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CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study

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CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. / Clemm von Hohenberg, Christian; Wiegand, Marlene C; Kubicki, Marek; Leicht, Gregor; Giegling, Ina; Karch, Susanne; Hartmann, Annette M; Konte, Bettina; Friedl, Marion; Ballinger, Thomas; Eckbo, Ryan; Bouix, Sylvain; Jäger, Lorenz; Shenton, Martha E; Rujescu, Dan; Mulert, Christoph.

In: J PSYCHIATR RES, Vol. 47, No. 10, 01.10.2013, p. 1349-56.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Clemm von Hohenberg, C, Wiegand, MC, Kubicki, M, Leicht, G, Giegling, I, Karch, S, Hartmann, AM, Konte, B, Friedl, M, Ballinger, T, Eckbo, R, Bouix, S, Jäger, L, Shenton, ME, Rujescu, D & Mulert, C 2013, 'CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study', J PSYCHIATR RES, vol. 47, no. 10, pp. 1349-56. https://doi.org/10.1016/j.jpsychires.2013.07.002

APA

Clemm von Hohenberg, C., Wiegand, M. C., Kubicki, M., Leicht, G., Giegling, I., Karch, S., Hartmann, A. M., Konte, B., Friedl, M., Ballinger, T., Eckbo, R., Bouix, S., Jäger, L., Shenton, M. E., Rujescu, D., & Mulert, C. (2013). CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. J PSYCHIATR RES, 47(10), 1349-56. https://doi.org/10.1016/j.jpsychires.2013.07.002

Vancouver

Clemm von Hohenberg C, Wiegand MC, Kubicki M, Leicht G, Giegling I, Karch S et al. CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. J PSYCHIATR RES. 2013 Oct 1;47(10):1349-56. https://doi.org/10.1016/j.jpsychires.2013.07.002

Bibtex

@article{9fc652f99c9e4ce49387c5a7a85dd55a,
title = "CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study",
abstract = "CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical brain connectivity, and multiple single nucleotide polymorphisms (SNPs) spread out over this large gene. 81 healthy controls and 44 patients with schizophrenia (all Caucasian) underwent DTI and genotyping of 31 SNPs within CNTNAP2. We employed Tract-based Spatial Statistics (TBSS) for inter-subject brain registration and computed average diffusivity values for six major white matter tracts. Analyses of Covariance (ANCOVAs) were computed to test for possible associations with genotypes. The strongest association, which survived rigorous Bonferroni correction, was between rs2710126 genotype and Fractional Anisotropy (FA) in the uncinate fasciculus (p = .00003). This anatomical location is particularly interesting given the enriched fronto-temporal expression of CNTNAP2 in the developing brain. For this SNP, no phenotype association has been reported before. There were several further genotype-DTI associations that were nominally significant but did not survive Bonferroni correction, including an association between axial diffusivity in the dorsal cingulum bundle and a region in intron 13 (represented by rs2710102, rs759178, rs2538991), which has previously been reported to be associated with anterior-posterior functional connectivity. We present new evidence about the effects of CNTNAP2 on brain connectivity, whose disruption has been hypothesized to be central to schizophrenia pathophysiology.",
keywords = "Adult, Anisotropy, Brain, DNA Mutational Analysis, Diffusion Tensor Imaging, Female, Genotype, Humans, Male, Membrane Proteins, Middle Aged, Nerve Fibers, Myelinated, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Psychiatric Status Rating Scales, Schizophrenia, Statistics, Nonparametric",
author = "{Clemm von Hohenberg}, Christian and Wiegand, {Marlene C} and Marek Kubicki and Gregor Leicht and Ina Giegling and Susanne Karch and Hartmann, {Annette M} and Bettina Konte and Marion Friedl and Thomas Ballinger and Ryan Eckbo and Sylvain Bouix and Lorenz J{\"a}ger and Shenton, {Martha E} and Dan Rujescu and Christoph Mulert",
note = "{\textcopyright} 2013 Published by Elsevier Ltd.",
year = "2013",
month = oct,
day = "1",
doi = "10.1016/j.jpsychires.2013.07.002",
language = "English",
volume = "47",
pages = "1349--56",
journal = "J PSYCHIATR RES",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study

