Coexistence and outcome of coronary artery disease in Takotsubo syndrome

L Christian Napp; Victoria L Cammann; Milosz Jaguszewski; Konrad A Szawan; Manfred Wischnewsky; Sebastiano Gili; Maike Knorr; Susanne Heiner; Rodolfo Citro; Eduardo Bossone; Fabrizio D'Ascenzo; Michael Neuhaus; Jennifer Franke; Ioana Sorici-Barb; Michel Noutsias; Christof Burgdorf; Wolfgang Koenig; Behrouz Kherad; Annahita Sarcon; Lawrence Rajan; Guido Michels; Roman Pfister; Alessandro Cuneo; Claudius Jacobshagen; Mahir Karakas; Alexander Pott; Philippe Meyer; Jose D Arroja; Adrian Banning; Florim Cuculi; Richard Kobza; Thomas A Fischer; Tuija Vasankari; K E Juhani Airaksinen; Christian Hauck; Carla Paolini; Claudio Bilato; Yoichi Imori; Ken Kato; Yoshio Kobayashi; Grzegorz Opolski; Monika Budnik; Rafal Dworakowski; Philip MacCarthy; Christoph Kaiser; Stefan Osswald; Leonarda Galiuto; Wolfgang Dichtl; Christina Chan; Paul Bridgman; Daniel Beug; Clément Delmas; Olivier Lairez; Ibrahim El-Battrawy; Ibrahim Akin; Ekaterina Gilyarova; Alexandra Shilova; Mikhail Gilyarov; John D Horowitz; Karolina Polednikova; Petr Tousek; Petr Widimský; David E Winchester; Jan Galuszka; Christian Ukena; Gregor Poglajen; Pedro Carrilho-Ferreira; Carlo Di Mario; Abhiram Prasad; Charanjit S Rihal; P Christian Schulze; Matteo Bianco; Filippo Crea; Martin Borggrefe; Lars S Maier; Fausto J Pinto; Ruediger C Braun-Dullaeus; Wolfgang Rottbauer; Hugo A Katus; Gerd Hasenfuß; Carsten Tschöpe; Burkert M Pieske; Holger Thiele; Heribert Schunkert; Michael Böhm; Stephan B Felix; Thomas Münzel; Jeroen J Bax; Johann Bauersachs; Eugene Braunwald; Thomas F Lüscher; Frank Ruschitzka; Jelena R Ghadri; Christian Templin

doi:10.1093/eurheartj/ehaa210

Coexistence and outcome of coronary artery disease in Takotsubo syndrome

Standard

Coexistence and outcome of coronary artery disease in Takotsubo syndrome. / Napp, L Christian; Cammann, Victoria L; Jaguszewski, Milosz; Szawan, Konrad A; Wischnewsky, Manfred; Gili, Sebastiano; Knorr, Maike; Heiner, Susanne; Citro, Rodolfo; Bossone, Eduardo; D'Ascenzo, Fabrizio; Neuhaus, Michael; Franke, Jennifer; Sorici-Barb, Ioana; Noutsias, Michel; Burgdorf, Christof; Koenig, Wolfgang; Kherad, Behrouz; Sarcon, Annahita; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Karakas, Mahir; Pott, Alexander; Meyer, Philippe; Arroja, Jose D; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Hauck, Christian; Paolini, Carla; Bilato, Claudio; Imori, Yoichi; Kato, Ken; Kobayashi, Yoshio; Opolski, Grzegorz; Budnik, Monika; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Dichtl, Wolfgang; Chan, Christina; Bridgman, Paul; Beug, Daniel; Delmas, Clément; Lairez, Olivier; El-Battrawy, Ibrahim; Akin, Ibrahim; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Horowitz, John D; Polednikova, Karolina; Tousek, Petr; Widimský, Petr; Winchester, David E; Galuszka, Jan; Ukena, Christian; Poglajen, Gregor; Carrilho-Ferreira, Pedro; Di Mario, Carlo; Prasad, Abhiram; Rihal, Charanjit S; Schulze, P Christian; Bianco, Matteo; Crea, Filippo; Borggrefe, Martin; Maier, Lars S; Pinto, Fausto J; Braun-Dullaeus, Ruediger C; Rottbauer, Wolfgang; Katus, Hugo A; Hasenfuß, Gerd; Tschöpe, Carsten; Pieske, Burkert M; Thiele, Holger; Schunkert, Heribert; Böhm, Michael; Felix, Stephan B; Münzel, Thomas; Bax, Jeroen J; Bauersachs, Johann; Braunwald, Eugene; Lüscher, Thomas F; Ruschitzka, Frank; Ghadri, Jelena R; Templin, Christian.

