 5.4 mm obtained by echocardiography. Interobserver agreement of measurements of the sinuses of Valsalva was higher for cine-MRI than for echocardiography (p = 0.029). Conclusion: Despite small, but statistically significant differences in terms of agreement and reproducibility, cine-MRI and echocardiographic measurements of aortic root diameters provide comparable results without a significant clinical difference. Therefore both techniques may be used for monitoring of the aortic root in patients with Marfan syndrome. Key points: • Cine-MRI (ICC: 0.93, CI: 0.88 - 0.96) and echocardiography (ICC: 0.90, CI: 0.82 - 0.94) allow assessment of aortic root diameters in patients with Marfan syndrome• Cine-MRI offers higher reproducibility of aortic root diameters than echocardiography (95 % limits of agreement of ± 3.6 mm versus ± 5.0 mm, p = 0.029)• Aortic root measurements with cine-MRI and echocardiography reveal a small (mean difference; -1.0 mm) but statistically significant offset (p = 0.0004) Citation Format: • Bannas P., Rybczynski M., Sheikhzadeh S. et al. Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome. Fortschr Röntgenstr 2015; DOI: 10.1055/s-0035-1553224.

AB - Purpose: Patients with Marfan syndrome require repeated imaging for monitoring of aortic root aneurysms. Therefore, we evaluated the agreement and reproducibility of cine-MRI and echocardiography measurements of the sinuses of Valsalva in patients with suspected Marfan syndrome. Materials and Methods: 51 consecutive patients with suspected Marfan syndrome were prospectively examined using cine-MRI and echocardiography. Two readers independently measured aortic root diameters at the level of the sinuses of Valsalva in both cine-MRI and echocardiography. Statistics included intraclass correlation coefficient, Pearson correlation coefficient, Bland-Altman analysis, and two-sided t-test. Results: In 38 of the 51 individuals (74.5 %), the diagnosis of Marfan syndrome was established according to the criteria of the Ghent-2 nosology. Cine-MRI measurements of the sinuses of Valsalva revealed a strong correlation with echocardiography (r = 0.929), but a statistically significant bias of -1.0 mm (p < 0.001). The mean absolute diameter for sinuses of Valsalva obtained by cine-MRI was 32.3 ± 5.8 mm as compared to 33.4 ± 5.4 mm obtained by echocardiography. Interobserver agreement of measurements of the sinuses of Valsalva was higher for cine-MRI than for echocardiography (p = 0.029). Conclusion: Despite small, but statistically significant differences in terms of agreement and reproducibility, cine-MRI and echocardiographic measurements of aortic root diameters provide comparable results without a significant clinical difference. Therefore both techniques may be used for monitoring of the aortic root in patients with Marfan syndrome. Key points: • Cine-MRI (ICC: 0.93, CI: 0.88 - 0.96) and echocardiography (ICC: 0.90, CI: 0.82 - 0.94) allow assessment of aortic root diameters in patients with Marfan syndrome• Cine-MRI offers higher reproducibility of aortic root diameters than echocardiography (95 % limits of agreement of ± 3.6 mm versus ± 5.0 mm, p = 0.029)• Aortic root measurements with cine-MRI and echocardiography reveal a small (mean difference; -1.0 mm) but statistically significant offset (p = 0.0004) Citation Format: • Bannas P., Rybczynski M., Sheikhzadeh S. et al. Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome. Fortschr Röntgenstr 2015; DOI: 10.1055/s-0035-1553224.

U2 - 10.1055/s-0035-1553224

DO - 10.1055/s-0035-1553224

M3 - SCORING: Journal article

C2 - 26098252

VL - 187

SP - 1022

EP - 1028

JO - ROFO-FORTSCHR RONTG

JF - ROFO-FORTSCHR RONTG

SN - 1438-9029

IS - 11

ER -