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Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers

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Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers. / Lindner, Kirsten; Haier, Joerg; Wang, Zhe; Watson, David I; Hussey, Damian J; Hummel, Richard.

In: CLIN SCI, Vol. 128, No. 1, 01.2015, p. 1-15.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lindner, K, Haier, J, Wang, Z, Watson, DI, Hussey, DJ & Hummel, R 2015, 'Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers', CLIN SCI, vol. 128, no. 1, pp. 1-15. https://doi.org/10.1042/CS20140089

APA

Lindner, K., Haier, J., Wang, Z., Watson, D. I., Hussey, D. J., & Hummel, R. (2015). Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers. CLIN SCI, 128(1), 1-15. https://doi.org/10.1042/CS20140089

Vancouver

Lindner K, Haier J, Wang Z, Watson DI, Hussey DJ, Hummel R. Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers. CLIN SCI. 2015 Jan;128(1):1-15. https://doi.org/10.1042/CS20140089

Bibtex

@article{be21d7f297d54ab4879158c7989dd6ba,
title = "Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers",
abstract = "To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumour and therefore might correlate with tumour progression and recurrence, and they are bound to proteins or contained in subcellular particles, such as microvesicles or exosomes, making them highly stable and resistant to degradation. The present review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications of circulating miRNAs for diagnostic and prognostic purposes.",
keywords = "Biomarkers, Gastrointestinal Neoplasms, Humans, MicroRNAs, Prognosis",
author = "Kirsten Lindner and Joerg Haier and Zhe Wang and Watson, {David I} and Hussey, {Damian J} and Richard Hummel",
year = "2015",
month = jan,
doi = "10.1042/CS20140089",
language = "English",
volume = "128",
pages = "1--15",
journal = "CLIN SCI",
issn = "0143-5221",
publisher = "PORTLAND PRESS LTD",
number = "1",

}

RIS

TY - JOUR

T1 - Circulating microRNAs emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers

AU - Lindner, Kirsten

AU - Haier, Joerg

AU - Wang, Zhe

AU - Watson, David I

AU - Hussey, Damian J

AU - Hummel, Richard

PY - 2015/1

Y1 - 2015/1

N2 - To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumour and therefore might correlate with tumour progression and recurrence, and they are bound to proteins or contained in subcellular particles, such as microvesicles or exosomes, making them highly stable and resistant to degradation. The present review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications of circulating miRNAs for diagnostic and prognostic purposes.

AB - To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumour and therefore might correlate with tumour progression and recurrence, and they are bound to proteins or contained in subcellular particles, such as microvesicles or exosomes, making them highly stable and resistant to degradation. The present review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications of circulating miRNAs for diagnostic and prognostic purposes.

KW - Biomarkers

KW - Gastrointestinal Neoplasms

KW - Humans

KW - MicroRNAs

KW - Prognosis

U2 - 10.1042/CS20140089

DO - 10.1042/CS20140089

M3 - SCORING: Journal article

C2 - 25168167

VL - 128

SP - 1

EP - 15

JO - CLIN SCI

JF - CLIN SCI

SN - 0143-5221

IS - 1

ER -