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Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men

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Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. / Agorastos, Agorastos; Hauger, Richard L; Barkauskas, Donald A; Moeller-Bertram, Tobias; Clopton, Paul L; Haji, Uzair; Lohr, James B; Geracioti, Thomas D; Patel, Piyush M; Chrousos, George P; Baker, Dewleen G.

In: PSYCHONEUROENDOCRINO, Vol. 44, 01.06.2014, p. 71-82.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Agorastos, A, Hauger, RL, Barkauskas, DA, Moeller-Bertram, T, Clopton, PL, Haji, U, Lohr, JB, Geracioti, TD, Patel, PM, Chrousos, GP & Baker, DG 2014, 'Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men', PSYCHONEUROENDOCRINO, vol. 44, pp. 71-82. https://doi.org/10.1016/j.psyneuen.2014.02.020

APA

Agorastos, A., Hauger, R. L., Barkauskas, D. A., Moeller-Bertram, T., Clopton, P. L., Haji, U., Lohr, J. B., Geracioti, T. D., Patel, P. M., Chrousos, G. P., & Baker, D. G. (2014). Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. PSYCHONEUROENDOCRINO, 44, 71-82. https://doi.org/10.1016/j.psyneuen.2014.02.020

Vancouver

Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U et al. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. PSYCHONEUROENDOCRINO. 2014 Jun 1;44:71-82. https://doi.org/10.1016/j.psyneuen.2014.02.020

Bibtex

@article{2b3a35f3fc8e47c7a86c33af5b8e2ea9,
title = "Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men",
abstract = "BACKGROUND: Interleukin-6 (IL-6) is a cytokine with pleiotropic actions in both the periphery of the body and the central nervous system (CNS). Altered IL-6 secretion has been associated with inflammatory dysregulation and several adverse health consequences. However, little is known about the physiological circadian characteristics and dynamic inter-correlation between circulating and CNS IL-6 levels in humans, or their significance.METHODS: Simultaneous assessment of plasma and cerebrospinal fluid (CSF) IL-6 levels was performed hourly in 11 healthy male volunteers over 24h, to characterize physiological IL-6 secretion levels in both compartments.RESULTS: IL-6 levels showed considerable within- and between-subject variability in both plasma and CSF, with plasma/CSF ratios revealing consistently higher levels in the CSF. Both CSF and plasma IL-6 levels showed a distinctive circadian variation, with CSF IL-6 levels exhibiting a main 24h, and plasma a biphasic 12h, circadian component. Plasma peaks were roughly at 4 p.m. and 4 a.m., while the CSF peak was at around 7 p.m. There was no correlation between coincident CSF and plasma IL-6 values, but evidence for significant correlations at a negative 7-8h time lag.CONCLUSIONS: This study provides evidence in humans for a circadian IL-6 rhythm in CSF and confirms prior observations reporting a plasma biphasic circadian pattern. Our results indicate differential IL-6 regulation across the two compartments and are consistent with local production of IL-6 in the CNS. Possible physiological significance is discussed and implications for further research are highlighted.",
author = "Agorastos Agorastos and Hauger, {Richard L} and Barkauskas, {Donald A} and Tobias Moeller-Bertram and Clopton, {Paul L} and Uzair Haji and Lohr, {James B} and Geracioti, {Thomas D} and Patel, {Piyush M} and Chrousos, {George P} and Baker, {Dewleen G}",
note = "Published by Elsevier Ltd.",
year = "2014",
month = jun,
day = "1",
doi = "10.1016/j.psyneuen.2014.02.020",
language = "English",
volume = "44",
pages = "71--82",
journal = "PSYCHONEUROENDOCRINO",
issn = "0306-4530",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men

AU - Agorastos, Agorastos

AU - Hauger, Richard L

AU - Barkauskas, Donald A

AU - Moeller-Bertram, Tobias

AU - Clopton, Paul L

AU - Haji, Uzair

AU - Lohr, James B

AU - Geracioti, Thomas D

AU - Patel, Piyush M

AU - Chrousos, George P

AU - Baker, Dewleen G

N1 - Published by Elsevier Ltd.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - BACKGROUND: Interleukin-6 (IL-6) is a cytokine with pleiotropic actions in both the periphery of the body and the central nervous system (CNS). Altered IL-6 secretion has been associated with inflammatory dysregulation and several adverse health consequences. However, little is known about the physiological circadian characteristics and dynamic inter-correlation between circulating and CNS IL-6 levels in humans, or their significance.METHODS: Simultaneous assessment of plasma and cerebrospinal fluid (CSF) IL-6 levels was performed hourly in 11 healthy male volunteers over 24h, to characterize physiological IL-6 secretion levels in both compartments.RESULTS: IL-6 levels showed considerable within- and between-subject variability in both plasma and CSF, with plasma/CSF ratios revealing consistently higher levels in the CSF. Both CSF and plasma IL-6 levels showed a distinctive circadian variation, with CSF IL-6 levels exhibiting a main 24h, and plasma a biphasic 12h, circadian component. Plasma peaks were roughly at 4 p.m. and 4 a.m., while the CSF peak was at around 7 p.m. There was no correlation between coincident CSF and plasma IL-6 values, but evidence for significant correlations at a negative 7-8h time lag.CONCLUSIONS: This study provides evidence in humans for a circadian IL-6 rhythm in CSF and confirms prior observations reporting a plasma biphasic circadian pattern. Our results indicate differential IL-6 regulation across the two compartments and are consistent with local production of IL-6 in the CNS. Possible physiological significance is discussed and implications for further research are highlighted.

AB - BACKGROUND: Interleukin-6 (IL-6) is a cytokine with pleiotropic actions in both the periphery of the body and the central nervous system (CNS). Altered IL-6 secretion has been associated with inflammatory dysregulation and several adverse health consequences. However, little is known about the physiological circadian characteristics and dynamic inter-correlation between circulating and CNS IL-6 levels in humans, or their significance.METHODS: Simultaneous assessment of plasma and cerebrospinal fluid (CSF) IL-6 levels was performed hourly in 11 healthy male volunteers over 24h, to characterize physiological IL-6 secretion levels in both compartments.RESULTS: IL-6 levels showed considerable within- and between-subject variability in both plasma and CSF, with plasma/CSF ratios revealing consistently higher levels in the CSF. Both CSF and plasma IL-6 levels showed a distinctive circadian variation, with CSF IL-6 levels exhibiting a main 24h, and plasma a biphasic 12h, circadian component. Plasma peaks were roughly at 4 p.m. and 4 a.m., while the CSF peak was at around 7 p.m. There was no correlation between coincident CSF and plasma IL-6 values, but evidence for significant correlations at a negative 7-8h time lag.CONCLUSIONS: This study provides evidence in humans for a circadian IL-6 rhythm in CSF and confirms prior observations reporting a plasma biphasic circadian pattern. Our results indicate differential IL-6 regulation across the two compartments and are consistent with local production of IL-6 in the CNS. Possible physiological significance is discussed and implications for further research are highlighted.

U2 - 10.1016/j.psyneuen.2014.02.020

DO - 10.1016/j.psyneuen.2014.02.020

M3 - SCORING: Journal article

C2 - 24767621

VL - 44

SP - 71

EP - 82

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

ER -