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Clinical frailty scale and outcome after coronary artery bypass grafting

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Clinical frailty scale and outcome after coronary artery bypass grafting. / Reichart, Daniel; Rosato, Stefano; Nammas, Wail; Onorati, Francesco; Dalén, Magnus; Castro, Liesa; Gherli, Riccardo; Gatti, Giuseppe; Franzese, Ilaria; Faggian, Giuseppe; De Feo, Marisa; Khodabandeh, Sorosh; Santarpino, Giuseppe; Rubino, Antonino S; Maselli, Daniele; Nardella, Saverio; Salsano, Antonio; Nicolini, Francesco; Zanobini, Marco; Saccocci, Matteo; Bounader, Karl; Kinnunen, Eeva-Maija; Tauriainen, Tuomas; Airaksinen, Juhani; Seccareccia, Fulvia; Mariscalco, Giovanni; Ruggieri, Vito G; Perrotti, Andrea; Biancari, Fausto.

In: EUR J CARDIO-THORAC, Vol. 54, No. 6, 01.12.2018, p. 1102-1109.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reichart, D, Rosato, S, Nammas, W, Onorati, F, Dalén, M, Castro, L, Gherli, R, Gatti, G, Franzese, I, Faggian, G, De Feo, M, Khodabandeh, S, Santarpino, G, Rubino, AS, Maselli, D, Nardella, S, Salsano, A, Nicolini, F, Zanobini, M, Saccocci, M, Bounader, K, Kinnunen, E-M, Tauriainen, T, Airaksinen, J, Seccareccia, F, Mariscalco, G, Ruggieri, VG, Perrotti, A & Biancari, F 2018, 'Clinical frailty scale and outcome after coronary artery bypass grafting', EUR J CARDIO-THORAC, vol. 54, no. 6, pp. 1102-1109. https://doi.org/10.1093/ejcts/ezy222

APA

Reichart, D., Rosato, S., Nammas, W., Onorati, F., Dalén, M., Castro, L., Gherli, R., Gatti, G., Franzese, I., Faggian, G., De Feo, M., Khodabandeh, S., Santarpino, G., Rubino, A. S., Maselli, D., Nardella, S., Salsano, A., Nicolini, F., Zanobini, M., ... Biancari, F. (2018). Clinical frailty scale and outcome after coronary artery bypass grafting. EUR J CARDIO-THORAC, 54(6), 1102-1109. https://doi.org/10.1093/ejcts/ezy222

Vancouver

Reichart D, Rosato S, Nammas W, Onorati F, Dalén M, Castro L et al. Clinical frailty scale and outcome after coronary artery bypass grafting. EUR J CARDIO-THORAC. 2018 Dec 1;54(6):1102-1109. https://doi.org/10.1093/ejcts/ezy222

Bibtex

@article{409742676cee4465af35f225ffab7ec7,
title = "Clinical frailty scale and outcome after coronary artery bypass grafting",
abstract = "OBJECTIVES: The aim of this study was to assess the impact of frailty on the outcome after coronary artery bypass grafting (CABG) and whether it may improve the predictive ability of European System for Cardiac Operative Risk Evaluation (EuroSCORE II).METHODS: The Clinical Frailty Scale (CFS) was assessed preoperatively in patients undergoing isolated CABG from the multicentre E-CABG registry, and patients were stratified into 3 classes: scores 1-2, scores 3-4 and scores 5-7.RESULTS: Of the 6156 patients enrolled, 39.2% had CFS scores 1-2, 57.6% scores 3-4, and 3.2% scores 5-7. Logistic regression adjusted for multiple covariates showed that the CFS was an independent predictor of hospital/30-day mortality [CFS scores 3-4, odds ratio (OR) 3.95, 95% confidence interval (CI) 2.19-7.14; CFS scores 5-7, OR 5.90, 95% CI 2.67-13.05] and resulted in an Integrated Improvement Index of 1.3 (P < 0.001) and a Net Reclassification Index of 55.6 (P < 0.001) for prediction of hospital/30-day mortality. Adding the CFS classes to EuroSCORE II resulted in an Integrated Improvement Index of 0.9 (P < 0.001) and Net Reclassification Index of 59.6 (P < 0.001) for prediction of hospital/30-day mortality with a significantly larger area under the receiver operating characteristics curve (0.809 vs 0.781, P = 0.028). The CFS was an independent predictor of mid-term mortality [CFS scores 3-4, hazard ratio (HR) 2.05, 95% CI 1.43-2.85; CFS scores 5-7, HR 3.05, 95% CI 1.83-5.06].CONCLUSIONS: The CFS predicted early- and mid-term mortality in patients undergoing isolated CABG. Further studies are needed to evaluate whether frailty may improve the estimation of the operative risk of patients undergoing adult cardiac surgery.Clinicaltrials.gov number: NCT02319083.",
keywords = "Aged, Coronary Artery Bypass/mortality, Female, Frailty/classification, Humans, Male, Middle Aged, Prospective Studies, Severity of Illness Index, Treatment Outcome",
author = "Daniel Reichart and Stefano Rosato and Wail Nammas and Francesco Onorati and Magnus Dal{\'e}n and Liesa Castro and Riccardo Gherli and Giuseppe Gatti and Ilaria Franzese and Giuseppe Faggian and {De Feo}, Marisa and Sorosh Khodabandeh and Giuseppe Santarpino and Rubino, {Antonino S} and Daniele Maselli and Saverio Nardella and Antonio Salsano and Francesco Nicolini and Marco Zanobini and Matteo Saccocci and Karl Bounader and Eeva-Maija Kinnunen and Tuomas Tauriainen and Juhani Airaksinen and Fulvia Seccareccia and Giovanni Mariscalco and Ruggieri, {Vito G} and Andrea Perrotti and Fausto Biancari",
year = "2018",
month = dec,
day = "1",
doi = "10.1093/ejcts/ezy222",
language = "English",
volume = "54",
pages = "1102--1109",
journal = "EUR J CARDIO-THORAC",
issn = "1010-7940",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Clinical frailty scale and outcome after coronary artery bypass grafting

