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Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study

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Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study. / Brehm, Thomas Theo; Heyer, Andreas; Woo, Marcel S; Fischer, Marlene; van der Meirschen, Marc; Wichmann, Dominic; Jarczak, Dominik; Roedl, Kevin; Schmiedel, Stefan; Addo, Marylyn M; Lütgehetmann, Marc; Christner, Martin; Huber, Samuel; Lohse, Ansgar W; Kluge, Stefan; Schulze Zur Wiesch, Julian.

In: J INFECT PUBLIC HEAL, Vol. 16, No. 11, 11.2023, p. 1806-1812.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brehm, TT, Heyer, A, Woo, MS, Fischer, M, van der Meirschen, M, Wichmann, D, Jarczak, D, Roedl, K, Schmiedel, S, Addo, MM, Lütgehetmann, M, Christner, M, Huber, S, Lohse, AW, Kluge, S & Schulze Zur Wiesch, J 2023, 'Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study', J INFECT PUBLIC HEAL, vol. 16, no. 11, pp. 1806-1812. https://doi.org/10.1016/j.jiph.2023.08.010

APA

Brehm, T. T., Heyer, A., Woo, M. S., Fischer, M., van der Meirschen, M., Wichmann, D., Jarczak, D., Roedl, K., Schmiedel, S., Addo, M. M., Lütgehetmann, M., Christner, M., Huber, S., Lohse, A. W., Kluge, S., & Schulze Zur Wiesch, J. (2023). Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study. J INFECT PUBLIC HEAL, 16(11), 1806-1812. https://doi.org/10.1016/j.jiph.2023.08.010

Vancouver

Brehm TT, Heyer A, Woo MS, Fischer M, van der Meirschen M, Wichmann D et al. Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study. J INFECT PUBLIC HEAL. 2023 Nov;16(11):1806-1812. https://doi.org/10.1016/j.jiph.2023.08.010

Bibtex

@article{a768d236720e437993f8d08fbb032b52,
title = "Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study",
abstract = "BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity.METHODS: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022.RESULTS: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic.CONCLUSIONS: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system.",
author = "Brehm, {Thomas Theo} and Andreas Heyer and Woo, {Marcel S} and Marlene Fischer and {van der Meirschen}, Marc and Dominic Wichmann and Dominik Jarczak and Kevin Roedl and Stefan Schmiedel and Addo, {Marylyn M} and Marc L{\"u}tgehetmann and Martin Christner and Samuel Huber and Lohse, {Ansgar W} and Stefan Kluge and {Schulze Zur Wiesch}, Julian",
note = "Copyright {\textcopyright} 2023. Published by Elsevier Ltd.",
year = "2023",
month = nov,
doi = "10.1016/j.jiph.2023.08.010",
language = "English",
volume = "16",
pages = "1806--1812",
journal = "J INFECT PUBLIC HEAL",
issn = "1876-0341",
publisher = "Elsevier BV",
number = "11",

}

RIS

TY - JOUR

T1 - Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study

AU - Brehm, Thomas Theo

AU - Heyer, Andreas

AU - Woo, Marcel S

AU - Fischer, Marlene

AU - van der Meirschen, Marc

AU - Wichmann, Dominic

AU - Jarczak, Dominik

AU - Roedl, Kevin

AU - Schmiedel, Stefan

AU - Addo, Marylyn M

AU - Lütgehetmann, Marc

AU - Christner, Martin

AU - Huber, Samuel

AU - Lohse, Ansgar W

AU - Kluge, Stefan

AU - Schulze Zur Wiesch, Julian

N1 - Copyright © 2023. Published by Elsevier Ltd.

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity.METHODS: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022.RESULTS: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic.CONCLUSIONS: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system.

AB - BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity.METHODS: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022.RESULTS: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic.CONCLUSIONS: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system.

U2 - 10.1016/j.jiph.2023.08.010

DO - 10.1016/j.jiph.2023.08.010

M3 - SCORING: Journal article

C2 - 37741015

VL - 16

SP - 1806

EP - 1812

JO - J INFECT PUBLIC HEAL

JF - J INFECT PUBLIC HEAL

SN - 1876-0341

IS - 11

ER -