Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer.
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Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. / Wölber, Linn; Mahner, Sven; Voelker, Katharina; Zu Eulenburg, Christine Gräfin; Gieseking, Friederike; Choschzick, Matthias; Jänicke, Fritz; Schwarz, Joerg.
In: ANTICANCER RES, Vol. 29, No. 2, 2, 2009, p. 545-552.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer.
AU - Wölber, Linn
AU - Mahner, Sven
AU - Voelker, Katharina
AU - Zu Eulenburg, Christine Gräfin
AU - Gieseking, Friederike
AU - Choschzick, Matthias
AU - Jänicke, Fritz
AU - Schwarz, Joerg
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Vulvar cancer is a rare disease and knowledge on prognostic factors is therefore limited and inconsistent. The aim of this study was to determine prognostic variables for recurrence and survival and to identify patterns of recurrence in patients with vulvar cancer. PATIENTS AND METHODS: All patients (n = 103) with primary vulvar cancer treated at the University Medical Center Hamburg-Eppendorf between 1996 and 2003 were retrospectively analysed regarding the prognostic relevance of different clinicopathological variables. Recurrences were evaluated with regard to their characteristics and localisation. RESULTS: Age, lymph node metastasis, tumor size, depth of invasion and involvement of resection margins predicted poor disease-free and overall survival in univariate analysis. In multivariate analysis, lymph node status was the most important independent prognostic factor (p = 0.002). No correlation was observed between lymph node metastasis and localization of recurrent disease. Regardless of initial nodal involvement, recurrences occurred primarily in the vulvar region. CONCLUSION: Inguinofemoral lymph node status at initial diagnosis is of critical prognostic importance for patients with vulvar cancer. Further tumour biological characteristics need to be identified to stratify patients with nodal involvement for adjuvant radiotherapy of the vulva to prevent local recurrences.
AB - BACKGROUND: Vulvar cancer is a rare disease and knowledge on prognostic factors is therefore limited and inconsistent. The aim of this study was to determine prognostic variables for recurrence and survival and to identify patterns of recurrence in patients with vulvar cancer. PATIENTS AND METHODS: All patients (n = 103) with primary vulvar cancer treated at the University Medical Center Hamburg-Eppendorf between 1996 and 2003 were retrospectively analysed regarding the prognostic relevance of different clinicopathological variables. Recurrences were evaluated with regard to their characteristics and localisation. RESULTS: Age, lymph node metastasis, tumor size, depth of invasion and involvement of resection margins predicted poor disease-free and overall survival in univariate analysis. In multivariate analysis, lymph node status was the most important independent prognostic factor (p = 0.002). No correlation was observed between lymph node metastasis and localization of recurrent disease. Regardless of initial nodal involvement, recurrences occurred primarily in the vulvar region. CONCLUSION: Inguinofemoral lymph node status at initial diagnosis is of critical prognostic importance for patients with vulvar cancer. Further tumour biological characteristics need to be identified to stratify patients with nodal involvement for adjuvant radiotherapy of the vulva to prevent local recurrences.
M3 - SCORING: Zeitschriftenaufsatz
VL - 29
SP - 545
EP - 552
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 2
M1 - 2
ER -
