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Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions

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Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions. / Elmas, Hatice; Biancosino, Christian; Önal, Binnur; Schmitt, Fernando; Buyucek, Seyma; Nordholt, Gerhard; Sauter, Guido; Welker, Lutz.

In: ADV EXP MED BIOL, Vol. 1374, 2022, p. 51-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Elmas, H, Biancosino, C, Önal, B, Schmitt, F, Buyucek, S, Nordholt, G, Sauter, G & Welker, L 2022, 'Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions', ADV EXP MED BIOL, vol. 1374, pp. 51-62. https://doi.org/10.1007/5584_2021_703

APA

Elmas, H., Biancosino, C., Önal, B., Schmitt, F., Buyucek, S., Nordholt, G., Sauter, G., & Welker, L. (2022). Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions. ADV EXP MED BIOL, 1374, 51-62. https://doi.org/10.1007/5584_2021_703

Vancouver

Elmas H, Biancosino C, Önal B, Schmitt F, Buyucek S, Nordholt G et al. Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions. ADV EXP MED BIOL. 2022;1374:51-62. https://doi.org/10.1007/5584_2021_703

Bibtex

@article{f8879a407a8b460fab1c3f4ee282f52f,
title = "Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions",
abstract = "Serous pleural effusions result from increased permeability and changed hydrostatic or colloid osmotic pressure. Laboratory biochemical findings provide conclusions about the effusion compositions. Together with the anamnesis and clinical assessment, they enable the evaluation of the effusion nature. The present study retrospectively analyzed combined biochemical and morphological findings in 2307 effusions of patients from two clinical centers: LungenClinic Grosshansdorf in Germany and Duzce University in Turkey. The effusion cytology results of 1771 and 536 patients from the respective centers were combined with clinical/radiological/biochemical findings and counter compared with the final diagnoses. Cytology verified 738 malignant tumors (643 and 95, respectively). Most effusions were benign (n = 1569; 77%) and 367 of them were paramalignant (293 and 74, respectively) and 594 were inflammatory (465 and 129, respectively). There was a distinctly lower number of malignant tumors in transudates than exudates (87 vs. 725; p < 0.0001). Squamous cell carcinoma was more frequent in paramalignant pleura effusions (122 cases out of the 367 effusions) than pleural carcinomatosis (32 cases out of the 780 malignant tumors; p < 0.0001). The cell formula was a suitable marker for malignant mesothelioma, predominantly mesothelial, or neutrophilic characterized by elevated LDH (>500 U/L) in the early stage of empyema or its late manifestation. İn conclusion, most effusions are benign. Cytologists, assisted by clinical and biochemical data and microscopic findings, can make significant differential diagnostic contributions beyond the sole detection of malignancy.",
keywords = "Carcinoma, Squamous Cell/diagnosis, Diagnosis, Differential, Humans, Pleural Effusion/diagnosis, Pleural Effusion, Malignant/diagnosis, Pleural Neoplasms/diagnosis, Retrospective Studies",
author = "Hatice Elmas and Christian Biancosino and Binnur {\"O}nal and Fernando Schmitt and Seyma Buyucek and Gerhard Nordholt and Guido Sauter and Lutz Welker",
note = "{\textcopyright} 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/5584_2021_703",
language = "English",
volume = "1374",
pages = "51--62",
journal = "ADV EXP MED BIOL",
issn = "0065-2598",
publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions

AU - Elmas, Hatice

AU - Biancosino, Christian

AU - Önal, Binnur

AU - Schmitt, Fernando

AU - Buyucek, Seyma

AU - Nordholt, Gerhard

AU - Sauter, Guido

AU - Welker, Lutz

N1 - © 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.

PY - 2022

Y1 - 2022

N2 - Serous pleural effusions result from increased permeability and changed hydrostatic or colloid osmotic pressure. Laboratory biochemical findings provide conclusions about the effusion compositions. Together with the anamnesis and clinical assessment, they enable the evaluation of the effusion nature. The present study retrospectively analyzed combined biochemical and morphological findings in 2307 effusions of patients from two clinical centers: LungenClinic Grosshansdorf in Germany and Duzce University in Turkey. The effusion cytology results of 1771 and 536 patients from the respective centers were combined with clinical/radiological/biochemical findings and counter compared with the final diagnoses. Cytology verified 738 malignant tumors (643 and 95, respectively). Most effusions were benign (n = 1569; 77%) and 367 of them were paramalignant (293 and 74, respectively) and 594 were inflammatory (465 and 129, respectively). There was a distinctly lower number of malignant tumors in transudates than exudates (87 vs. 725; p < 0.0001). Squamous cell carcinoma was more frequent in paramalignant pleura effusions (122 cases out of the 367 effusions) than pleural carcinomatosis (32 cases out of the 780 malignant tumors; p < 0.0001). The cell formula was a suitable marker for malignant mesothelioma, predominantly mesothelial, or neutrophilic characterized by elevated LDH (>500 U/L) in the early stage of empyema or its late manifestation. İn conclusion, most effusions are benign. Cytologists, assisted by clinical and biochemical data and microscopic findings, can make significant differential diagnostic contributions beyond the sole detection of malignancy.

AB - Serous pleural effusions result from increased permeability and changed hydrostatic or colloid osmotic pressure. Laboratory biochemical findings provide conclusions about the effusion compositions. Together with the anamnesis and clinical assessment, they enable the evaluation of the effusion nature. The present study retrospectively analyzed combined biochemical and morphological findings in 2307 effusions of patients from two clinical centers: LungenClinic Grosshansdorf in Germany and Duzce University in Turkey. The effusion cytology results of 1771 and 536 patients from the respective centers were combined with clinical/radiological/biochemical findings and counter compared with the final diagnoses. Cytology verified 738 malignant tumors (643 and 95, respectively). Most effusions were benign (n = 1569; 77%) and 367 of them were paramalignant (293 and 74, respectively) and 594 were inflammatory (465 and 129, respectively). There was a distinctly lower number of malignant tumors in transudates than exudates (87 vs. 725; p < 0.0001). Squamous cell carcinoma was more frequent in paramalignant pleura effusions (122 cases out of the 367 effusions) than pleural carcinomatosis (32 cases out of the 780 malignant tumors; p < 0.0001). The cell formula was a suitable marker for malignant mesothelioma, predominantly mesothelial, or neutrophilic characterized by elevated LDH (>500 U/L) in the early stage of empyema or its late manifestation. İn conclusion, most effusions are benign. Cytologists, assisted by clinical and biochemical data and microscopic findings, can make significant differential diagnostic contributions beyond the sole detection of malignancy.

KW - Carcinoma, Squamous Cell/diagnosis

KW - Diagnosis, Differential

KW - Humans

KW - Pleural Effusion/diagnosis

KW - Pleural Effusion, Malignant/diagnosis

KW - Pleural Neoplasms/diagnosis

KW - Retrospective Studies

U2 - 10.1007/5584_2021_703

DO - 10.1007/5584_2021_703

M3 - SCORING: Journal article

C2 - 35147931

VL - 1374

SP - 51

EP - 62

JO - ADV EXP MED BIOL

JF - ADV EXP MED BIOL

SN - 0065-2598

ER -