Clinical relevance and biology of circulating tumor cells.

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Clinical relevance and biology of circulating tumor cells. / Bednarz, Natalia; Alix-Panabières, Catherine; Pantel, Klaus.

In: BREAST CANCER RES, Vol. 13, No. 6, 6, 2011, p. 228.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{6f2c2badf4694e3d8c9310ddcafc7f19,
title = "Clinical relevance and biology of circulating tumor cells.",
abstract = "Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.",
author = "Natalia Bednarz and Catherine Alix-Panabi{\`e}res and Klaus Pantel",
year = "2011",
doi = "10.1186/bcr2940",
language = "English",
volume = "13",
pages = "228",
journal = "BREAST CANCER RES",
issn = "1465-5411",
publisher = "BioMed Central Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Clinical relevance and biology of circulating tumor cells.

AU - Bednarz, Natalia

AU - Alix-Panabières, Catherine

AU - Pantel, Klaus

PY - 2011

Y1 - 2011

N2 - Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.

AB - Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.

U2 - 10.1186/bcr2940

DO - 10.1186/bcr2940

M3 - SCORING: Journal article

VL - 13

SP - 228

JO - BREAST CANCER RES

JF - BREAST CANCER RES

SN - 1465-5411

IS - 6

M1 - 6

ER -