Clinical and Biological Characteristics of Medullary and Extramedullary Plasma Cell Dyscrasias
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Clinical and Biological Characteristics of Medullary and Extramedullary Plasma Cell Dyscrasias. / Janjetovic, Snjezana; Lohneis, Philipp; Nogai, Axel; Balci, Derya; Rasche, Leo; Jähne, Doris; Bokemeyer, Carsten; Schilling, Georgia; Blau, Igor Wolfgang; Schmidt-Hieber, Martin.
In: BIOLOGY-BASEL, Vol. 10, No. 7, 629, 06.07.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Clinical and Biological Characteristics of Medullary and Extramedullary Plasma Cell Dyscrasias
AU - Janjetovic, Snjezana
AU - Lohneis, Philipp
AU - Nogai, Axel
AU - Balci, Derya
AU - Rasche, Leo
AU - Jähne, Doris
AU - Bokemeyer, Carsten
AU - Schilling, Georgia
AU - Blau, Igor Wolfgang
AU - Schmidt-Hieber, Martin
PY - 2021/7/6
Y1 - 2021/7/6
N2 - Background: Extramedullary plasma cell (PC) disorders may occur as extramedullary disease in multiple myeloma (MM-EMD) or as primary extramedullary plasmocytoma (pEMP)/solitary osseous plasmocytoma (SOP). In this study, we aimed to obtain insights into the molecular mechanisms of extramedullary spread of clonal PC. Methods: Clinical and biological characteristics of 87 patients with MM-EMD (n = 49), pEMP/SOP (n = 20) and classical MM (n = 18) were analyzed by using immunohistochemistry (CXCR4, CD31, CD44 and CD81 staining) and cytoplasmic immunoglobulin staining combined with fluorescence in situ hybridization (cIg-FISH). Results: High expression of CD44, a cell-surface glycoprotein involved in cell-cell interactions, was significantly enriched in MM-EMD (90%) vs. pEMP/SOP (27%) or classical MM (33%) (p < 0.001). In addition, 1q21 amplification by clonal PC occurred at a similar frequency of MM-EMD (33%), pEMP/SOP (57%) and classical MM (44%). Conversely, del(17p13), t(4;14) and t(14;16) were completely absent in pEMP/SOP. Besides this, 1q21 amplification was identified in 64% of not paraskeletal samples from MM-EMD or pEMP compared to 9% of SOP or paraskeletal MM-EMD/pEMP and 44% of classical MM samples, respectively (p = 0.02). Conclusion: Expression of molecules involved in homing and cytogenetic aberrations differ between MM with or without EMD and pEMP/SOP.
AB - Background: Extramedullary plasma cell (PC) disorders may occur as extramedullary disease in multiple myeloma (MM-EMD) or as primary extramedullary plasmocytoma (pEMP)/solitary osseous plasmocytoma (SOP). In this study, we aimed to obtain insights into the molecular mechanisms of extramedullary spread of clonal PC. Methods: Clinical and biological characteristics of 87 patients with MM-EMD (n = 49), pEMP/SOP (n = 20) and classical MM (n = 18) were analyzed by using immunohistochemistry (CXCR4, CD31, CD44 and CD81 staining) and cytoplasmic immunoglobulin staining combined with fluorescence in situ hybridization (cIg-FISH). Results: High expression of CD44, a cell-surface glycoprotein involved in cell-cell interactions, was significantly enriched in MM-EMD (90%) vs. pEMP/SOP (27%) or classical MM (33%) (p < 0.001). In addition, 1q21 amplification by clonal PC occurred at a similar frequency of MM-EMD (33%), pEMP/SOP (57%) and classical MM (44%). Conversely, del(17p13), t(4;14) and t(14;16) were completely absent in pEMP/SOP. Besides this, 1q21 amplification was identified in 64% of not paraskeletal samples from MM-EMD or pEMP compared to 9% of SOP or paraskeletal MM-EMD/pEMP and 44% of classical MM samples, respectively (p = 0.02). Conclusion: Expression of molecules involved in homing and cytogenetic aberrations differ between MM with or without EMD and pEMP/SOP.
U2 - 10.3390/biology10070629
DO - 10.3390/biology10070629
M3 - SCORING: Journal article
C2 - 34356484
VL - 10
JO - BIOLOGY-BASEL
JF - BIOLOGY-BASEL
SN - 2079-7737
IS - 7
M1 - 629
ER -
