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Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism

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Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. / Jiménez-Alcázar, Miguel; Limacher, Andreas; Panda, Rachita; Méan, Marie; Bitterling, Josephine; Peine, Sven; Renné, Thomas; Beer, Jürg H; Aujesky, Drahomir; Lämmle, Bernhard; Fuchs, Tobias A.

In: PLOS ONE, Vol. 13, No. 2, 2018, p. e0191150.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jiménez-Alcázar, M, Limacher, A, Panda, R, Méan, M, Bitterling, J, Peine, S, Renné, T, Beer, JH, Aujesky, D, Lämmle, B & Fuchs, TA 2018, 'Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism', PLOS ONE, vol. 13, no. 2, pp. e0191150. https://doi.org/10.1371/journal.pone.0191150

APA

Jiménez-Alcázar, M., Limacher, A., Panda, R., Méan, M., Bitterling, J., Peine, S., Renné, T., Beer, J. H., Aujesky, D., Lämmle, B., & Fuchs, T. A. (2018). Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. PLOS ONE, 13(2), e0191150. https://doi.org/10.1371/journal.pone.0191150

Vancouver

Jiménez-Alcázar M, Limacher A, Panda R, Méan M, Bitterling J, Peine S et al. Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. PLOS ONE. 2018;13(2):e0191150. https://doi.org/10.1371/journal.pone.0191150

Bibtex

@article{6b43df9ae2474ceea1d967cae7151317,
title = "Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism",
abstract = "BACKGROUND: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.OBJECTIVES: We analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.METHODS: We quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute VTE of a prospective cohort study (SWITCO65+).RESULTS: Levels of ceDNA and nucleosomes, but not NETs, correlated with VTE extent. Infectious comorbidities independently increased ceDNA levels in VTE. CeDNA strongly correlated with C-reactive protein and leukocytosis, suggesting an association of ceDNA with inflammation in VTE patients. CeDNA furthermore predicted PE-related and all-cause mortality, but not VTE recurrence, during a 3-year follow-up.CONCLUSIONS: Our study suggests that ceDNA levels in VTE patients reflect the degree of inflammation and may serve as a biomarker to stratify VTE patients at risk for mortality.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Miguel Jim{\'e}nez-Alc{\'a}zar and Andreas Limacher and Rachita Panda and Marie M{\'e}an and Josephine Bitterling and Sven Peine and Thomas Renn{\'e} and Beer, {J{\"u}rg H} and Drahomir Aujesky and Bernhard L{\"a}mmle and Fuchs, {Tobias A}",
year = "2018",
doi = "10.1371/journal.pone.0191150",
language = "English",
volume = "13",
pages = "e0191150",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism

AU - Jiménez-Alcázar, Miguel

AU - Limacher, Andreas

AU - Panda, Rachita

AU - Méan, Marie

AU - Bitterling, Josephine

AU - Peine, Sven

AU - Renné, Thomas

AU - Beer, Jürg H

AU - Aujesky, Drahomir

AU - Lämmle, Bernhard

AU - Fuchs, Tobias A

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.OBJECTIVES: We analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.METHODS: We quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute VTE of a prospective cohort study (SWITCO65+).RESULTS: Levels of ceDNA and nucleosomes, but not NETs, correlated with VTE extent. Infectious comorbidities independently increased ceDNA levels in VTE. CeDNA strongly correlated with C-reactive protein and leukocytosis, suggesting an association of ceDNA with inflammation in VTE patients. CeDNA furthermore predicted PE-related and all-cause mortality, but not VTE recurrence, during a 3-year follow-up.CONCLUSIONS: Our study suggests that ceDNA levels in VTE patients reflect the degree of inflammation and may serve as a biomarker to stratify VTE patients at risk for mortality.

AB - BACKGROUND: Venous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.OBJECTIVES: We analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.METHODS: We quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute VTE of a prospective cohort study (SWITCO65+).RESULTS: Levels of ceDNA and nucleosomes, but not NETs, correlated with VTE extent. Infectious comorbidities independently increased ceDNA levels in VTE. CeDNA strongly correlated with C-reactive protein and leukocytosis, suggesting an association of ceDNA with inflammation in VTE patients. CeDNA furthermore predicted PE-related and all-cause mortality, but not VTE recurrence, during a 3-year follow-up.CONCLUSIONS: Our study suggests that ceDNA levels in VTE patients reflect the degree of inflammation and may serve as a biomarker to stratify VTE patients at risk for mortality.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0191150

DO - 10.1371/journal.pone.0191150

M3 - SCORING: Journal article

C2 - 29474368

VL - 13

SP - e0191150

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

ER -