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CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy

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CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy. / Keil, Laura; Chevalier, Céleste; Kirchhof, Paulus; Blankenberg, Stefan; Lund, Gunnar; Müllerleile, Kai; Magnussen, Christina.

In: INT J MOL SCI, Vol. 22, No. 13, 7115, 01.07.2021.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Keil, L, Chevalier, C, Kirchhof, P, Blankenberg, S, Lund, G, Müllerleile, K & Magnussen, C 2021, 'CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy', INT J MOL SCI, vol. 22, no. 13, 7115. https://doi.org/10.3390/ijms22137115

APA

Keil, L., Chevalier, C., Kirchhof, P., Blankenberg, S., Lund, G., Müllerleile, K., & Magnussen, C. (2021). CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy. INT J MOL SCI, 22(13), [7115]. https://doi.org/10.3390/ijms22137115

Vancouver

Keil L, Chevalier C, Kirchhof P, Blankenberg S, Lund G, Müllerleile K et al. CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy. INT J MOL SCI. 2021 Jul 1;22(13). 7115. https://doi.org/10.3390/ijms22137115

Bibtex

@article{91296035bbd04857b6cf2b730f4271c6,
title = "CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy",
abstract = "Non-ischemic cardiomyopathy (NICM) is one of the most important entities for arrhythmias and sudden cardiac death (SCD). Previous studies suggest a lower benefit of implantable cardioverter-defibrillator (ICD) therapy in patients with NICM as compared to ischemic cardiomyopathy (ICM). Nevertheless, current guidelines do not differentiate between the two subgroups in recommending ICD implantation. Hence, risk stratification is required to determine the subgroup of patients with NICM who will likely benefit from ICD therapy. Various predictors have been proposed, among others genetic mutations, left-ventricular ejection fraction (LVEF), left-ventricular end-diastolic volume (LVEDD), and T-wave alternans (TWA). In addition to these parameters, cardiovascular magnetic resonance imaging (CMR) has the potential to further improve risk stratification. CMR allows the comprehensive analysis of cardiac function and myocardial tissue composition. A range of CMR parameters have been associated with SCD. Applicable examples include late gadolinium enhancement (LGE), T1 relaxation times, and myocardial strain. This review evaluates the epidemiological aspects of SCD in NICM, the role of CMR for risk stratification, and resulting indications for ICD implantation.",
keywords = "Arrhythmias, Cardiac/pathology, Cardiomyopathies/classification, Cardiomyopathy, Dilated/complications, Contrast Media, Death, Sudden, Cardiac/epidemiology, Defibrillators, Implantable/statistics & numerical data, Humans, Magnetic Resonance Imaging/methods, Myocardial Ischemia/complications, Myocardium/pathology, Predictive Value of Tests, Risk Assessment/methods, Risk Factors, Stroke Volume, Ventricular Function, Left",
author = "Laura Keil and C{\'e}leste Chevalier and Paulus Kirchhof and Stefan Blankenberg and Gunnar Lund and Kai M{\"u}llerleile and Christina Magnussen",
year = "2021",
month = jul,
day = "1",
doi = "10.3390/ijms22137115",
language = "English",
volume = "22",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "13",

}

RIS

TY - JOUR

T1 - CMR-Based Risk Stratification of Sudden Cardiac Death and Use of Implantable Cardioverter-Defibrillator in Non-Ischemic Cardiomyopathy

AU - Keil, Laura

AU - Chevalier, Céleste

AU - Kirchhof, Paulus

AU - Blankenberg, Stefan

AU - Lund, Gunnar

AU - Müllerleile, Kai

AU - Magnussen, Christina

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Non-ischemic cardiomyopathy (NICM) is one of the most important entities for arrhythmias and sudden cardiac death (SCD). Previous studies suggest a lower benefit of implantable cardioverter-defibrillator (ICD) therapy in patients with NICM as compared to ischemic cardiomyopathy (ICM). Nevertheless, current guidelines do not differentiate between the two subgroups in recommending ICD implantation. Hence, risk stratification is required to determine the subgroup of patients with NICM who will likely benefit from ICD therapy. Various predictors have been proposed, among others genetic mutations, left-ventricular ejection fraction (LVEF), left-ventricular end-diastolic volume (LVEDD), and T-wave alternans (TWA). In addition to these parameters, cardiovascular magnetic resonance imaging (CMR) has the potential to further improve risk stratification. CMR allows the comprehensive analysis of cardiac function and myocardial tissue composition. A range of CMR parameters have been associated with SCD. Applicable examples include late gadolinium enhancement (LGE), T1 relaxation times, and myocardial strain. This review evaluates the epidemiological aspects of SCD in NICM, the role of CMR for risk stratification, and resulting indications for ICD implantation.

AB - Non-ischemic cardiomyopathy (NICM) is one of the most important entities for arrhythmias and sudden cardiac death (SCD). Previous studies suggest a lower benefit of implantable cardioverter-defibrillator (ICD) therapy in patients with NICM as compared to ischemic cardiomyopathy (ICM). Nevertheless, current guidelines do not differentiate between the two subgroups in recommending ICD implantation. Hence, risk stratification is required to determine the subgroup of patients with NICM who will likely benefit from ICD therapy. Various predictors have been proposed, among others genetic mutations, left-ventricular ejection fraction (LVEF), left-ventricular end-diastolic volume (LVEDD), and T-wave alternans (TWA). In addition to these parameters, cardiovascular magnetic resonance imaging (CMR) has the potential to further improve risk stratification. CMR allows the comprehensive analysis of cardiac function and myocardial tissue composition. A range of CMR parameters have been associated with SCD. Applicable examples include late gadolinium enhancement (LGE), T1 relaxation times, and myocardial strain. This review evaluates the epidemiological aspects of SCD in NICM, the role of CMR for risk stratification, and resulting indications for ICD implantation.

KW - Arrhythmias, Cardiac/pathology

KW - Cardiomyopathies/classification

KW - Cardiomyopathy, Dilated/complications

KW - Contrast Media

KW - Death, Sudden, Cardiac/epidemiology

KW - Defibrillators, Implantable/statistics & numerical data

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Myocardial Ischemia/complications

KW - Myocardium/pathology

KW - Predictive Value of Tests

KW - Risk Assessment/methods

KW - Risk Factors

KW - Stroke Volume

KW - Ventricular Function, Left

U2 - 10.3390/ijms22137115

DO - 10.3390/ijms22137115

M3 - SCORING: Review article

C2 - 34281168

VL - 22

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 13

M1 - 7115

ER -