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Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure

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Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure. / Bockmann, Jan-Hendrik; Dandri-Petersen, Maura; Lüth, Stefan; Pannicke, Nadine; Lohse, Ansgar W; Dandri-Petersen, Maura.

In: WORLD J GASTROENTERO, Vol. 21, No. 7, 21.02.2015, p. 2214-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bockmann, J-H, Dandri-Petersen, M, Lüth, S, Pannicke, N, Lohse, AW & Dandri-Petersen, M 2015, 'Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure', WORLD J GASTROENTERO, vol. 21, no. 7, pp. 2214-9. https://doi.org/10.3748/wjg.v21.i7.2214

APA

Bockmann, J-H., Dandri-Petersen, M., Lüth, S., Pannicke, N., Lohse, A. W., & Dandri-Petersen, M. (2015). Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure. WORLD J GASTROENTERO, 21(7), 2214-9. https://doi.org/10.3748/wjg.v21.i7.2214

Vancouver

Bockmann J-H, Dandri-Petersen M, Lüth S, Pannicke N, Lohse AW, Dandri-Petersen M. Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure. WORLD J GASTROENTERO. 2015 Feb 21;21(7):2214-9. https://doi.org/10.3748/wjg.v21.i7.2214

Bibtex

@article{2c2f02821ae9478c8dc78aa4ef7363fe,
title = "Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure",
abstract = "Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mechanism leading to fulminant hepatitis B is thought to be primarily immune-mediated. Therefore, immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B. Here we report our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment, which resulted in a rapid improvement of clinical and liver parameters.",
author = "Jan-Hendrik Bockmann and Maura Dandri-Petersen and Stefan L{\"u}th and Nadine Pannicke and Lohse, {Ansgar W} and Maura Dandri-Petersen",
year = "2015",
month = feb,
day = "21",
doi = "10.3748/wjg.v21.i7.2214",
language = "English",
volume = "21",
pages = "2214--9",
journal = "WORLD J GASTROENTERO",
issn = "1007-9327",
publisher = "WJG Press",
number = "7",

}

RIS

TY - JOUR

T1 - Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure

AU - Bockmann, Jan-Hendrik

AU - Dandri-Petersen, Maura

AU - Lüth, Stefan

AU - Pannicke, Nadine

AU - Lohse, Ansgar W

AU - Dandri-Petersen, Maura

PY - 2015/2/21

Y1 - 2015/2/21

N2 - Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mechanism leading to fulminant hepatitis B is thought to be primarily immune-mediated. Therefore, immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B. Here we report our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment, which resulted in a rapid improvement of clinical and liver parameters.

AB - Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mechanism leading to fulminant hepatitis B is thought to be primarily immune-mediated. Therefore, immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B. Here we report our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment, which resulted in a rapid improvement of clinical and liver parameters.

U2 - 10.3748/wjg.v21.i7.2214

DO - 10.3748/wjg.v21.i7.2214

M3 - SCORING: Journal article

C2 - 25717260

VL - 21

SP - 2214

EP - 2219

JO - WORLD J GASTROENTERO

JF - WORLD J GASTROENTERO

SN - 1007-9327

IS - 7

ER -