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Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study

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Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. / Panova-Noeva, Marina; Schulz, Andreas; Spronk, Henri M; Beicht, Aline; Laubert-Reh, Dagmar; van Oerle, Rene; Arnold, Natalie; Prochaska, Jürgen H; Blettner, Maria; Beutel, Manfred; Pfeiffer, Norbert; Münzel, Thomas; Lackner, Karl J; Ten Cate, Hugo; Wild, Philipp S.

In: THROMB HAEMOSTASIS, Vol. 118, No. 5, 05.2018, p. 873-882.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Panova-Noeva, M, Schulz, A, Spronk, HM, Beicht, A, Laubert-Reh, D, van Oerle, R, Arnold, N, Prochaska, JH, Blettner, M, Beutel, M, Pfeiffer, N, Münzel, T, Lackner, KJ, Ten Cate, H & Wild, PS 2018, 'Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study', THROMB HAEMOSTASIS, vol. 118, no. 5, pp. 873-882. https://doi.org/10.1055/s-0038-1641565

APA

Panova-Noeva, M., Schulz, A., Spronk, H. M., Beicht, A., Laubert-Reh, D., van Oerle, R., Arnold, N., Prochaska, J. H., Blettner, M., Beutel, M., Pfeiffer, N., Münzel, T., Lackner, K. J., Ten Cate, H., & Wild, P. S. (2018). Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. THROMB HAEMOSTASIS, 118(5), 873-882. https://doi.org/10.1055/s-0038-1641565

Vancouver

Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R et al. Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. THROMB HAEMOSTASIS. 2018 May;118(5):873-882. https://doi.org/10.1055/s-0038-1641565

Bibtex

@article{e1a49053bc654f1a8f13e7a2f1166810,
title = "Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study",
abstract = "The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might be an important indicator of prothrombotic risk linked to cardiovascular disease (CVD), but the presence of platelets may be a critical determinant. Clinical data, laboratory markers and thrombin generation (TG), investigated in both platelet-rich plasma (PRP) and platelet-free plasma (PFP) at 1 pM TF, were available in 407 individuals from the Gutenberg Health Study. Given the well-known effect of anticoagulants on TG, subjects taking anticoagulants (n = 15) have been excluded resulting in 392 subjects for further analysis. Lag time, endogenous thrombin potential (ETP) and peak height were the investigated parameters of a TG curve. Multivariable linear regression analysis was used to identify TG determinants. Mean platelet volume (MPV) and platelet count were both negatively associated to lag time and positively to peak height (MPV, β:6.35 [2.66; 10.0]; platelet count, β:0.111 [0.054; 0.169]) in PRP only. C-reactive protein was positively associated with lag time and ETP in both PRP and PFP, with a stronger effect on ETP in PRP (PRP, β:76.7 [47.5; 106]; PFP, β:34.8 [10.3; 59.2]). After adjustment for fibrinogen, the relation between CRP and ETP was attenuated in PRP and PFP. Of the traditional cardiovascular risk factors (CVRFs), obesity was positively associated to TG in PRP only. Our findings support that TG, particularly in PRP, relates to traditional CVRFs in a representative sample from a population-based study. Assessment of procoagulant activity in a platelet-dependent manner by TG is a promising tool for assessing individual risk for CVD.",
keywords = "Adult, Aged, Blood Coagulation, Blood Coagulation Tests, Blood Platelets/enzymology, C-Reactive Protein/metabolism, Cardiovascular Diseases/blood, Female, Germany, Humans, Male, Mean Platelet Volume, Middle Aged, Platelet Count, Platelet-Rich Plasma/enzymology, Predictive Value of Tests, Prospective Studies, Risk Assessment, Risk Factors, Thrombin/metabolism, Time Factors",
author = "Marina Panova-Noeva and Andreas Schulz and Spronk, {Henri M} and Aline Beicht and Dagmar Laubert-Reh and {van Oerle}, Rene and Natalie Arnold and Prochaska, {J{\"u}rgen H} and Maria Blettner and Manfred Beutel and Norbert Pfeiffer and Thomas M{\"u}nzel and Lackner, {Karl J} and {Ten Cate}, Hugo and Wild, {Philipp S}",
note = "Schattauer GmbH Stuttgart.",
year = "2018",
month = may,
doi = "10.1055/s-0038-1641565",
language = "English",
volume = "118",
pages = "873--882",
journal = "THROMB HAEMOSTASIS",
issn = "0340-6245",
publisher = "Schattauer",
number = "5",

}

RIS

TY - JOUR

T1 - Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study

AU - Panova-Noeva, Marina

AU - Schulz, Andreas

AU - Spronk, Henri M

AU - Beicht, Aline

AU - Laubert-Reh, Dagmar

AU - van Oerle, Rene

AU - Arnold, Natalie

AU - Prochaska, Jürgen H

AU - Blettner, Maria

AU - Beutel, Manfred

AU - Pfeiffer, Norbert

AU - Münzel, Thomas

AU - Lackner, Karl J

AU - Ten Cate, Hugo

AU - Wild, Philipp S

N1 - Schattauer GmbH Stuttgart.

