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Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

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Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. / Childs, Erica J; Mocci, Evelina; Campa, Daniele; Bracci, Paige M; Gallinger, Steven; Goggins, Michael; Li, Donghui; Neale, Rachel E; Olson, Sara H; Scelo, Ghislaine; Amundadottir, Laufey T; Bamlet, William R; Bijlsma, Maarten F; Blackford, Amanda; Borges, Michael; Brennan, Paul; Brenner, Hermann; Bueno-de-Mesquita, H Bas; Canzian, Federico; Capurso, Gabriele; Cavestro, Giulia M; Chaffee, Kari G; Chanock, Stephen J; Cleary, Sean P; Cotterchio, Michelle; Foretova, Lenka; Fuchs, Charles; Funel, Niccola; Gazouli, Maria; Hassan, Manal; Herman, Joseph M; Holcatova, Ivana; Holly, Elizabeth A; Hoover, Robert N; Hung, Rayjean J; Janout, Vladimir; Key, Timothy J; Kupcinskas, Juozas; Kurtz, Robert C; Landi, Stefano; Lu, Lingeng; Malecka-Panas, Ewa; Mambrini, Andrea; Mohelnikova-Duchonova, Beatrice; Neoptolemos, John P; Oberg, Ann L; Orlow, Irene; Pasquali, Claudio; Pezzilli, Raffaele; Rizzato, Cosmeri; Saldia, Amethyst; Scarpa, Aldo; Stolzenberg-Solomon, Rachael Z; Strobel, Oliver; Tavano, Francesca; Vashist, Yogesh K; Vodicka, Pavel; Wolpin, Brian M; Yu, Herbert; Petersen, Gloria M; Risch, Harvey A; Klein, Alison P.

In: NAT GENET, Vol. 47, No. 8, 08.2015, p. 911-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Childs, EJ, Mocci, E, Campa, D, Bracci, PM, Gallinger, S, Goggins, M, Li, D, Neale, RE, Olson, SH, Scelo, G, Amundadottir, LT, Bamlet, WR, Bijlsma, MF, Blackford, A, Borges, M, Brennan, P, Brenner, H, Bueno-de-Mesquita, HB, Canzian, F, Capurso, G, Cavestro, GM, Chaffee, KG, Chanock, SJ, Cleary, SP, Cotterchio, M, Foretova, L, Fuchs, C, Funel, N, Gazouli, M, Hassan, M, Herman, JM, Holcatova, I, Holly, EA, Hoover, RN, Hung, RJ, Janout, V, Key, TJ, Kupcinskas, J, Kurtz, RC, Landi, S, Lu, L, Malecka-Panas, E, Mambrini, A, Mohelnikova-Duchonova, B, Neoptolemos, JP, Oberg, AL, Orlow, I, Pasquali, C, Pezzilli, R, Rizzato, C, Saldia, A, Scarpa, A, Stolzenberg-Solomon, RZ, Strobel, O, Tavano, F, Vashist, YK, Vodicka, P, Wolpin, BM, Yu, H, Petersen, GM, Risch, HA & Klein, AP 2015, 'Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer', NAT GENET, vol. 47, no. 8, pp. 911-6. https://doi.org/10.1038/ng.3341

APA

Childs, E. J., Mocci, E., Campa, D., Bracci, P. M., Gallinger, S., Goggins, M., Li, D., Neale, R. E., Olson, S. H., Scelo, G., Amundadottir, L. T., Bamlet, W. R., Bijlsma, M. F., Blackford, A., Borges, M., Brennan, P., Brenner, H., Bueno-de-Mesquita, H. B., Canzian, F., ... Klein, A. P. (2015). Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. NAT GENET, 47(8), 911-6. https://doi.org/10.1038/ng.3341

Vancouver

Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M et al. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. NAT GENET. 2015 Aug;47(8):911-6. https://doi.org/10.1038/ng.3341

