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Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany

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Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany. / Nakel, Jacqueline; Robitaille, Alexis; Günther, Thomas; Rosenau, Lorenz; Czech-Sioli, Manja; Plenge-Bönig, Anita; Bühler, Silja; Wille, Andreas; Jakubowski, Elke; Pruskil, Susanne; Wahlen, Manuela; Indenbirken, Daniela; Nörz, Dominik; Lütgehetmann, Marc; Aepfelbacher, Martin; Grundhoff, Adam; Grolle, Benjamin; Fischer, Nicole.

In: INT J HYG ENVIR HEAL, Vol. 240, 113928, 03.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nakel, J, Robitaille, A, Günther, T, Rosenau, L, Czech-Sioli, M, Plenge-Bönig, A, Bühler, S, Wille, A, Jakubowski, E, Pruskil, S, Wahlen, M, Indenbirken, D, Nörz, D, Lütgehetmann, M, Aepfelbacher, M, Grundhoff, A, Grolle, B & Fischer, N 2022, 'Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany', INT J HYG ENVIR HEAL, vol. 240, 113928. https://doi.org/10.1016/j.ijheh.2022.113928

APA

Nakel, J., Robitaille, A., Günther, T., Rosenau, L., Czech-Sioli, M., Plenge-Bönig, A., Bühler, S., Wille, A., Jakubowski, E., Pruskil, S., Wahlen, M., Indenbirken, D., Nörz, D., Lütgehetmann, M., Aepfelbacher, M., Grundhoff, A., Grolle, B., & Fischer, N. (2022). Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany. INT J HYG ENVIR HEAL, 240, [113928]. https://doi.org/10.1016/j.ijheh.2022.113928

Vancouver

Nakel J, Robitaille A, Günther T, Rosenau L, Czech-Sioli M, Plenge-Bönig A et al. Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany. INT J HYG ENVIR HEAL. 2022 Mar;240. 113928. https://doi.org/10.1016/j.ijheh.2022.113928

Bibtex

@article{8def746f1ac7455cb2e9588f4555afbf,
title = "Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany",
abstract = "We describe two outbreaks of SARS-CoV-2 in daycare centers in the metropolitan area of Hamburg, Germany. The outbreaks occurred in rapid chronological succession, in neighborhoods with a very similar sociodemographic structure, thus allowing for cross-comparison of these events. We combined classical and molecular epidemiologic investigation methods to study infection entry, spread within the facilities, and subsequent transmission of infections to households. Epidemiologic and molecular evidence suggests a superspreading event with a non-variant of concern (non-VOC) SARS CoV-2 strain at the root of the first outbreak. The second outbreak involved two childcare facilities experiencing infection activity with the variant of concern (VOC) B.1.1.7 (Alpha). We show that the index cases in all outbreaks had been childcare workers, and that children contributed substantially to secondary transmission of SARS-CoV-2 infection from childcare facilities to households. The frequency of secondary transmissions in households originating from B.1.1.7-infected children was increased compared to children with non-VOC infections. Self-reported symptoms, particularly cough and rhinitis, occurred more frequently in B.1.1.7-infected children. Especially in light of the rapidly spreading VOC B.1.617.2 (Delta), our data underline the notion that rigorous SARS-CoV-2 testing in combination with screening of contacts regardless of symptoms is an important measure to prevent SARS-CoV-2 infection of unvaccinated individuals in daycare centers and associated households.",
keywords = "COVID-19/diagnosis, COVID-19 Testing, Child, Child Day Care Centers, Disease Outbreaks, Germany/epidemiology, Humans, SARS-CoV-2",
author = "Jacqueline Nakel and Alexis Robitaille and Thomas G{\"u}nther and Lorenz Rosenau and Manja Czech-Sioli and Anita Plenge-B{\"o}nig and Silja B{\"u}hler and Andreas Wille and Elke Jakubowski and Susanne Pruskil and Manuela Wahlen and Daniela Indenbirken and Dominik N{\"o}rz and Marc L{\"u}tgehetmann and Martin Aepfelbacher and Adam Grundhoff and Benjamin Grolle and Nicole Fischer",
note = "Copyright {\textcopyright} 2022 Elsevier GmbH. All rights reserved.",
year = "2022",
month = mar,
doi = "10.1016/j.ijheh.2022.113928",
language = "English",
volume = "240",
journal = "INT J HYG ENVIR HEAL",
issn = "1438-4639",
publisher = "Urban und Fischer Verlag Jena",

