Clinical management of epithelial ovarian cancer during pregnancy
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Clinical management of epithelial ovarian cancer during pregnancy. / Grimm, Donata; Woelber, Linn; Trillsch, Fabian; Keller-v. Amsberg, Gunhild; Mahner, Sven.
In: EUR J CANCER, Vol. 50, No. 5, 01.03.2014, p. 963-971.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical management of epithelial ovarian cancer during pregnancy
AU - Grimm, Donata
AU - Woelber, Linn
AU - Trillsch, Fabian
AU - Keller-v. Amsberg, Gunhild
AU - Mahner, Sven
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - UNLABELLED: Epithelial ovarian cancer (EOC) in pregnancy is a rare situation. Due to its low incidence with a consecutive lack of clinical trials many questions regarding indication of different treatment approaches are unanswered. This article discusses the current literature to elaborate recommendations for the management of EOC during pregnancy. A literature search of diagnostic approaches and treatment strategies for EOC complicated by pregnancy was performed. We reviewed the available information with emphasis on surgery as well as chemotherapeutical treatment options. EOC in pregnancy is often diagnosed at early stage and no data support that concurrent pregnancy influences the growth rate or propensity for spread of EOC. Radical cytoreduction of all visible tumour followed by subsequent systemic chemotherapy is the standard treatment of EOC in most non-pregnant women. In pregnant women, however, chemotherapy as well as radical surgery should be avoided in the first trimester because of teratogenesis and high abortion rates. Besides induced abortion followed by classic management of EOC, pregnancy preserving surgery, followed by chemotherapy in the second or third trimester, timely delivery as well as neo-adjuvant chemotherapy with subsequent completing surgery appear to be viable treatment options.CONCLUSIONS: Since there is only very limited information regarding the optimal therapeutic approach to EOC during pregnancy, each case needs to be addressed individually. Treatment in specialised centres should be intended especially in this rare and challenging situation.
AB - UNLABELLED: Epithelial ovarian cancer (EOC) in pregnancy is a rare situation. Due to its low incidence with a consecutive lack of clinical trials many questions regarding indication of different treatment approaches are unanswered. This article discusses the current literature to elaborate recommendations for the management of EOC during pregnancy. A literature search of diagnostic approaches and treatment strategies for EOC complicated by pregnancy was performed. We reviewed the available information with emphasis on surgery as well as chemotherapeutical treatment options. EOC in pregnancy is often diagnosed at early stage and no data support that concurrent pregnancy influences the growth rate or propensity for spread of EOC. Radical cytoreduction of all visible tumour followed by subsequent systemic chemotherapy is the standard treatment of EOC in most non-pregnant women. In pregnant women, however, chemotherapy as well as radical surgery should be avoided in the first trimester because of teratogenesis and high abortion rates. Besides induced abortion followed by classic management of EOC, pregnancy preserving surgery, followed by chemotherapy in the second or third trimester, timely delivery as well as neo-adjuvant chemotherapy with subsequent completing surgery appear to be viable treatment options.CONCLUSIONS: Since there is only very limited information regarding the optimal therapeutic approach to EOC during pregnancy, each case needs to be addressed individually. Treatment in specialised centres should be intended especially in this rare and challenging situation.
KW - Antineoplastic Agents
KW - Combined Modality Therapy
KW - Female
KW - Humans
KW - Neoplasms, Glandular and Epithelial
KW - Ovarian Neoplasms
KW - Ovariectomy
KW - Pregnancy
KW - Pregnancy Complications, Neoplastic
KW - Pregnancy Outcome
KW - Treatment Outcome
U2 - 10.1016/j.ejca.2013.12.020
DO - 10.1016/j.ejca.2013.12.020
M3 - SCORING: Journal article
C2 - 24462638
VL - 50
SP - 963
EP - 971
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 5
ER -