Bibtex

@article{f814433be1a641989764d170cd8767e1,
title = "Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer",
abstract = "Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk.",
keywords = "Aged, Australia, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 7, Europe, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, North America, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Risk Factors",
author = "Childs, {Erica J} and Evelina Mocci and Daniele Campa and Bracci, {Paige M} and Steven Gallinger and Michael Goggins and Donghui Li and Neale, {Rachel E} and Olson, {Sara H} and Ghislaine Scelo and Amundadottir, {Laufey T} and Bamlet, {William R} and Bijlsma, {Maarten F} and Amanda Blackford and Michael Borges and Paul Brennan and Hermann Brenner and Bueno-de-Mesquita, {H Bas} and Federico Canzian and Gabriele Capurso and Cavestro, {Giulia M} and Chaffee, {Kari G} and Chanock, {Stephen J} and Cleary, {Sean P} and Michelle Cotterchio and Lenka Foretova and Charles Fuchs and Niccola Funel and Maria Gazouli and Manal Hassan and Herman, {Joseph M} and Ivana Holcatova and Holly, {Elizabeth A} and Hoover, {Robert N} and Hung, {Rayjean J} and Vladimir Janout and Key, {Timothy J} and Juozas Kupcinskas and Kurtz, {Robert C} and Stefano Landi and Lingeng Lu and Ewa Malecka-Panas and Andrea Mambrini and Beatrice Mohelnikova-Duchonova and Neoptolemos, {John P} and Oberg, {Ann L} and Irene Orlow and Claudio Pasquali and Raffaele Pezzilli and Cosmeri Rizzato and Amethyst Saldia and Aldo Scarpa and Stolzenberg-Solomon, {Rachael Z} and Oliver Strobel and Francesca Tavano and Vashist, {Yogesh K} and Pavel Vodicka and Wolpin, {Brian M} and Herbert Yu and Petersen, {Gloria M} and Risch, {Harvey A} and Klein, {Alison P}",
year = "2015",
month = aug,
doi = "10.1038/ng.3341",
language = "English",
volume = "47",
pages = "911--6",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

AU - Childs, Erica J

AU - Mocci, Evelina

AU - Campa, Daniele

AU - Bracci, Paige M

AU - Gallinger, Steven

AU - Goggins, Michael

AU - Li, Donghui

AU - Neale, Rachel E

AU - Olson, Sara H

AU - Scelo, Ghislaine

AU - Amundadottir, Laufey T

AU - Bamlet, William R

AU - Bijlsma, Maarten F

AU - Blackford, Amanda

AU - Borges, Michael

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Bueno-de-Mesquita, H Bas

AU - Canzian, Federico

AU - Capurso, Gabriele

AU - Cavestro, Giulia M

AU - Chaffee, Kari G

AU - Chanock, Stephen J

AU - Cleary, Sean P

AU - Cotterchio, Michelle

AU - Foretova, Lenka

AU - Fuchs, Charles

AU - Funel, Niccola

AU - Gazouli, Maria

AU - Hassan, Manal

AU - Herman, Joseph M

AU - Holcatova, Ivana

AU - Holly, Elizabeth A

AU - Hoover, Robert N

AU - Hung, Rayjean J

AU - Janout, Vladimir

AU - Key, Timothy J

AU - Kupcinskas, Juozas

AU - Kurtz, Robert C

AU - Landi, Stefano

AU - Lu, Lingeng

AU - Malecka-Panas, Ewa

AU - Mambrini, Andrea

AU - Mohelnikova-Duchonova, Beatrice

AU - Neoptolemos, John P

AU - Oberg, Ann L

AU - Orlow, Irene

AU - Pasquali, Claudio

AU - Pezzilli, Raffaele

AU - Rizzato, Cosmeri

AU - Saldia, Amethyst

AU - Scarpa, Aldo

AU - Stolzenberg-Solomon, Rachael Z

AU - Strobel, Oliver

AU - Tavano, Francesca

AU - Vashist, Yogesh K

AU - Vodicka, Pavel

AU - Wolpin, Brian M

AU - Yu, Herbert

AU - Petersen, Gloria M

AU - Risch, Harvey A

AU - Klein, Alison P

PY - 2015/8

Y1 - 2015/8

N2 - Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk.

AB - Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk.

KW - Aged

KW - Australia

KW - Chromosomes, Human, Pair 17

KW - Chromosomes, Human, Pair 2

KW - Chromosomes, Human, Pair 3

KW - Chromosomes, Human, Pair 7

KW - Europe

KW - Female

KW - Gene Frequency

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - North America

KW - Pancreatic Neoplasms

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

U2 - 10.1038/ng.3341

DO - 10.1038/ng.3341

M3 - SCORING: Journal article

C2 - 26098869

VL - 47

SP - 911

EP - 916

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 8

ER -