Research ExplorerPublicationsClinical performance of serum isoform [-2]proPSA (p2PSA), an...

Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study

Standard

Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study. / Fossati, Nicola; Lazzeri, Massimo; Haese, Alexander; McNicholas, Thomas; de la Taille, Alexandre; Buffi, Nicolò Maria; Lughezzani, Giovanni; Gadda, Giulio Maria; Lista, Giuliana; Larcher, Alessandro; Abrate, Alberto; Mistretta, Francesco; Bini, Vittorio; Redorta, Joan Palou; Graefen, Markus; Guazzoni, Giorgio.

In: BJU INT, 06.2015.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fossati, N, Lazzeri, M, Haese, A, McNicholas, T, de la Taille, A, Buffi, NM, Lughezzani, G, Gadda, GM, Lista, G, Larcher, A, Abrate, A, Mistretta, F, Bini, V, Redorta, JP, Graefen, M & Guazzoni, G 2015, 'Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study', BJU INT. https://doi.org/10.1111/bju.12718

APA

Fossati, N., Lazzeri, M., Haese, A., McNicholas, T., de la Taille, A., Buffi, N. M., Lughezzani, G., Gadda, G. M., Lista, G., Larcher, A., Abrate, A., Mistretta, F., Bini, V., Redorta, J. P., Graefen, M., & Guazzoni, G. (2015). Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study. BJU INT. https://doi.org/10.1111/bju.12718

Vancouver

Fossati N, Lazzeri M, Haese A, McNicholas T, de la Taille A, Buffi NM et al. Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study. BJU INT. 2015 Jun. https://doi.org/10.1111/bju.12718

Bibtex

@article{399b344801f34364b1e9f965173066fd,
title = "Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study",
abstract = "OBJECTIVES: To test the hypothesis that [-2]proPSA (p2PSA) and its derivatives are more accurate than total prostate-specific antigen (tPSA), free prostate-specific antigen (fPSA) and fPSA as percentage of tPSA (%fPSA) in detecting prostate cancer (PCa) in men aged <60 years.PATIENTS AND METHODS: The analysis consisted of a nested case-control study from the PRO- PSA Multicentric European Study (PROMEtheuS) project. The primary outcomes were measures of sensibility, specificity and accuracy of serum p2PSA, p2PSA as percentage of fPSA (%p2PSA) and Beckman Coulter prostate health index (PHI) in men aged <60 years who had undergone a prostate biopsy. The potential reduction in the number of unnecessary biopsies and the characteristics of the potentially missed PCa cases were reported as secondary outcomes. Multivariate logistic regression models were complemented by predictive accuracy and decision-curve analyses.RESULTS: Of the 1036 patients enrolled in the PROMEtheus project, 238 (22.9%) were aged < 60 years. PCa was found in 67 subjects (28.1%); p2PSA, %p2PSA and PHI values were significantly higher (P < 0.001) among these subjects, while no differences were found in tPSA, fPSA and %fPSA values. On univariate analysis, %p2PSA (area under the curve [AUC]: 0.704) and PHI (AUC: 0.7) were the most accurate predictors, and these significantly outperformed tPSA (AUC: 0.549), fPSA (AUC: 0.511) and %fPSA (AUC: 0.557) in the prediction of PCa at biopsy (P ≤ 0.001). In multivariate logistic regression models, %p2PSA and PHI achieved independent predictor status and significantly increased the accuracy of multivariate models by 6.3 and 7.6%, respectively (P ≤ 0.05).CONCLUSION: PHI and %p2PSA are more accurate than the reference standard tests in predicting PCa in young men.",
author = "Nicola Fossati and Massimo Lazzeri and Alexander Haese and Thomas McNicholas and {de la Taille}, Alexandre and Buffi, {Nicol{\`o} Maria} and Giovanni Lughezzani and Gadda, {Giulio Maria} and Giuliana Lista and Alessandro Larcher and Alberto Abrate and Francesco Mistretta and Vittorio Bini and Redorta, {Joan Palou} and Markus Graefen and Giorgio Guazzoni",
note = "{\textcopyright} 2014 The Authors BJU International {\textcopyright} 2014 BJU International.",
year = "2015",
month = jun,
doi = "10.1111/bju.12718",
language = "English",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Clinical performance of serum isoform [-2]proPSA (p2PSA), and its derivatives %p2PSA and the Prostate Health Index, in men aged <60 years: results from a multicentric European study

AU - Fossati, Nicola

AU - Lazzeri, Massimo

AU - Haese, Alexander

AU - McNicholas, Thomas

AU - de la Taille, Alexandre

AU - Buffi, Nicolò Maria

AU - Lughezzani, Giovanni

AU - Gadda, Giulio Maria

AU - Lista, Giuliana

AU - Larcher, Alessandro

AU - Abrate, Alberto

AU - Mistretta, Francesco

AU - Bini, Vittorio

AU - Redorta, Joan Palou

AU - Graefen, Markus

AU - Guazzoni, Giorgio

N1 - © 2014 The Authors BJU International © 2014 BJU International.