PY - 2018/5

Y1 - 2018/5

N2 - The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might be an important indicator of prothrombotic risk linked to cardiovascular disease (CVD), but the presence of platelets may be a critical determinant. Clinical data, laboratory markers and thrombin generation (TG), investigated in both platelet-rich plasma (PRP) and platelet-free plasma (PFP) at 1 pM TF, were available in 407 individuals from the Gutenberg Health Study. Given the well-known effect of anticoagulants on TG, subjects taking anticoagulants (n = 15) have been excluded resulting in 392 subjects for further analysis. Lag time, endogenous thrombin potential (ETP) and peak height were the investigated parameters of a TG curve. Multivariable linear regression analysis was used to identify TG determinants. Mean platelet volume (MPV) and platelet count were both negatively associated to lag time and positively to peak height (MPV, β:6.35 [2.66; 10.0]; platelet count, β:0.111 [0.054; 0.169]) in PRP only. C-reactive protein was positively associated with lag time and ETP in both PRP and PFP, with a stronger effect on ETP in PRP (PRP, β:76.7 [47.5; 106]; PFP, β:34.8 [10.3; 59.2]). After adjustment for fibrinogen, the relation between CRP and ETP was attenuated in PRP and PFP. Of the traditional cardiovascular risk factors (CVRFs), obesity was positively associated to TG in PRP only. Our findings support that TG, particularly in PRP, relates to traditional CVRFs in a representative sample from a population-based study. Assessment of procoagulant activity in a platelet-dependent manner by TG is a promising tool for assessing individual risk for CVD.

AB - The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might be an important indicator of prothrombotic risk linked to cardiovascular disease (CVD), but the presence of platelets may be a critical determinant. Clinical data, laboratory markers and thrombin generation (TG), investigated in both platelet-rich plasma (PRP) and platelet-free plasma (PFP) at 1 pM TF, were available in 407 individuals from the Gutenberg Health Study. Given the well-known effect of anticoagulants on TG, subjects taking anticoagulants (n = 15) have been excluded resulting in 392 subjects for further analysis. Lag time, endogenous thrombin potential (ETP) and peak height were the investigated parameters of a TG curve. Multivariable linear regression analysis was used to identify TG determinants. Mean platelet volume (MPV) and platelet count were both negatively associated to lag time and positively to peak height (MPV, β:6.35 [2.66; 10.0]; platelet count, β:0.111 [0.054; 0.169]) in PRP only. C-reactive protein was positively associated with lag time and ETP in both PRP and PFP, with a stronger effect on ETP in PRP (PRP, β:76.7 [47.5; 106]; PFP, β:34.8 [10.3; 59.2]). After adjustment for fibrinogen, the relation between CRP and ETP was attenuated in PRP and PFP. Of the traditional cardiovascular risk factors (CVRFs), obesity was positively associated to TG in PRP only. Our findings support that TG, particularly in PRP, relates to traditional CVRFs in a representative sample from a population-based study. Assessment of procoagulant activity in a platelet-dependent manner by TG is a promising tool for assessing individual risk for CVD.

KW - Adult

KW - Aged

KW - Blood Coagulation

KW - Blood Coagulation Tests

KW - Blood Platelets/enzymology

KW - C-Reactive Protein/metabolism

KW - Cardiovascular Diseases/blood

KW - Female

KW - Germany

KW - Humans

KW - Male

KW - Mean Platelet Volume

KW - Middle Aged

KW - Platelet Count

KW - Platelet-Rich Plasma/enzymology

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Thrombin/metabolism

KW - Time Factors

U2 - 10.1055/s-0038-1641565

DO - 10.1055/s-0038-1641565

M3 - SCORING: Journal article

C2 - 29614519

VL - 118

SP - 873

EP - 882

JO - THROMB HAEMOSTASIS

JF - THROMB HAEMOSTASIS

SN - 0340-6245

IS - 5

ER -