Research ExplorerPublicationsChronic parotitis: not another SPINKosis.

Chronic parotitis: not another SPINKosis.

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Chronic parotitis: not another SPINKosis. / Gundling, Felix; Reitmeier, Fabian; Tannapfel, Andrea; Schutz, Alexander; Weber, Anette; Ussmuller, Jurgen; Keim, Volker; Mossner, Joachim; Teich, Niels.

In: DIGEST DIS, Vol. 22, No. 3, 3, 2004, p. 292-295.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gundling, F, Reitmeier, F, Tannapfel, A, Schutz, A, Weber, A, Ussmuller, J, Keim, V, Mossner, J & Teich, N 2004, 'Chronic parotitis: not another SPINKosis.', DIGEST DIS, vol. 22, no. 3, 3, pp. 292-295. <http://www.ncbi.nlm.nih.gov/pubmed/15753612?dopt=Citation>

APA

Gundling, F., Reitmeier, F., Tannapfel, A., Schutz, A., Weber, A., Ussmuller, J., Keim, V., Mossner, J., & Teich, N. (2004). Chronic parotitis: not another SPINKosis. DIGEST DIS, 22(3), 292-295. [3]. http://www.ncbi.nlm.nih.gov/pubmed/15753612?dopt=Citation

Vancouver

Gundling F, Reitmeier F, Tannapfel A, Schutz A, Weber A, Ussmuller J et al. Chronic parotitis: not another SPINKosis. DIGEST DIS. 2004;22(3):292-295. 3.

Bibtex

@article{21aa5a6eafb14d769a616df484447cec,
title = "Chronic parotitis: not another SPINKosis.",
abstract = "INTRODUCTION: Pancreatitis and parotitis share several etiological, pathohistological and functional similarities. It arose from recent pancreatitis research that some cases of chronic pancreatitis are associated with mutations of the serine protease inhibitor, Kazal type-1 (SPINK1). We tested the hypothesis that the pancreatitis-associated N34S mutation of SPINK1 is also a risk factor for chronic parotitis. METHODS: Reverse-transcriptase polymerase chain reaction was used to investigate SPINK1 transcription in the parotid gland. Forty-five blocks of formalin-fixed, paraffin wax-embedded tissues with chronic parotitis of unknown cause were analyzed for the SPINK1-N34S mutation. RESULTS: The SPINK1 gene is transcribed in the parotid gland. Two of the 45 patients (4.4%) with chronic parotitis carried the N34S mutation heterozygously. Of 82 healthy blood donors, 3 subjects (3.7%) were identified as carrying this mutation heterozygously (p = 0.83). CONCLUSION: The SPINK1-N34S mutation is not associated with chronic parotitis.",
author = "Felix Gundling and Fabian Reitmeier and Andrea Tannapfel and Alexander Schutz and Anette Weber and Jurgen Ussmuller and Volker Keim and Joachim Mossner and Niels Teich",
year = "2004",
language = "Deutsch",
volume = "22",
pages = "292--295",
journal = "DIGEST DIS",
issn = "0257-2753",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Chronic parotitis: not another SPINKosis.

AU - Gundling, Felix

AU - Reitmeier, Fabian

AU - Tannapfel, Andrea

AU - Schutz, Alexander

AU - Weber, Anette

AU - Ussmuller, Jurgen

AU - Keim, Volker

AU - Mossner, Joachim

AU - Teich, Niels

PY - 2004

Y1 - 2004

N2 - INTRODUCTION: Pancreatitis and parotitis share several etiological, pathohistological and functional similarities. It arose from recent pancreatitis research that some cases of chronic pancreatitis are associated with mutations of the serine protease inhibitor, Kazal type-1 (SPINK1). We tested the hypothesis that the pancreatitis-associated N34S mutation of SPINK1 is also a risk factor for chronic parotitis. METHODS: Reverse-transcriptase polymerase chain reaction was used to investigate SPINK1 transcription in the parotid gland. Forty-five blocks of formalin-fixed, paraffin wax-embedded tissues with chronic parotitis of unknown cause were analyzed for the SPINK1-N34S mutation. RESULTS: The SPINK1 gene is transcribed in the parotid gland. Two of the 45 patients (4.4%) with chronic parotitis carried the N34S mutation heterozygously. Of 82 healthy blood donors, 3 subjects (3.7%) were identified as carrying this mutation heterozygously (p = 0.83). CONCLUSION: The SPINK1-N34S mutation is not associated with chronic parotitis.

AB - INTRODUCTION: Pancreatitis and parotitis share several etiological, pathohistological and functional similarities. It arose from recent pancreatitis research that some cases of chronic pancreatitis are associated with mutations of the serine protease inhibitor, Kazal type-1 (SPINK1). We tested the hypothesis that the pancreatitis-associated N34S mutation of SPINK1 is also a risk factor for chronic parotitis. METHODS: Reverse-transcriptase polymerase chain reaction was used to investigate SPINK1 transcription in the parotid gland. Forty-five blocks of formalin-fixed, paraffin wax-embedded tissues with chronic parotitis of unknown cause were analyzed for the SPINK1-N34S mutation. RESULTS: The SPINK1 gene is transcribed in the parotid gland. Two of the 45 patients (4.4%) with chronic parotitis carried the N34S mutation heterozygously. Of 82 healthy blood donors, 3 subjects (3.7%) were identified as carrying this mutation heterozygously (p = 0.83). CONCLUSION: The SPINK1-N34S mutation is not associated with chronic parotitis.

M3 - SCORING: Zeitschriftenaufsatz

VL - 22

SP - 292

EP - 295

JO - DIGEST DIS

JF - DIGEST DIS

SN - 0257-2753

IS - 3

M1 - 3

ER -