Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer

Liesa Dziggel; Steven E Schild; Theo Veninga; Amira Bajrovic; Dirk Rades

doi:10.21873/invivo.11021

Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer

Standard

Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer. / Dziggel, Liesa; Schild, Steven E; Veninga, Theo; Bajrovic, Amira; Rades, Dirk.

In: IN VIVO, Vol. 31, No. 1, 02.01.2017, p. 35-38.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Dziggel, L, Schild, SE, Veninga, T, Bajrovic, A & Rades, D 2017, 'Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer', IN VIVO, vol. 31, no. 1, pp. 35-38. https://doi.org/10.21873/invivo.11021

APA

Dziggel, L., Schild, S. E., Veninga, T., Bajrovic, A., & Rades, D. (2017). Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer. IN VIVO, 31(1), 35-38. https://doi.org/10.21873/invivo.11021

Vancouver

Dziggel L, Schild SE, Veninga T, Bajrovic A, Rades D. Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer. IN VIVO. 2017 Jan 2;31(1):35-38. https://doi.org/10.21873/invivo.11021

Bibtex

@article{74b305dbd1dd45ce8b423abed3948998,

title = "Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer",

abstract = "BACKGROUND/AIM: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group.PATIENTS AND METHODS: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursive-partitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival.RESULTS: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival.CONCLUSION: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.",

keywords = "Review, Journal Article",

author = "Liesa Dziggel and Schild, {Steven E} and Theo Veninga and Amira Bajrovic and Dirk Rades",

year = "2017",

month = jan,

day = "2",

doi = "10.21873/invivo.11021",

language = "English",

volume = "31",

pages = "35--38",

journal = "IN VIVO",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "1",

}

RIS

TY - JOUR

T1 - Clinical Factors Asssociated with Treatment Outcomes following Whole-brain Irradiation in Patients with Prostate Cancer

AU - Dziggel, Liesa

AU - Schild, Steven E

AU - Veninga, Theo

AU - Bajrovic, Amira

AU - Rades, Dirk

PY - 2017/1/2

Y1 - 2017/1/2

N2 - BACKGROUND/AIM: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group.PATIENTS AND METHODS: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursive-partitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival.RESULTS: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival.CONCLUSION: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.

AB - BACKGROUND/AIM: Patients with prostate cancer represent a small minority of cancer patients presenting with metastases to the brain. This study investigated the role of whole-brain irradiation (WBI) in this rare group.PATIENTS AND METHODS: Eighteen such patients were included. Clinical factors including fractionation program of WBI, age at WBI, Karnofsky performance score (KPS), number of metastases to the brain, involvement of extracerebral metastatic sites, time from prostate cancer diagnosis to WBI and recursive-partitioning-analysis (RPA) class were investigated regarding local (intracerebral) control and survival.RESULTS: On multivariate evaluation, longer time from prostate cancer diagnosis to WBI showed a trend towards improved local control (hazard ratio 2.77, p=0.098). Better KPS (hazard ratio 5.64, p=0.021) and longer time from prostate cancer diagnosis to WBI (hazard ratio 5.64, p=0.013) were significantly associated with better survival.CONCLUSION: Two independent predictors of survival were identified and should be considered when designing for personalized treatment regimens and clinical trials.

KW - Review

KW - Journal Article

U2 - 10.21873/invivo.11021

DO - 10.21873/invivo.11021

M3 - SCORING: Review article

C2 - 28064217

VL - 31

SP - 35

EP - 38

JO - IN VIVO

JF - IN VIVO

SN - 0258-851X

IS - 1

ER -