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVES: To test the hypothesis that [-2]proPSA (p2PSA) and its derivatives are more accurate than total prostate-specific antigen (tPSA), free prostate-specific antigen (fPSA) and fPSA as percentage of tPSA (%fPSA) in detecting prostate cancer (PCa) in men aged <60 years.PATIENTS AND METHODS: The analysis consisted of a nested case-control study from the PRO- PSA Multicentric European Study (PROMEtheuS) project. The primary outcomes were measures of sensibility, specificity and accuracy of serum p2PSA, p2PSA as percentage of fPSA (%p2PSA) and Beckman Coulter prostate health index (PHI) in men aged <60 years who had undergone a prostate biopsy. The potential reduction in the number of unnecessary biopsies and the characteristics of the potentially missed PCa cases were reported as secondary outcomes. Multivariate logistic regression models were complemented by predictive accuracy and decision-curve analyses.RESULTS: Of the 1036 patients enrolled in the PROMEtheus project, 238 (22.9%) were aged < 60 years. PCa was found in 67 subjects (28.1%); p2PSA, %p2PSA and PHI values were significantly higher (P < 0.001) among these subjects, while no differences were found in tPSA, fPSA and %fPSA values. On univariate analysis, %p2PSA (area under the curve [AUC]: 0.704) and PHI (AUC: 0.7) were the most accurate predictors, and these significantly outperformed tPSA (AUC: 0.549), fPSA (AUC: 0.511) and %fPSA (AUC: 0.557) in the prediction of PCa at biopsy (P ≤ 0.001). In multivariate logistic regression models, %p2PSA and PHI achieved independent predictor status and significantly increased the accuracy of multivariate models by 6.3 and 7.6%, respectively (P ≤ 0.05).CONCLUSION: PHI and %p2PSA are more accurate than the reference standard tests in predicting PCa in young men.

AB - OBJECTIVES: To test the hypothesis that [-2]proPSA (p2PSA) and its derivatives are more accurate than total prostate-specific antigen (tPSA), free prostate-specific antigen (fPSA) and fPSA as percentage of tPSA (%fPSA) in detecting prostate cancer (PCa) in men aged <60 years.PATIENTS AND METHODS: The analysis consisted of a nested case-control study from the PRO- PSA Multicentric European Study (PROMEtheuS) project. The primary outcomes were measures of sensibility, specificity and accuracy of serum p2PSA, p2PSA as percentage of fPSA (%p2PSA) and Beckman Coulter prostate health index (PHI) in men aged <60 years who had undergone a prostate biopsy. The potential reduction in the number of unnecessary biopsies and the characteristics of the potentially missed PCa cases were reported as secondary outcomes. Multivariate logistic regression models were complemented by predictive accuracy and decision-curve analyses.RESULTS: Of the 1036 patients enrolled in the PROMEtheus project, 238 (22.9%) were aged < 60 years. PCa was found in 67 subjects (28.1%); p2PSA, %p2PSA and PHI values were significantly higher (P < 0.001) among these subjects, while no differences were found in tPSA, fPSA and %fPSA values. On univariate analysis, %p2PSA (area under the curve [AUC]: 0.704) and PHI (AUC: 0.7) were the most accurate predictors, and these significantly outperformed tPSA (AUC: 0.549), fPSA (AUC: 0.511) and %fPSA (AUC: 0.557) in the prediction of PCa at biopsy (P ≤ 0.001). In multivariate logistic regression models, %p2PSA and PHI achieved independent predictor status and significantly increased the accuracy of multivariate models by 6.3 and 7.6%, respectively (P ≤ 0.05).CONCLUSION: PHI and %p2PSA are more accurate than the reference standard tests in predicting PCa in young men.

U2 - 10.1111/bju.12718

DO - 10.1111/bju.12718

M3 - SCORING: Journal article

C2 - 24589357

JO - BJU INT

JF - BJU INT

SN - 1464-4096

ER -