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Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.

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Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing. / Gallistel, R.C.; Tucci, Valter; Nolan, Patrick N.; Schachner, Melitta; Jakovcevski, Igor; Kheifets, Aaron; Barboza, Luendro .

In: PHILOS T R SOC B, Vol. 369, No. 1637, 2014, p. 20120464.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gallistel, RC, Tucci, V, Nolan, PN, Schachner, M, Jakovcevski, I, Kheifets, A & Barboza, L 2014, 'Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.', PHILOS T R SOC B, vol. 369, no. 1637, pp. 20120464. https://doi.org/doi: 10.1098/rstb.2012.0464

APA

Gallistel, R. C., Tucci, V., Nolan, P. N., Schachner, M., Jakovcevski, I., Kheifets, A., & Barboza, L. (2014). Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing. PHILOS T R SOC B, 369(1637), 20120464. https://doi.org/doi: 10.1098/rstb.2012.0464

Vancouver

Gallistel RC, Tucci V, Nolan PN, Schachner M, Jakovcevski I, Kheifets A et al. Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing. PHILOS T R SOC B. 2014;369(1637):20120464. https://doi.org/doi: 10.1098/rstb.2012.0464

Bibtex

@article{b716babca6b84d9a826661fad072a651,
title = "Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.",
abstract = "We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.",
author = "R.C. Gallistel and Valter Tucci and Nolan, {Patrick N.} and Melitta Schachner and Igor Jakovcevski and Aaron Kheifets and Luendro Barboza",
year = "2014",
doi = "doi: 10.1098/rstb.2012.0464",
language = "English",
volume = "369",
pages = "20120464",
journal = "PHILOS T R SOC B",
issn = "0962-8436",
publisher = "Royal Society of London",
number = "1637",

}

RIS

TY - JOUR

T1 - Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.

AU - Gallistel, R.C.

AU - Tucci, Valter

AU - Nolan, Patrick N.

AU - Schachner, Melitta

AU - Jakovcevski, Igor

AU - Kheifets, Aaron

AU - Barboza, Luendro

PY - 2014

Y1 - 2014

N2 - We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.

AB - We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. Both of the target genes are involved in the establishment and maintenance of synapses. We find that the Bfc heterozygotes show reduced precision in their representation of interval duration, whereas the L1 heterozygotes show increased precision. These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability.

U2 - doi: 10.1098/rstb.2012.0464

DO - doi: 10.1098/rstb.2012.0464

M3 - SCORING: Journal article

VL - 369

SP - 20120464

JO - PHILOS T R SOC B

JF - PHILOS T R SOC B

SN - 0962-8436

IS - 1637

ER -