}

RIS

TY - JOUR

T1 - Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany

AU - Nakel, Jacqueline

AU - Robitaille, Alexis

AU - Günther, Thomas

AU - Rosenau, Lorenz

AU - Czech-Sioli, Manja

AU - Plenge-Bönig, Anita

AU - Bühler, Silja

AU - Wille, Andreas

AU - Jakubowski, Elke

AU - Pruskil, Susanne

AU - Wahlen, Manuela

AU - Indenbirken, Daniela

AU - Nörz, Dominik

AU - Lütgehetmann, Marc

AU - Aepfelbacher, Martin

AU - Grundhoff, Adam

AU - Grolle, Benjamin

AU - Fischer, Nicole

N1 - Copyright © 2022 Elsevier GmbH. All rights reserved.

PY - 2022/3

Y1 - 2022/3

N2 - We describe two outbreaks of SARS-CoV-2 in daycare centers in the metropolitan area of Hamburg, Germany. The outbreaks occurred in rapid chronological succession, in neighborhoods with a very similar sociodemographic structure, thus allowing for cross-comparison of these events. We combined classical and molecular epidemiologic investigation methods to study infection entry, spread within the facilities, and subsequent transmission of infections to households. Epidemiologic and molecular evidence suggests a superspreading event with a non-variant of concern (non-VOC) SARS CoV-2 strain at the root of the first outbreak. The second outbreak involved two childcare facilities experiencing infection activity with the variant of concern (VOC) B.1.1.7 (Alpha). We show that the index cases in all outbreaks had been childcare workers, and that children contributed substantially to secondary transmission of SARS-CoV-2 infection from childcare facilities to households. The frequency of secondary transmissions in households originating from B.1.1.7-infected children was increased compared to children with non-VOC infections. Self-reported symptoms, particularly cough and rhinitis, occurred more frequently in B.1.1.7-infected children. Especially in light of the rapidly spreading VOC B.1.617.2 (Delta), our data underline the notion that rigorous SARS-CoV-2 testing in combination with screening of contacts regardless of symptoms is an important measure to prevent SARS-CoV-2 infection of unvaccinated individuals in daycare centers and associated households.

AB - We describe two outbreaks of SARS-CoV-2 in daycare centers in the metropolitan area of Hamburg, Germany. The outbreaks occurred in rapid chronological succession, in neighborhoods with a very similar sociodemographic structure, thus allowing for cross-comparison of these events. We combined classical and molecular epidemiologic investigation methods to study infection entry, spread within the facilities, and subsequent transmission of infections to households. Epidemiologic and molecular evidence suggests a superspreading event with a non-variant of concern (non-VOC) SARS CoV-2 strain at the root of the first outbreak. The second outbreak involved two childcare facilities experiencing infection activity with the variant of concern (VOC) B.1.1.7 (Alpha). We show that the index cases in all outbreaks had been childcare workers, and that children contributed substantially to secondary transmission of SARS-CoV-2 infection from childcare facilities to households. The frequency of secondary transmissions in households originating from B.1.1.7-infected children was increased compared to children with non-VOC infections. Self-reported symptoms, particularly cough and rhinitis, occurred more frequently in B.1.1.7-infected children. Especially in light of the rapidly spreading VOC B.1.617.2 (Delta), our data underline the notion that rigorous SARS-CoV-2 testing in combination with screening of contacts regardless of symptoms is an important measure to prevent SARS-CoV-2 infection of unvaccinated individuals in daycare centers and associated households.

KW - COVID-19/diagnosis

KW - COVID-19 Testing

KW - Child

KW - Child Day Care Centers

KW - Disease Outbreaks

KW - Germany/epidemiology

KW - Humans

KW - SARS-CoV-2

U2 - 10.1016/j.ijheh.2022.113928

DO - 10.1016/j.ijheh.2022.113928

M3 - SCORING: Journal article

C2 - 35093719

VL - 240

JO - INT J HYG ENVIR HEAL

JF - INT J HYG ENVIR HEAL

SN - 1438-4639

M1 - 113928

ER -