AU - Clemm von Hohenberg, Christian

AU - Wiegand, Marlene C

AU - Kubicki, Marek

AU - Leicht, Gregor

AU - Giegling, Ina

AU - Karch, Susanne

AU - Hartmann, Annette M

AU - Konte, Bettina

AU - Friedl, Marion

AU - Ballinger, Thomas

AU - Eckbo, Ryan

AU - Bouix, Sylvain

AU - Jäger, Lorenz

AU - Shenton, Martha E

AU - Rujescu, Dan

AU - Mulert, Christoph

N1 - © 2013 Published by Elsevier Ltd.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical brain connectivity, and multiple single nucleotide polymorphisms (SNPs) spread out over this large gene. 81 healthy controls and 44 patients with schizophrenia (all Caucasian) underwent DTI and genotyping of 31 SNPs within CNTNAP2. We employed Tract-based Spatial Statistics (TBSS) for inter-subject brain registration and computed average diffusivity values for six major white matter tracts. Analyses of Covariance (ANCOVAs) were computed to test for possible associations with genotypes. The strongest association, which survived rigorous Bonferroni correction, was between rs2710126 genotype and Fractional Anisotropy (FA) in the uncinate fasciculus (p = .00003). This anatomical location is particularly interesting given the enriched fronto-temporal expression of CNTNAP2 in the developing brain. For this SNP, no phenotype association has been reported before. There were several further genotype-DTI associations that were nominally significant but did not survive Bonferroni correction, including an association between axial diffusivity in the dorsal cingulum bundle and a region in intron 13 (represented by rs2710102, rs759178, rs2538991), which has previously been reported to be associated with anterior-posterior functional connectivity. We present new evidence about the effects of CNTNAP2 on brain connectivity, whose disruption has been hypothesized to be central to schizophrenia pathophysiology.

AB - CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical brain connectivity, and multiple single nucleotide polymorphisms (SNPs) spread out over this large gene. 81 healthy controls and 44 patients with schizophrenia (all Caucasian) underwent DTI and genotyping of 31 SNPs within CNTNAP2. We employed Tract-based Spatial Statistics (TBSS) for inter-subject brain registration and computed average diffusivity values for six major white matter tracts. Analyses of Covariance (ANCOVAs) were computed to test for possible associations with genotypes. The strongest association, which survived rigorous Bonferroni correction, was between rs2710126 genotype and Fractional Anisotropy (FA) in the uncinate fasciculus (p = .00003). This anatomical location is particularly interesting given the enriched fronto-temporal expression of CNTNAP2 in the developing brain. For this SNP, no phenotype association has been reported before. There were several further genotype-DTI associations that were nominally significant but did not survive Bonferroni correction, including an association between axial diffusivity in the dorsal cingulum bundle and a region in intron 13 (represented by rs2710102, rs759178, rs2538991), which has previously been reported to be associated with anterior-posterior functional connectivity. We present new evidence about the effects of CNTNAP2 on brain connectivity, whose disruption has been hypothesized to be central to schizophrenia pathophysiology.

KW - Adult

KW - Anisotropy

KW - Brain

KW - DNA Mutational Analysis

KW - Diffusion Tensor Imaging

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Membrane Proteins

KW - Middle Aged

KW - Nerve Fibers, Myelinated

KW - Nerve Tissue Proteins

KW - Polymorphism, Single Nucleotide

KW - Psychiatric Status Rating Scales

KW - Schizophrenia

KW - Statistics, Nonparametric

U2 - 10.1016/j.jpsychires.2013.07.002

DO - 10.1016/j.jpsychires.2013.07.002

M3 - SCORING: Journal article

C2 - 23871450

VL - 47

SP - 1349

EP - 1356

JO - J PSYCHIATR RES

JF - J PSYCHIATR RES

SN - 0022-3956

IS - 10

ER -