Clouding of intraocular silicone oil in the absence of emulsification
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Clouding of intraocular silicone oil in the absence of emulsification. / Zheng, Ying; Willem de Vries, Jan; Herrmann, Andreas; Bartz-Schmidt, Karl-Ulrich; Dammeier, Sascha; Spitzer, Martin S.
In: Retinal cases & brief reports, Vol. 17, No. 2, 01.03.2023, p. 144-151.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Clouding of intraocular silicone oil in the absence of emulsification
AU - Zheng, Ying
AU - Willem de Vries, Jan
AU - Herrmann, Andreas
AU - Bartz-Schmidt, Karl-Ulrich
AU - Dammeier, Sascha
AU - Spitzer, Martin S
N1 - Copyright © 2021 by Ophthalmic Communications Society, Inc.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - PURPOSE: To describe intraocular clouding of silicone oil in the absence of emulsification.METHODS: Retrospective observational case series of patients who received silicone oil injections and developed silicone oil discoloration without emulsification after pars plana vitrectomy. Clinical examinations and physicochemical analyses were performed to find out the common cause for the opaque oil.RESULTS: Thirteen patients developed silicone oil discoloration after pars plana vitrectomy. It could be traced down that all patients had received silicone oil from one respective production batch. The silicone oil was removed as soon as possible after the changes were detected (range, 8-16 weeks). Gas chromatography flame ionization detector, size exclusion chromatography, and high-performance liquid chromatography analysis showed the absence of low-molecular-weight compounds in the opaque lot. Thermogravimetric analysis revealed the opaque lot was more temperature stable. During the follow-ups, no obvious retinal toxicity could be observed and best-recorded visual acuity improved considerably in 12 patients and was only limited by the underlying retinal pathologic conditions.CONCLUSION: This is the first report on opacification of intraocular silicone oil without emulsification. This discoloration of silicone oil may disturb vision and prevent proper fundus examination; however, it seems to be a nontoxic phenomenon without serious long-term consequences.
AB - PURPOSE: To describe intraocular clouding of silicone oil in the absence of emulsification.METHODS: Retrospective observational case series of patients who received silicone oil injections and developed silicone oil discoloration without emulsification after pars plana vitrectomy. Clinical examinations and physicochemical analyses were performed to find out the common cause for the opaque oil.RESULTS: Thirteen patients developed silicone oil discoloration after pars plana vitrectomy. It could be traced down that all patients had received silicone oil from one respective production batch. The silicone oil was removed as soon as possible after the changes were detected (range, 8-16 weeks). Gas chromatography flame ionization detector, size exclusion chromatography, and high-performance liquid chromatography analysis showed the absence of low-molecular-weight compounds in the opaque lot. Thermogravimetric analysis revealed the opaque lot was more temperature stable. During the follow-ups, no obvious retinal toxicity could be observed and best-recorded visual acuity improved considerably in 12 patients and was only limited by the underlying retinal pathologic conditions.CONCLUSION: This is the first report on opacification of intraocular silicone oil without emulsification. This discoloration of silicone oil may disturb vision and prevent proper fundus examination; however, it seems to be a nontoxic phenomenon without serious long-term consequences.
KW - Humans
KW - Retinal Detachment/surgery
KW - Retinal Diseases/etiology
KW - Retrospective Studies
KW - Silicone Oils/adverse effects
KW - Vitrectomy/methods
U2 - 10.1097/ICB.0000000000001123
DO - 10.1097/ICB.0000000000001123
M3 - SCORING: Journal article
C2 - 33492074
VL - 17
SP - 144
EP - 151
JO - Retinal cases & brief reports
JF - Retinal cases & brief reports
SN - 1935-1089
IS - 2
ER -