Classification of lesion area in stroke patients during the subacute Phase: a multiparametric MRI study
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Classification of lesion area in stroke patients during the subacute Phase: a multiparametric MRI study. / Artzi, Moran; Aizenstein, Orna; Jonas-Kimchi, Tali; Bornstein, Natan; Shopin, Ludmila; Hallevi, Hen; Ben Bashat, Dafna; STIR/VISTA Imaging Collaboration.
In: MAGN RESON MED, Vol. 72, No. 5, 01.11.2014, p. 1381-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Classification of lesion area in stroke patients during the subacute Phase: a multiparametric MRI study
AU - Artzi, Moran
AU - Aizenstein, Orna
AU - Jonas-Kimchi, Tali
AU - Bornstein, Natan
AU - Shopin, Ludmila
AU - Hallevi, Hen
AU - Ben Bashat, Dafna
AU - STIR/VISTA Imaging Collaboration
AU - Thomalla, Götz
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - PURPOSE: Stroke imaging studies during the acute phase are likely to precede several vascular brain mechanisms, which have an important role in patient outcome. The aim of this study was to identify within the lesion area during the subacute phase (≥1 day) reactive tissue, which may have the potential for recovery.METHODS: Twenty seven stroke patients from two cohorts were included. MRI performed during the subacute phase included conventional, perfusion and diffusion imaging. In cohort I, unsupervised multiparametric classification of the lesion area was performed. In cohort II threshold based classification was performed during the subacute phase, and radiological outcome was assessed at follow-up scan.RESULTS: Three tissue classes were identified in cohort I, referred to as irreversibly damaged, intermediary, and reactive tissue. Based on threshold values defined in cohort I, the reactive tissue was identified in 11/13 patients in cohort II, and showed tissue preservation/partial recovery in 9/11 patients at follow-up scan. The irreversibly damaged tissue was identified in 7/13 patients in cohort II, and predicted tissue necrosis in all cases.CONCLUSION: Identification of reactive tissue following stroke during the subacute phase can improve radiological assessment, contribute to the understanding of brain recovery processes and has implications for new therapeutic approaches.
AB - PURPOSE: Stroke imaging studies during the acute phase are likely to precede several vascular brain mechanisms, which have an important role in patient outcome. The aim of this study was to identify within the lesion area during the subacute phase (≥1 day) reactive tissue, which may have the potential for recovery.METHODS: Twenty seven stroke patients from two cohorts were included. MRI performed during the subacute phase included conventional, perfusion and diffusion imaging. In cohort I, unsupervised multiparametric classification of the lesion area was performed. In cohort II threshold based classification was performed during the subacute phase, and radiological outcome was assessed at follow-up scan.RESULTS: Three tissue classes were identified in cohort I, referred to as irreversibly damaged, intermediary, and reactive tissue. Based on threshold values defined in cohort I, the reactive tissue was identified in 11/13 patients in cohort II, and showed tissue preservation/partial recovery in 9/11 patients at follow-up scan. The irreversibly damaged tissue was identified in 7/13 patients in cohort II, and predicted tissue necrosis in all cases.CONCLUSION: Identification of reactive tissue following stroke during the subacute phase can improve radiological assessment, contribute to the understanding of brain recovery processes and has implications for new therapeutic approaches.
U2 - 10.1002/mrm.25031
DO - 10.1002/mrm.25031
M3 - SCORING: Journal article
C2 - 24243644
VL - 72
SP - 1381
EP - 1388
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 5
ER -