Research ExplorerPublicationsClinical high risk for psychosis gender differences in sympt...

Clinical high risk for psychosis gender differences in symptoms and social functioning

Standard

Clinical high risk for psychosis gender differences in symptoms and social functioning. / Rietschel, Liz; Lambert, Martin; Karow, Anne; Zink, Mathias; Müller, Hendrik; Heinz, Andreas; de Millas, Walter; Janssen, Birgit; Gaebel, Wolfgang; Schneider, Frank; Naber, Dieter; Juckel, Georg; Krüger-Özgürdal, Seza; Wobrock, Thomas; Wagner, Michael; Maier, Wolfgang; Klosterkötter, Joachim; Bechdolf, Andreas; PREVENT study group.

In: EARLY INTERV PSYCHIA, 24.03.2015.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rietschel, L, Lambert, M, Karow, A, Zink, M, Müller, H, Heinz, A, de Millas, W, Janssen, B, Gaebel, W, Schneider, F, Naber, D, Juckel, G, Krüger-Özgürdal, S, Wobrock, T, Wagner, M, Maier, W, Klosterkötter, J, Bechdolf, A & PREVENT study group 2015, 'Clinical high risk for psychosis gender differences in symptoms and social functioning', EARLY INTERV PSYCHIA. https://doi.org/10.1111/eip.12240

APA

Rietschel, L., Lambert, M., Karow, A., Zink, M., Müller, H., Heinz, A., de Millas, W., Janssen, B., Gaebel, W., Schneider, F., Naber, D., Juckel, G., Krüger-Özgürdal, S., Wobrock, T., Wagner, M., Maier, W., Klosterkötter, J., Bechdolf, A., & PREVENT study group (2015). Clinical high risk for psychosis gender differences in symptoms and social functioning. EARLY INTERV PSYCHIA. https://doi.org/10.1111/eip.12240

Vancouver

Rietschel L, Lambert M, Karow A, Zink M, Müller H, Heinz A et al. Clinical high risk for psychosis gender differences in symptoms and social functioning. EARLY INTERV PSYCHIA. 2015 Mar 24. https://doi.org/10.1111/eip.12240

Bibtex

@article{d04e2a281d2f4a0caef21b4f23a0a13b,
title = "Clinical high risk for psychosis gender differences in symptoms and social functioning",
abstract = "AIM: Schizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question.METHODS: Clinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n = 80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS).RESULTS: Men displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria.CONCLUSION: The higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.",
author = "Liz Rietschel and Martin Lambert and Anne Karow and Mathias Zink and Hendrik M{\"u}ller and Andreas Heinz and {de Millas}, Walter and Birgit Janssen and Wolfgang Gaebel and Frank Schneider and Dieter Naber and Georg Juckel and Seza Kr{\"u}ger-{\"O}zg{\"u}rdal and Thomas Wobrock and Michael Wagner and Wolfgang Maier and Joachim Klosterk{\"o}tter and Andreas Bechdolf and {PREVENT study group}",
note = "{\textcopyright} 2015 Wiley Publishing Asia Pty Ltd.",
year = "2015",
month = mar,
day = "24",
doi = "10.1111/eip.12240",
language = "English",
journal = "EARLY INTERV PSYCHIA",
issn = "1751-7885",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Clinical high risk for psychosis gender differences in symptoms and social functioning

AU - Rietschel, Liz

AU - Lambert, Martin

AU - Karow, Anne

AU - Zink, Mathias

AU - Müller, Hendrik

AU - Heinz, Andreas

AU - de Millas, Walter

AU - Janssen, Birgit

AU - Gaebel, Wolfgang

AU - Schneider, Frank

AU - Naber, Dieter

AU - Juckel, Georg

AU - Krüger-Özgürdal, Seza

AU - Wobrock, Thomas

AU - Wagner, Michael

AU - Maier, Wolfgang

AU - Klosterkötter, Joachim

AU - Bechdolf, Andreas

AU - PREVENT study group

N1 - © 2015 Wiley Publishing Asia Pty Ltd.

PY - 2015/3/24

Y1 - 2015/3/24

N2 - AIM: Schizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question.METHODS: Clinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n = 80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS).RESULTS: Men displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria.CONCLUSION: The higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.

AB - AIM: Schizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question.METHODS: Clinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n = 80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS).RESULTS: Men displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria.CONCLUSION: The higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.

U2 - 10.1111/eip.12240

DO - 10.1111/eip.12240

M3 - SCORING: Journal article

C2 - 25808791

JO - EARLY INTERV PSYCHIA

JF - EARLY INTERV PSYCHIA

SN - 1751-7885

ER -