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Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement.

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Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement. / Fröschle, G; Zieron, J O; Carl, U M; Beck-Bornholdt, Hans-Peter.

In: RADIOTHER ONCOL, Vol. 46, No. 3, 3, 1998, p. 317-320.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fröschle, G, Zieron, JO, Carl, UM & Beck-Bornholdt, H-P 1998, 'Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement.', RADIOTHER ONCOL, vol. 46, no. 3, 3, pp. 317-320. <http://www.ncbi.nlm.nih.gov/pubmed/9572625?dopt=Citation>

APA

Fröschle, G., Zieron, J. O., Carl, U. M., & Beck-Bornholdt, H-P. (1998). Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement. RADIOTHER ONCOL, 46(3), 317-320. [3]. http://www.ncbi.nlm.nih.gov/pubmed/9572625?dopt=Citation

Vancouver

Fröschle G, Zieron JO, Carl UM, Beck-Bornholdt H-P. Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement. RADIOTHER ONCOL. 1998;46(3):317-320. 3.

Bibtex

@article{f50dd1548b2340e1998bf960fa4f2aa0,
title = "Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement.",
abstract = "Reconstruction techniques for pathological fractures caused by bone metastases often include acrylic cement to stabilise defects. The aim of this study was to test in a rodent model, whether outcome could be improved by local chemotherapy from an anticancer drug added to the acrylic cement. Tumour excision 17 days after transplantation into the femur was followed by fractionated irradiation. Supplementation of acrylic cement with daunorubicin led to a considerable reduction of TCD37% from 72.9 Gy (62.2-82.8) to 29.3 Gy (21.8-37.5) (P = 0.0007). Local chemotherapy diffusing from bone cement combined with postoperative radiotherapy was highly effective in the experimental system studied.",
author = "G Fr{\"o}schle and Zieron, {J O} and Carl, {U M} and Hans-Peter Beck-Bornholdt",
year = "1998",
language = "Deutsch",
volume = "46",
pages = "317--320",
journal = "RADIOTHER ONCOL",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Combined modality treatment of bone metastases: response of the rhabdomyosarcoma R1H of the rat to postoperative irradiation combined with local release of daunorubicin from acrylic cement.

AU - Fröschle, G

AU - Zieron, J O

AU - Carl, U M

AU - Beck-Bornholdt, Hans-Peter

PY - 1998

Y1 - 1998

N2 - Reconstruction techniques for pathological fractures caused by bone metastases often include acrylic cement to stabilise defects. The aim of this study was to test in a rodent model, whether outcome could be improved by local chemotherapy from an anticancer drug added to the acrylic cement. Tumour excision 17 days after transplantation into the femur was followed by fractionated irradiation. Supplementation of acrylic cement with daunorubicin led to a considerable reduction of TCD37% from 72.9 Gy (62.2-82.8) to 29.3 Gy (21.8-37.5) (P = 0.0007). Local chemotherapy diffusing from bone cement combined with postoperative radiotherapy was highly effective in the experimental system studied.

AB - Reconstruction techniques for pathological fractures caused by bone metastases often include acrylic cement to stabilise defects. The aim of this study was to test in a rodent model, whether outcome could be improved by local chemotherapy from an anticancer drug added to the acrylic cement. Tumour excision 17 days after transplantation into the femur was followed by fractionated irradiation. Supplementation of acrylic cement with daunorubicin led to a considerable reduction of TCD37% from 72.9 Gy (62.2-82.8) to 29.3 Gy (21.8-37.5) (P = 0.0007). Local chemotherapy diffusing from bone cement combined with postoperative radiotherapy was highly effective in the experimental system studied.

M3 - SCORING: Zeitschriftenaufsatz

VL - 46

SP - 317

EP - 320

JO - RADIOTHER ONCOL

JF - RADIOTHER ONCOL

SN - 0167-8140

IS - 3

M1 - 3

ER -