Clinical Use of Placebo Effects in Patients With Pain Disorders
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Clinical Use of Placebo Effects in Patients With Pain Disorders. / Klinger, Regine; Stuhlreyer, Julia Paula; Schwartz, Marie Christine; Schmitz, Julia ; Colloca, Luana.
International Review of Neurobiology: Neurobiology of the Placebo Effect Part II. ed. / Luana Colloca. Vol. 139 1. ed. Academic Press, 2018. p. 107-128 5 (International review of neurobiology).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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TY - CHAP
T1 - Clinical Use of Placebo Effects in Patients With Pain Disorders
AU - Klinger, Regine
AU - Stuhlreyer, Julia Paula
AU - Schwartz, Marie Christine
AU - Schmitz, Julia
AU - Colloca, Luana
N1 - © 2018 Elsevier Inc. All rights reserved.
PY - 2018/8/23
Y1 - 2018/8/23
N2 - The analgesic placebo effect is well documented by numerous studies. Many important influencing factors, however, are yet to be discovered. In the arena of placebo effects and clinical implications, expectancies play a central role. Expectancies are shaped by processes of classical and social learning as well as verbal instructions and are strongly related to emotional factors. Expectancies trigger a cascade of endogenous opioids and non-opioids, which alter the experience of pain. For clinical application it is important to know, that placebo research yields ethical possibilities to use placebo effects without deception and without using placebos. Since placebo effects contribute to responses to active analgesics, it is feasible to enhance patients' benefits from pain treatments by increasing the additional placebo effect. There are several possibilities to use the placebo effects via shaping and adapting information about analgesic medication and via associating medication intake with a positive context. A positive patient-clinician communication atmosphere is very important to generate clinically meaningful placebo effects in pain medicine.
AB - The analgesic placebo effect is well documented by numerous studies. Many important influencing factors, however, are yet to be discovered. In the arena of placebo effects and clinical implications, expectancies play a central role. Expectancies are shaped by processes of classical and social learning as well as verbal instructions and are strongly related to emotional factors. Expectancies trigger a cascade of endogenous opioids and non-opioids, which alter the experience of pain. For clinical application it is important to know, that placebo research yields ethical possibilities to use placebo effects without deception and without using placebos. Since placebo effects contribute to responses to active analgesics, it is feasible to enhance patients' benefits from pain treatments by increasing the additional placebo effect. There are several possibilities to use the placebo effects via shaping and adapting information about analgesic medication and via associating medication intake with a positive context. A positive patient-clinician communication atmosphere is very important to generate clinically meaningful placebo effects in pain medicine.
U2 - https://doi.org/10.1016/bs.irn.2018.07.015
DO - https://doi.org/10.1016/bs.irn.2018.07.015
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-0128154168
VL - 139
T3 - International review of neurobiology
SP - 107
EP - 128
BT - International Review of Neurobiology
A2 - Colloca, Luana
PB - Academic Press
ER -