In: EUR HEART J, Vol. 41, No. 34, 07.09.2020, p. 3255-3268.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Napp, LC, Cammann, VL, Jaguszewski, M, Szawan, KA, Wischnewsky, M, Gili, S, Knorr, M, Heiner, S, Citro, R, Bossone, E, D'Ascenzo, F, Neuhaus, M, Franke, J, Sorici-Barb, I, Noutsias, M, Burgdorf, C, Koenig, W, Kherad, B, Sarcon, A, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Pott, A, Meyer, P, Arroja, JD, Banning, A, Cuculi, F, Kobza, R, Fischer, TA, Vasankari, T, Airaksinen, KEJ, Hauck, C, Paolini, C, Bilato, C, Imori, Y, Kato, K, Kobayashi, Y, Opolski, G, Budnik, M, Dworakowski, R, MacCarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Beug, D, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Gilyarova, E, Shilova, A, Gilyarov, M, Horowitz, JD, Polednikova, K, Tousek, P, Widimský, P, Winchester, DE, Galuszka, J, Ukena, C, Poglajen, G, Carrilho-Ferreira, P, Di Mario, C, Prasad, A, Rihal, CS, Schulze, PC, Bianco, M, Crea, F, Borggrefe, M, Maier, LS, Pinto, FJ, Braun-Dullaeus, RC, Rottbauer, W, Katus, HA, Hasenfuß, G, Tschöpe, C, Pieske, BM, Thiele, H, Schunkert, H, Böhm, M, Felix, SB, Münzel, T, Bax, JJ, Bauersachs, J, Braunwald, E, Lüscher, TF, Ruschitzka, F, Ghadri, JR & Templin, C 2020, 'Coexistence and outcome of coronary artery disease in Takotsubo syndrome', EUR HEART J, vol. 41, no. 34, pp. 3255-3268. https://doi.org/10.1093/eurheartj/ehaa210

APA

Napp, L. C., Cammann, V. L., Jaguszewski, M., Szawan, K. A., Wischnewsky, M., Gili, S., Knorr, M., Heiner, S., Citro, R., Bossone, E., D'Ascenzo, F., Neuhaus, M., Franke, J., Sorici-Barb, I., Noutsias, M., Burgdorf, C., Koenig, W., Kherad, B., Sarcon, A., ... Templin, C. (2020). Coexistence and outcome of coronary artery disease in Takotsubo syndrome. EUR HEART J, 41(34), 3255-3268. https://doi.org/10.1093/eurheartj/ehaa210

Vancouver

Napp LC, Cammann VL, Jaguszewski M, Szawan KA, Wischnewsky M, Gili S et al. Coexistence and outcome of coronary artery disease in Takotsubo syndrome. EUR HEART J. 2020 Sep 7;41(34):3255-3268. https://doi.org/10.1093/eurheartj/ehaa210

Bibtex

@article{a321977fce5949f5a0a061db5740682b,

title = "Coexistence and outcome of coronary artery disease in Takotsubo syndrome",

abstract = "AIMS: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS.METHODS AND RESULTS: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort.CONCLUSIONS: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.TRIAL REGISTRATION: ClinicalTrials.gov number: NCT01947621.",

keywords = "Acute Coronary Syndrome, Coronary Angiography, Coronary Artery Disease/complications, Humans, Incidence, Takotsubo Cardiomyopathy/complications",

author = "Napp, {L Christian} and Cammann, {Victoria L} and Milosz Jaguszewski and Szawan, {Konrad A} and Manfred Wischnewsky and Sebastiano Gili and Maike Knorr and Susanne Heiner and Rodolfo Citro and Eduardo Bossone and Fabrizio D'Ascenzo and Michael Neuhaus and Jennifer Franke and Ioana Sorici-Barb and Michel Noutsias and Christof Burgdorf and Wolfgang Koenig and Behrouz Kherad and Annahita Sarcon and Lawrence Rajan and Guido Michels and Roman Pfister and Alessandro Cuneo and Claudius Jacobshagen and Mahir Karakas and Alexander Pott and Philippe Meyer and Arroja, {Jose D} and Adrian Banning and Florim Cuculi and Richard Kobza and Fischer, {Thomas A} and Tuija Vasankari and Airaksinen, {K E Juhani} and Christian Hauck and Carla Paolini and Claudio Bilato and Yoichi Imori and Ken Kato and Yoshio Kobayashi and Grzegorz Opolski and Monika Budnik and Rafal Dworakowski and Philip MacCarthy and Christoph Kaiser and Stefan Osswald and Leonarda Galiuto and Wolfgang Dichtl and Christina Chan and Paul Bridgman and Daniel Beug and Cl{\'e}ment Delmas and Olivier Lairez and Ibrahim El-Battrawy and Ibrahim Akin and Ekaterina Gilyarova and Alexandra Shilova and Mikhail Gilyarov and Horowitz, {John D} and Karolina Polednikova and Petr Tousek and Petr Widimsk{\'y} and Winchester, {David E} and Jan Galuszka and Christian Ukena and Gregor Poglajen and Pedro Carrilho-Ferreira and {Di Mario}, Carlo and Abhiram Prasad and Rihal, {Charanjit S} and Schulze, {P Christian} and Matteo Bianco and Filippo Crea and Martin Borggrefe and Maier, {Lars S} and Pinto, {Fausto J} and Braun-Dullaeus, {Ruediger C} and Wolfgang Rottbauer and Katus, {Hugo A} and Gerd Hasenfu{\ss} and Carsten Tsch{\"o}pe and Pieske, {Burkert M} and Holger Thiele and Heribert Schunkert and Michael B{\"o}hm and Felix, {Stephan B} and Thomas M{\"u}nzel and Bax, {Jeroen J} and Johann Bauersachs and Eugene Braunwald and L{\"u}scher, {Thomas F} and Frank Ruschitzka and Ghadri, {Jelena R} and Christian Templin",

year = "2020",

month = sep,

day = "7",

doi = "10.1093/eurheartj/ehaa210",

language = "English",

volume = "41",

pages = "3255--3268",

journal = "EUR HEART J",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "34",

