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Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease

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Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease. / Lindquist, Jonathan A; Bernhardt, Anja; Reichardt, Charlotte; Sauter, Eva; Brandt, Sabine; Rana, Rajiv; Lindenmeyer, Maja T; Philipsen, Lars; Isermann, Berend; Zhu, Cheng; Mertens, Peter R.

In: CELLS-BASEL, Vol. 12, No. 10, 1426, 19.05.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lindquist, JA, Bernhardt, A, Reichardt, C, Sauter, E, Brandt, S, Rana, R, Lindenmeyer, MT, Philipsen, L, Isermann, B, Zhu, C & Mertens, PR 2023, 'Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease', CELLS-BASEL, vol. 12, no. 10, 1426. https://doi.org/10.3390/cells12101426

APA

Lindquist, J. A., Bernhardt, A., Reichardt, C., Sauter, E., Brandt, S., Rana, R., Lindenmeyer, M. T., Philipsen, L., Isermann, B., Zhu, C., & Mertens, P. R. (2023). Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease. CELLS-BASEL, 12(10), [1426]. https://doi.org/10.3390/cells12101426

Vancouver

Lindquist JA, Bernhardt A, Reichardt C, Sauter E, Brandt S, Rana R et al. Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease. CELLS-BASEL. 2023 May 19;12(10). 1426. https://doi.org/10.3390/cells12101426

Bibtex

@article{026bc6791c7f4c508323b4f9ee6d7914,
title = "Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease",
abstract = "DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain proteins that exert transcriptional and translational activities in the cell via their ability to bind and regulate mRNA. To investigate the role of DbpA in kidney disease, we utilized the murine unilateral ureter obstruction (UUO) model, which recapitulates many features of obstructive nephropathy seen in humans. We observed that DbpA protein expression is induced within the renal interstitium following disease induction. Compared with wild-type animals, obstructed kidneys from Ybx3-deficient mice are protected from tissue injury, with a significant reduction in the number of infiltrating immune cells as well as in extracellular matrix deposition. RNAseq data from UUO kidneys show that Ybx3 is expressed by activated fibroblasts, which reside within the renal interstitium. Our data support a role for DbpA in orchestrating renal fibrosis and suggest that strategies targeting DbpA may be a therapeutic option to slow disease progression.",
keywords = "Animals, Mice, Cold-Shock Response, DNA-Binding Proteins/metabolism, Fibrosis, Kidney Diseases/pathology, Kidney Tubules/pathology, Ureteral Obstruction/complications",
author = "Lindquist, {Jonathan A} and Anja Bernhardt and Charlotte Reichardt and Eva Sauter and Sabine Brandt and Rajiv Rana and Lindenmeyer, {Maja T} and Lars Philipsen and Berend Isermann and Cheng Zhu and Mertens, {Peter R}",
year = "2023",
month = may,
day = "19",
doi = "10.3390/cells12101426",
language = "English",
volume = "12",
journal = "CELLS-BASEL",
issn = "2073-4409",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "10",

}

RIS

TY - JOUR

T1 - Cold Shock Domain Protein DbpA Orchestrates Tubular Cell Damage and Interstitial Fibrosis in Inflammatory Kidney Disease

AU - Lindquist, Jonathan A

AU - Bernhardt, Anja

AU - Reichardt, Charlotte

AU - Sauter, Eva

AU - Brandt, Sabine

AU - Rana, Rajiv

AU - Lindenmeyer, Maja T

AU - Philipsen, Lars

AU - Isermann, Berend

AU - Zhu, Cheng

AU - Mertens, Peter R

PY - 2023/5/19

Y1 - 2023/5/19

N2 - DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain proteins that exert transcriptional and translational activities in the cell via their ability to bind and regulate mRNA. To investigate the role of DbpA in kidney disease, we utilized the murine unilateral ureter obstruction (UUO) model, which recapitulates many features of obstructive nephropathy seen in humans. We observed that DbpA protein expression is induced within the renal interstitium following disease induction. Compared with wild-type animals, obstructed kidneys from Ybx3-deficient mice are protected from tissue injury, with a significant reduction in the number of infiltrating immune cells as well as in extracellular matrix deposition. RNAseq data from UUO kidneys show that Ybx3 is expressed by activated fibroblasts, which reside within the renal interstitium. Our data support a role for DbpA in orchestrating renal fibrosis and suggest that strategies targeting DbpA may be a therapeutic option to slow disease progression.

AB - DNA-binding protein A (DbpA) belongs to the Y-box family of cold shock domain proteins that exert transcriptional and translational activities in the cell via their ability to bind and regulate mRNA. To investigate the role of DbpA in kidney disease, we utilized the murine unilateral ureter obstruction (UUO) model, which recapitulates many features of obstructive nephropathy seen in humans. We observed that DbpA protein expression is induced within the renal interstitium following disease induction. Compared with wild-type animals, obstructed kidneys from Ybx3-deficient mice are protected from tissue injury, with a significant reduction in the number of infiltrating immune cells as well as in extracellular matrix deposition. RNAseq data from UUO kidneys show that Ybx3 is expressed by activated fibroblasts, which reside within the renal interstitium. Our data support a role for DbpA in orchestrating renal fibrosis and suggest that strategies targeting DbpA may be a therapeutic option to slow disease progression.

KW - Animals

KW - Mice

KW - Cold-Shock Response

KW - DNA-Binding Proteins/metabolism

KW - Fibrosis

KW - Kidney Diseases/pathology

KW - Kidney Tubules/pathology

KW - Ureteral Obstruction/complications

U2 - 10.3390/cells12101426

DO - 10.3390/cells12101426

M3 - SCORING: Journal article

C2 - 37408260

VL - 12

JO - CELLS-BASEL

JF - CELLS-BASEL

SN - 2073-4409

IS - 10

M1 - 1426

ER -