Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas

B Puig; A Tortosa; I Ferrer; Berta Puig Martorell

Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas

Standard

Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. / Puig, B; Tortosa, A; Ferrer, I; Puig Martorell, Berta.

In: NEUROSCI LETT, Vol. 306, No. 1-2, 22.06.2001, p. 85-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Puig, B, Tortosa, A, Ferrer, I & Puig Martorell, B 2001, 'Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas', NEUROSCI LETT, vol. 306, no. 1-2, pp. 85-8.

APA

Puig, B., Tortosa, A., Ferrer, I., & Puig Martorell, B. (2001). Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. NEUROSCI LETT, 306(1-2), 85-8.

Vancouver

Puig B, Tortosa A, Ferrer I, Puig Martorell B. Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas. NEUROSCI LETT. 2001 Jun 22;306(1-2):85-8.

Bibtex

@article{02af659f8b4249df97e2e9a0f9b3adb1,

title = "Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas",

abstract = "Expression of cleaved caspase-3, cleaved caspase-7 and specific product of caspase-dependent Poly (ADP-Ribose) Polymerase (PARP) cleavage have been examined by immunohistochemistry in seven human medulloblastomas. Cleaved caspase-3 and cleaved PARP expression parallels apoptosis as revealed with classical morphological criteria and with the method of in situ end-labelling of nuclear DNA fragmentation. Cleaved PARP co-localizes cleaved caspase-3 in the majority of tumors and areas thus indicating that caspase-3 is a major effector caspase leading to apoptosis in these tumors. Yet cleaved caspase-7 was also expressed in a small number of cells in four of seven tumors, but was the predominant caspase associated with cleaved PARP in one medulloblastoma. These findings indicate that effector caspase-3 and -7 may act in association, although caspase-7 may be exceptionally dominant in selected tumors.",

keywords = "Apoptosis, Caspase 3, Caspase 7, Caspases, Cerebellar Neoplasms, DNA Fragmentation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Medulloblastoma, Poly(ADP-ribose) Polymerases",

author = "B Puig and A Tortosa and I Ferrer and {Puig Martorell}, Berta",

year = "2001",

month = jun,

day = "22",

language = "English",

volume = "306",

pages = "85--8",

journal = "NEUROSCI LETT",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

RIS

TY - JOUR

T1 - Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas

AU - Puig, B

AU - Tortosa, A

AU - Ferrer, I

AU - Puig Martorell, Berta

PY - 2001/6/22

Y1 - 2001/6/22

N2 - Expression of cleaved caspase-3, cleaved caspase-7 and specific product of caspase-dependent Poly (ADP-Ribose) Polymerase (PARP) cleavage have been examined by immunohistochemistry in seven human medulloblastomas. Cleaved caspase-3 and cleaved PARP expression parallels apoptosis as revealed with classical morphological criteria and with the method of in situ end-labelling of nuclear DNA fragmentation. Cleaved PARP co-localizes cleaved caspase-3 in the majority of tumors and areas thus indicating that caspase-3 is a major effector caspase leading to apoptosis in these tumors. Yet cleaved caspase-7 was also expressed in a small number of cells in four of seven tumors, but was the predominant caspase associated with cleaved PARP in one medulloblastoma. These findings indicate that effector caspase-3 and -7 may act in association, although caspase-7 may be exceptionally dominant in selected tumors.

AB - Expression of cleaved caspase-3, cleaved caspase-7 and specific product of caspase-dependent Poly (ADP-Ribose) Polymerase (PARP) cleavage have been examined by immunohistochemistry in seven human medulloblastomas. Cleaved caspase-3 and cleaved PARP expression parallels apoptosis as revealed with classical morphological criteria and with the method of in situ end-labelling of nuclear DNA fragmentation. Cleaved PARP co-localizes cleaved caspase-3 in the majority of tumors and areas thus indicating that caspase-3 is a major effector caspase leading to apoptosis in these tumors. Yet cleaved caspase-7 was also expressed in a small number of cells in four of seven tumors, but was the predominant caspase associated with cleaved PARP in one medulloblastoma. These findings indicate that effector caspase-3 and -7 may act in association, although caspase-7 may be exceptionally dominant in selected tumors.

KW - Apoptosis

KW - Caspase 3

KW - Caspase 7

KW - Caspases

KW - Cerebellar Neoplasms

KW - DNA Fragmentation

KW - Gene Expression Regulation, Enzymologic

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - In Situ Nick-End Labeling

KW - Medulloblastoma

KW - Poly(ADP-ribose) Polymerases

M3 - SCORING: Journal article

C2 - 11403964

VL - 306

SP - 85

EP - 88

JO - NEUROSCI LETT

JF - NEUROSCI LETT

SN - 0304-3940

IS - 1-2

ER -