}

RIS

TY - JOUR

T1 - Coexistence and outcome of coronary artery disease in Takotsubo syndrome

AU - Napp, L Christian

AU - Cammann, Victoria L

AU - Jaguszewski, Milosz

AU - Szawan, Konrad A

AU - Wischnewsky, Manfred

AU - Gili, Sebastiano

AU - Knorr, Maike

AU - Heiner, Susanne

AU - Citro, Rodolfo

AU - Bossone, Eduardo

AU - D'Ascenzo, Fabrizio

AU - Neuhaus, Michael

AU - Franke, Jennifer

AU - Sorici-Barb, Ioana

AU - Noutsias, Michel

AU - Burgdorf, Christof

AU - Koenig, Wolfgang

AU - Kherad, Behrouz

AU - Sarcon, Annahita

AU - Rajan, Lawrence

AU - Michels, Guido

AU - Pfister, Roman

AU - Cuneo, Alessandro

AU - Jacobshagen, Claudius

AU - Karakas, Mahir

AU - Pott, Alexander

AU - Meyer, Philippe

AU - Arroja, Jose D

AU - Banning, Adrian

AU - Cuculi, Florim

AU - Kobza, Richard

AU - Fischer, Thomas A

AU - Vasankari, Tuija

AU - Airaksinen, K E Juhani

AU - Hauck, Christian

AU - Paolini, Carla

AU - Bilato, Claudio

AU - Imori, Yoichi

AU - Kato, Ken

AU - Kobayashi, Yoshio

AU - Opolski, Grzegorz

AU - Budnik, Monika

AU - Dworakowski, Rafal

AU - MacCarthy, Philip

AU - Kaiser, Christoph

AU - Osswald, Stefan

AU - Galiuto, Leonarda

AU - Dichtl, Wolfgang

AU - Chan, Christina

AU - Bridgman, Paul

AU - Beug, Daniel

AU - Delmas, Clément

AU - Lairez, Olivier

AU - El-Battrawy, Ibrahim

AU - Akin, Ibrahim

AU - Gilyarova, Ekaterina

AU - Shilova, Alexandra

AU - Gilyarov, Mikhail

AU - Horowitz, John D

AU - Polednikova, Karolina

AU - Tousek, Petr

AU - Widimský, Petr

AU - Winchester, David E

AU - Galuszka, Jan

AU - Ukena, Christian

AU - Poglajen, Gregor

AU - Carrilho-Ferreira, Pedro

AU - Di Mario, Carlo

AU - Prasad, Abhiram

AU - Rihal, Charanjit S

AU - Schulze, P Christian

AU - Bianco, Matteo

AU - Crea, Filippo

AU - Borggrefe, Martin

AU - Maier, Lars S

AU - Pinto, Fausto J

AU - Braun-Dullaeus, Ruediger C

AU - Rottbauer, Wolfgang

AU - Katus, Hugo A

AU - Hasenfuß, Gerd

AU - Tschöpe, Carsten

AU - Pieske, Burkert M

AU - Thiele, Holger

AU - Schunkert, Heribert

AU - Böhm, Michael

AU - Felix, Stephan B

AU - Münzel, Thomas

AU - Bax, Jeroen J

AU - Bauersachs, Johann

AU - Braunwald, Eugene

AU - Lüscher, Thomas F

AU - Ruschitzka, Frank

AU - Ghadri, Jelena R

AU - Templin, Christian

PY - 2020/9/7

Y1 - 2020/9/7

N2 - AIMS: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS.METHODS AND RESULTS: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort.CONCLUSIONS: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.TRIAL REGISTRATION: ClinicalTrials.gov number: NCT01947621.

AB - AIMS: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS.METHODS AND RESULTS: Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort.CONCLUSIONS: Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome.TRIAL REGISTRATION: ClinicalTrials.gov number: NCT01947621.

KW - Acute Coronary Syndrome

KW - Coronary Angiography

KW - Coronary Artery Disease/complications

KW - Humans

KW - Incidence

KW - Takotsubo Cardiomyopathy/complications

U2 - 10.1093/eurheartj/ehaa210

DO - 10.1093/eurheartj/ehaa210

M3 - SCORING: Journal article

C2 - 32484517

VL - 41

SP - 3255

EP - 3268

JO - EUR HEART J

JF - EUR HEART J

SN - 0195-668X

IS - 34

ER -