AU - Reichart, Daniel

AU - Rosato, Stefano

AU - Nammas, Wail

AU - Onorati, Francesco

AU - Dalén, Magnus

AU - Castro, Liesa

AU - Gherli, Riccardo

AU - Gatti, Giuseppe

AU - Franzese, Ilaria

AU - Faggian, Giuseppe

AU - De Feo, Marisa

AU - Khodabandeh, Sorosh

AU - Santarpino, Giuseppe

AU - Rubino, Antonino S

AU - Maselli, Daniele

AU - Nardella, Saverio

AU - Salsano, Antonio

AU - Nicolini, Francesco

AU - Zanobini, Marco

AU - Saccocci, Matteo

AU - Bounader, Karl

AU - Kinnunen, Eeva-Maija

AU - Tauriainen, Tuomas

AU - Airaksinen, Juhani

AU - Seccareccia, Fulvia

AU - Mariscalco, Giovanni

AU - Ruggieri, Vito G

AU - Perrotti, Andrea

AU - Biancari, Fausto

PY - 2018/12/1

Y1 - 2018/12/1

N2 - OBJECTIVES: The aim of this study was to assess the impact of frailty on the outcome after coronary artery bypass grafting (CABG) and whether it may improve the predictive ability of European System for Cardiac Operative Risk Evaluation (EuroSCORE II).METHODS: The Clinical Frailty Scale (CFS) was assessed preoperatively in patients undergoing isolated CABG from the multicentre E-CABG registry, and patients were stratified into 3 classes: scores 1-2, scores 3-4 and scores 5-7.RESULTS: Of the 6156 patients enrolled, 39.2% had CFS scores 1-2, 57.6% scores 3-4, and 3.2% scores 5-7. Logistic regression adjusted for multiple covariates showed that the CFS was an independent predictor of hospital/30-day mortality [CFS scores 3-4, odds ratio (OR) 3.95, 95% confidence interval (CI) 2.19-7.14; CFS scores 5-7, OR 5.90, 95% CI 2.67-13.05] and resulted in an Integrated Improvement Index of 1.3 (P < 0.001) and a Net Reclassification Index of 55.6 (P < 0.001) for prediction of hospital/30-day mortality. Adding the CFS classes to EuroSCORE II resulted in an Integrated Improvement Index of 0.9 (P < 0.001) and Net Reclassification Index of 59.6 (P < 0.001) for prediction of hospital/30-day mortality with a significantly larger area under the receiver operating characteristics curve (0.809 vs 0.781, P = 0.028). The CFS was an independent predictor of mid-term mortality [CFS scores 3-4, hazard ratio (HR) 2.05, 95% CI 1.43-2.85; CFS scores 5-7, HR 3.05, 95% CI 1.83-5.06].CONCLUSIONS: The CFS predicted early- and mid-term mortality in patients undergoing isolated CABG. Further studies are needed to evaluate whether frailty may improve the estimation of the operative risk of patients undergoing adult cardiac surgery.Clinicaltrials.gov number: NCT02319083.

AB - OBJECTIVES: The aim of this study was to assess the impact of frailty on the outcome after coronary artery bypass grafting (CABG) and whether it may improve the predictive ability of European System for Cardiac Operative Risk Evaluation (EuroSCORE II).METHODS: The Clinical Frailty Scale (CFS) was assessed preoperatively in patients undergoing isolated CABG from the multicentre E-CABG registry, and patients were stratified into 3 classes: scores 1-2, scores 3-4 and scores 5-7.RESULTS: Of the 6156 patients enrolled, 39.2% had CFS scores 1-2, 57.6% scores 3-4, and 3.2% scores 5-7. Logistic regression adjusted for multiple covariates showed that the CFS was an independent predictor of hospital/30-day mortality [CFS scores 3-4, odds ratio (OR) 3.95, 95% confidence interval (CI) 2.19-7.14; CFS scores 5-7, OR 5.90, 95% CI 2.67-13.05] and resulted in an Integrated Improvement Index of 1.3 (P < 0.001) and a Net Reclassification Index of 55.6 (P < 0.001) for prediction of hospital/30-day mortality. Adding the CFS classes to EuroSCORE II resulted in an Integrated Improvement Index of 0.9 (P < 0.001) and Net Reclassification Index of 59.6 (P < 0.001) for prediction of hospital/30-day mortality with a significantly larger area under the receiver operating characteristics curve (0.809 vs 0.781, P = 0.028). The CFS was an independent predictor of mid-term mortality [CFS scores 3-4, hazard ratio (HR) 2.05, 95% CI 1.43-2.85; CFS scores 5-7, HR 3.05, 95% CI 1.83-5.06].CONCLUSIONS: The CFS predicted early- and mid-term mortality in patients undergoing isolated CABG. Further studies are needed to evaluate whether frailty may improve the estimation of the operative risk of patients undergoing adult cardiac surgery.Clinicaltrials.gov number: NCT02319083.

KW - Aged

KW - Coronary Artery Bypass/mortality

KW - Female

KW - Frailty/classification

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Severity of Illness Index

KW - Treatment Outcome

U2 - 10.1093/ejcts/ezy222

DO - 10.1093/ejcts/ezy222

M3 - SCORING: Journal article

C2 - 29897529

VL - 54

SP - 1102

EP - 1109

JO - EUR J CARDIO-THORAC

JF - EUR J CARDIO-THORAC

SN - 1010-7940

IS - 6

ER -