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CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission

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CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission. / Derben, Finn C; Engel, Bastian; Zachou, Kalliopi; Hartl, Johannes; Hartleben, Björn; Bantel, Heike; Schramm, Christoph; Dalekos, George N; Manns, Michael P; Jaeckel, Elmar; Taubert, Richard.

In: LIVER INT, Vol. 41, No. 1, 01.2021, p. 123-127.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Derben, FC, Engel, B, Zachou, K, Hartl, J, Hartleben, B, Bantel, H, Schramm, C, Dalekos, GN, Manns, MP, Jaeckel, E & Taubert, R 2021, 'CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission', LIVER INT, vol. 41, no. 1, pp. 123-127. https://doi.org/10.1111/liv.14699

APA

Derben, F. C., Engel, B., Zachou, K., Hartl, J., Hartleben, B., Bantel, H., Schramm, C., Dalekos, G. N., Manns, M. P., Jaeckel, E., & Taubert, R. (2021). CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission. LIVER INT, 41(1), 123-127. https://doi.org/10.1111/liv.14699

Vancouver

Derben FC, Engel B, Zachou K, Hartl J, Hartleben B, Bantel H et al. CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission. LIVER INT. 2021 Jan;41(1):123-127. https://doi.org/10.1111/liv.14699

Bibtex

@article{1e21e9a65bfa4bba96ad37ce91d3e8b7,
title = "CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission",
abstract = "Incomplete histological remission of autoimmune hepatitis (AIH) is associated with a reduced long-term survival and an increased relapse rate even during biochemical remission (BR). The aim of this international multicentre study was to explore the diagnostic fidelity of cytokeratin-18 cell death markers to noninvasively detect incomplete histological remission. Thereby, cytokeratin-18 cell death marker M65 but not ALT and immunoglobulins was significantly higher in patients with incomplete histological remission (mHAI ≥ 4) compared to those with mHAI ≤ 3. M65 levels > 305 U/L, identified in the training cohort, facilitated the noninvasive detection of incomplete histological remission with a sensitivity of 75% and negative predictive value of 86% in the validation cohort. While BR with M65 < 305 U/L suggested complete histological remission (86%), BR with M65 > 305 U/L reduced the rate of histological remission to 60%. In conclusion, M65 may help to better select patients for or to reduce surveillance liver biopsies in the future.",
author = "Derben, {Finn C} and Bastian Engel and Kalliopi Zachou and Johannes Hartl and Bj{\"o}rn Hartleben and Heike Bantel and Christoph Schramm and Dalekos, {George N} and Manns, {Michael P} and Elmar Jaeckel and Richard Taubert",
note = "{\textcopyright} 2020 The Authors. Liver International published by John Wiley & Sons Ltd.",
year = "2021",
month = jan,
doi = "10.1111/liv.14699",
language = "English",
volume = "41",
pages = "123--127",
journal = "LIVER INT",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - CK-18 cell death markers improve the prediction of histological remission in autoimmune hepatitis during biochemical remission

AU - Derben, Finn C

AU - Engel, Bastian

AU - Zachou, Kalliopi

AU - Hartl, Johannes

AU - Hartleben, Björn

AU - Bantel, Heike

AU - Schramm, Christoph

AU - Dalekos, George N

AU - Manns, Michael P

AU - Jaeckel, Elmar

AU - Taubert, Richard

N1 - © 2020 The Authors. Liver International published by John Wiley & Sons Ltd.

PY - 2021/1

Y1 - 2021/1

N2 - Incomplete histological remission of autoimmune hepatitis (AIH) is associated with a reduced long-term survival and an increased relapse rate even during biochemical remission (BR). The aim of this international multicentre study was to explore the diagnostic fidelity of cytokeratin-18 cell death markers to noninvasively detect incomplete histological remission. Thereby, cytokeratin-18 cell death marker M65 but not ALT and immunoglobulins was significantly higher in patients with incomplete histological remission (mHAI ≥ 4) compared to those with mHAI ≤ 3. M65 levels > 305 U/L, identified in the training cohort, facilitated the noninvasive detection of incomplete histological remission with a sensitivity of 75% and negative predictive value of 86% in the validation cohort. While BR with M65 < 305 U/L suggested complete histological remission (86%), BR with M65 > 305 U/L reduced the rate of histological remission to 60%. In conclusion, M65 may help to better select patients for or to reduce surveillance liver biopsies in the future.

AB - Incomplete histological remission of autoimmune hepatitis (AIH) is associated with a reduced long-term survival and an increased relapse rate even during biochemical remission (BR). The aim of this international multicentre study was to explore the diagnostic fidelity of cytokeratin-18 cell death markers to noninvasively detect incomplete histological remission. Thereby, cytokeratin-18 cell death marker M65 but not ALT and immunoglobulins was significantly higher in patients with incomplete histological remission (mHAI ≥ 4) compared to those with mHAI ≤ 3. M65 levels > 305 U/L, identified in the training cohort, facilitated the noninvasive detection of incomplete histological remission with a sensitivity of 75% and negative predictive value of 86% in the validation cohort. While BR with M65 < 305 U/L suggested complete histological remission (86%), BR with M65 > 305 U/L reduced the rate of histological remission to 60%. In conclusion, M65 may help to better select patients for or to reduce surveillance liver biopsies in the future.

U2 - 10.1111/liv.14699

DO - 10.1111/liv.14699

M3 - SCORING: Journal article

C2 - 33043565

VL - 41

SP - 123

EP - 127

JO - LIVER INT

JF - LIVER INT

SN - 1478-3223

IS - 1

ER -