Clinical relevance and biology of circulating tumor cells.
Standard
Clinical relevance and biology of circulating tumor cells. / Bednarz, Natalia; Alix-Panabières, Catherine; Pantel, Klaus.
In: BREAST CANCER RES, Vol. 13, No. 6, 6, 2011, p. 228.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Clinical relevance and biology of circulating tumor cells.
AU - Bednarz, Natalia
AU - Alix-Panabières, Catherine
AU - Pantel, Klaus
PY - 2011
Y1 - 2011
N2 - Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.
AB - Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.
U2 - 10.1186/bcr2940
DO - 10.1186/bcr2940
M3 - SCORING: Journal article
VL - 13
SP - 228
JO - BREAST CANCER RES
JF - BREAST CANCER RES
SN - 1465-5411
IS - 6
M1 - 6
ER -