Research ExplorerPublicationsComparing the chemical biology of NO and HNO

Comparing the chemical biology of NO and HNO

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Comparing the chemical biology of NO and HNO. / Flores-Santana, Wilmarie; Switzer, Christopher; Ridnour, Lisa A; Basudhar, Debashree; Mancardi, Daniele; Donzelli, Sonia; Thomas, Douglas D; Miranda, Katrina M; Fukuto, Jon M; Wink, David A.

In: ARCH PHARM RES, Vol. 32, No. 8, 01.08.2009, p. 1139-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Flores-Santana, W, Switzer, C, Ridnour, LA, Basudhar, D, Mancardi, D, Donzelli, S, Thomas, DD, Miranda, KM, Fukuto, JM & Wink, DA 2009, 'Comparing the chemical biology of NO and HNO', ARCH PHARM RES, vol. 32, no. 8, pp. 1139-53. https://doi.org/10.1007/s12272-009-1805-x

APA

Flores-Santana, W., Switzer, C., Ridnour, L. A., Basudhar, D., Mancardi, D., Donzelli, S., Thomas, D. D., Miranda, K. M., Fukuto, J. M., & Wink, D. A. (2009). Comparing the chemical biology of NO and HNO. ARCH PHARM RES, 32(8), 1139-53. https://doi.org/10.1007/s12272-009-1805-x

Vancouver

Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S et al. Comparing the chemical biology of NO and HNO. ARCH PHARM RES. 2009 Aug 1;32(8):1139-53. https://doi.org/10.1007/s12272-009-1805-x

Bibtex

@article{8f908c7800514f259e218f3a1c1cfe01,
title = "Comparing the chemical biology of NO and HNO",
abstract = "For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many researchers have reported important signaling pathways as well as mechanisms of action of these species, showing direct and indirect effects depending on the environment. Both NO and HNO can react with, among others, metals, proteins, thiols and heme proteins via unique and distinct chemistry leading to improvement of some clinical conditions. Understanding the basic chemistry of NO and HNO and distinguishing their mechanisms of action as well as methods of detection are crucial for understanding the current and potential clinical applications. In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions.",
keywords = "Animals, Humans, Nitric Oxide, Nitrogen Oxides, Reactive Nitrogen Species",
author = "Wilmarie Flores-Santana and Christopher Switzer and Ridnour, {Lisa A} and Debashree Basudhar and Daniele Mancardi and Sonia Donzelli and Thomas, {Douglas D} and Miranda, {Katrina M} and Fukuto, {Jon M} and Wink, {David A}",
year = "2009",
month = aug,
day = "1",
doi = "10.1007/s12272-009-1805-x",
language = "English",
volume = "32",
pages = "1139--53",
journal = "ARCH PHARM RES",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "8",

}

RIS

TY - JOUR

T1 - Comparing the chemical biology of NO and HNO

AU - Flores-Santana, Wilmarie

AU - Switzer, Christopher

AU - Ridnour, Lisa A

AU - Basudhar, Debashree

AU - Mancardi, Daniele

AU - Donzelli, Sonia

AU - Thomas, Douglas D

AU - Miranda, Katrina M

AU - Fukuto, Jon M

AU - Wink, David A

PY - 2009/8/1

Y1 - 2009/8/1

N2 - For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many researchers have reported important signaling pathways as well as mechanisms of action of these species, showing direct and indirect effects depending on the environment. Both NO and HNO can react with, among others, metals, proteins, thiols and heme proteins via unique and distinct chemistry leading to improvement of some clinical conditions. Understanding the basic chemistry of NO and HNO and distinguishing their mechanisms of action as well as methods of detection are crucial for understanding the current and potential clinical applications. In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions.

AB - For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many researchers have reported important signaling pathways as well as mechanisms of action of these species, showing direct and indirect effects depending on the environment. Both NO and HNO can react with, among others, metals, proteins, thiols and heme proteins via unique and distinct chemistry leading to improvement of some clinical conditions. Understanding the basic chemistry of NO and HNO and distinguishing their mechanisms of action as well as methods of detection are crucial for understanding the current and potential clinical applications. In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions.

KW - Animals

KW - Humans

KW - Nitric Oxide

KW - Nitrogen Oxides

KW - Reactive Nitrogen Species

U2 - 10.1007/s12272-009-1805-x

DO - 10.1007/s12272-009-1805-x

M3 - SCORING: Journal article

C2 - 19727606

VL - 32

SP - 1139

EP - 1153

JO - ARCH PHARM RES

JF - ARCH PHARM RES

SN - 0253-6269

IS - 8

ER -