CMV in kidney transplantation: a single center experience over 22 years.
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CMV in kidney transplantation: a single center experience over 22 years. / Nashan, Björn; Lück, R; Kliem, V; Brunkhorst, R; Schlitt, H J; Klempnauer, J.
In: CLIN TRANSPLANT, 1999, p. 181-188.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - CMV in kidney transplantation: a single center experience over 22 years.
AU - Nashan, Björn
AU - Lück, R
AU - Kliem, V
AU - Brunkhorst, R
AU - Schlitt, H J
AU - Klempnauer, J
PY - 1999
Y1 - 1999
N2 - Analysis of a historic renal transplant population for risks of developing CMV disease demonstrated a low mortality (0.2%) and morbidity. In our population of 1,959 patients, 411 (21%) developed subclinical CMV infection and 220 (11%) had CMV disease which was severe in 41 (2%). Important factors for infection were baseline immunosuppression, indicating that triple therapy with the proliferation inhibitors, azathioprine and MMF, had significantly higher infection numbers in comparison to dual, CsA-based immunosuppression. The cumulative dose of steroids correlated strongly with an increased number of CMV infections and disease, as did the addition of ALG/ATG or OKT3 for either steroid-resistant rejections or induction therapy. While CMV serology had an impact on infection in cases of seropositive donors to seronegative recipients, seropositive patients, in general, demonstrated increased infection rates most likely due to reactivation of the virus. Prophylaxis had no impact on the incidence of infection but reduced the severity.
AB - Analysis of a historic renal transplant population for risks of developing CMV disease demonstrated a low mortality (0.2%) and morbidity. In our population of 1,959 patients, 411 (21%) developed subclinical CMV infection and 220 (11%) had CMV disease which was severe in 41 (2%). Important factors for infection were baseline immunosuppression, indicating that triple therapy with the proliferation inhibitors, azathioprine and MMF, had significantly higher infection numbers in comparison to dual, CsA-based immunosuppression. The cumulative dose of steroids correlated strongly with an increased number of CMV infections and disease, as did the addition of ALG/ATG or OKT3 for either steroid-resistant rejections or induction therapy. While CMV serology had an impact on infection in cases of seropositive donors to seronegative recipients, seropositive patients, in general, demonstrated increased infection rates most likely due to reactivation of the virus. Prophylaxis had no impact on the incidence of infection but reduced the severity.
M3 - SCORING: Zeitschriftenaufsatz
SP - 181
EP - 188
JO - CLIN TRANSPLANT
JF - CLIN TRANSPLANT
SN - 0902-0063
ER -
