Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy."

A Soave; S Riethdorf; R Dahlem; S Minner; L Weisbach; O Engel; M Fisch; K Pantel; M Rink

doi:10.1016/j.urolonc.2018.05.013

Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy."

Standard

Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy.". / Soave, A ; Riethdorf, S ; Dahlem, R ; Minner, S; Weisbach, L; Engel, O; Fisch, M ; Pantel, K; Rink, M.

In: UROL ONCOL-SEMIN ORI, Vol. 36, No. 7, 07.2018, p. 347-348.

Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

Harvard

Soave, A , Riethdorf, S , Dahlem, R , Minner, S, Weisbach, L, Engel, O, Fisch, M , Pantel, K & Rink, M 2018, 'Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy."', UROL ONCOL-SEMIN ORI, vol. 36, no. 7, pp. 347-348. https://doi.org/10.1016/j.urolonc.2018.05.013

APA

Soave, A., Riethdorf, S., Dahlem, R., Minner, S., Weisbach, L., Engel, O., Fisch, M., Pantel, K., & Rink, M. (2018). Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy.". UROL ONCOL-SEMIN ORI, 36(7), 347-348. https://doi.org/10.1016/j.urolonc.2018.05.013

Vancouver

Soave A , Riethdorf S , Dahlem R , Minner S, Weisbach L, Engel O et al. Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy.". UROL ONCOL-SEMIN ORI. 2018 Jul;36(7):347-348. https://doi.org/10.1016/j.urolonc.2018.05.013

Bibtex

@article{22ca4e449ce9440c8a11d657cf7d15db,

title = "Commentary on {"}Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy.{"}",

abstract = "OBJECTIVES: To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes.PATIENTS AND METHODS: We, prospectively, collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7.5ml) were analyzed for CTC using the CellSearch system (Janssen, Raritan, NJ).RESULTS: Variant UCB histology was found in 47 patients (25.0%), most frequently of squamous cell differentiation (16.5%). CTC were present in 30 patients (21.3%) and 12 patients (25.5%) with pure and variant UCB histology, respectively. At a median follow-up of 25 months, the presence of CTC and nonsquamous cell differentiation were associated with reduced recurrence-free survival (RFS) and cancer-specific survival (pairwise P ≤ 0.016). Patients without CTC had better RFS, independent of UCB histology, than patients with CTC with any UCB histology (pairwise P<0.05). In multivariable analyses, the presence of CTC, but not variant UCB histology, was an independent predictor for disease recurrence (hazard ratio = 3.45, P<0.001) and cancer-specific mortality (hazard ratio = 2.62, P = 0.002).CONCLUSION: CTC are detectable in about a quarter of patients with pure or variant UCB histology before RC, and represent an independent predictor for outcomes, when adjusting for histological subtype. In addition, our prospective data confirm the unfavorable influence of nonsquamous cell-differentiated UCB on outcomes.",

keywords = "Carcinoma, Transitional Cell, Cystectomy, Humans, Neoplasm Recurrence, Local, Neoplastic Cells, Circulating, Prospective Studies, Retrospective Studies, Treatment Outcome, Urinary Bladder Neoplasms, Journal Article, Comment",

author = "A Soave and S Riethdorf and R Dahlem and S Minner and L Weisbach and O Engel and M Fisch and K Pantel and M Rink",

note = "Comment",

year = "2018",

month = jul,

doi = "10.1016/j.urolonc.2018.05.013",

language = "English",

volume = "36",

pages = "347--348",

journal = "UROL ONCOL-SEMIN ORI",

issn = "1078-1439",

publisher = "Elsevier Inc.",

number = "7",

}

RIS

TY - JOUR

T1 - Commentary on "Detection and oncological effect of circulating tumor cells in patients with variant urothelial carcinoma histology treated with radical cystectomy."

AU - Soave, A

AU - Riethdorf, S

AU - Dahlem, R

AU - Minner, S

AU - Weisbach, L

AU - Engel, O

AU - Fisch, M

AU - Pantel, K

AU - Rink, M

N1 - Comment

PY - 2018/7

Y1 - 2018/7

N2 - OBJECTIVES: To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes.PATIENTS AND METHODS: We, prospectively, collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7.5ml) were analyzed for CTC using the CellSearch system (Janssen, Raritan, NJ).RESULTS: Variant UCB histology was found in 47 patients (25.0%), most frequently of squamous cell differentiation (16.5%). CTC were present in 30 patients (21.3%) and 12 patients (25.5%) with pure and variant UCB histology, respectively. At a median follow-up of 25 months, the presence of CTC and nonsquamous cell differentiation were associated with reduced recurrence-free survival (RFS) and cancer-specific survival (pairwise P ≤ 0.016). Patients without CTC had better RFS, independent of UCB histology, than patients with CTC with any UCB histology (pairwise P<0.05). In multivariable analyses, the presence of CTC, but not variant UCB histology, was an independent predictor for disease recurrence (hazard ratio = 3.45, P<0.001) and cancer-specific mortality (hazard ratio = 2.62, P = 0.002).CONCLUSION: CTC are detectable in about a quarter of patients with pure or variant UCB histology before RC, and represent an independent predictor for outcomes, when adjusting for histological subtype. In addition, our prospective data confirm the unfavorable influence of nonsquamous cell-differentiated UCB on outcomes.

AB - OBJECTIVES: To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes.PATIENTS AND METHODS: We, prospectively, collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7.5ml) were analyzed for CTC using the CellSearch system (Janssen, Raritan, NJ).RESULTS: Variant UCB histology was found in 47 patients (25.0%), most frequently of squamous cell differentiation (16.5%). CTC were present in 30 patients (21.3%) and 12 patients (25.5%) with pure and variant UCB histology, respectively. At a median follow-up of 25 months, the presence of CTC and nonsquamous cell differentiation were associated with reduced recurrence-free survival (RFS) and cancer-specific survival (pairwise P ≤ 0.016). Patients without CTC had better RFS, independent of UCB histology, than patients with CTC with any UCB histology (pairwise P<0.05). In multivariable analyses, the presence of CTC, but not variant UCB histology, was an independent predictor for disease recurrence (hazard ratio = 3.45, P<0.001) and cancer-specific mortality (hazard ratio = 2.62, P = 0.002).CONCLUSION: CTC are detectable in about a quarter of patients with pure or variant UCB histology before RC, and represent an independent predictor for outcomes, when adjusting for histological subtype. In addition, our prospective data confirm the unfavorable influence of nonsquamous cell-differentiated UCB on outcomes.

KW - Carcinoma, Transitional Cell

KW - Cystectomy

KW - Humans

KW - Neoplasm Recurrence, Local

KW - Neoplastic Cells, Circulating

KW - Prospective Studies

KW - Retrospective Studies

KW - Treatment Outcome

KW - Urinary Bladder Neoplasms

KW - Journal Article

KW - Comment

U2 - 10.1016/j.urolonc.2018.05.013

DO - 10.1016/j.urolonc.2018.05.013

M3 - Other (editorial matter etc.)

C2 - 29880457

VL - 36

SP - 347

EP - 348

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 7

ER -