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Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort

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Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort. / Hahad, Omar; Schmitt, Volker H; Arnold, Natalie; Keller, Karsten; Prochaska, Jürgen H; Wild, Philipp S; Schulz, Andreas; Lackner, Karl J; Pfeiffer, Norbert; Schmidtmann, Irene; Michal, Matthias; Schattenberg, Jörn M; Tüscher, Oliver; Daiber, Andreas; Münzel, Thomas.

In: CLIN RES CARDIOL, Vol. 112, No. 2, 02.2023, p. 270-284.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hahad, O, Schmitt, VH, Arnold, N, Keller, K, Prochaska, JH, Wild, PS, Schulz, A, Lackner, KJ, Pfeiffer, N, Schmidtmann, I, Michal, M, Schattenberg, JM, Tüscher, O, Daiber, A & Münzel, T 2023, 'Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort', CLIN RES CARDIOL, vol. 112, no. 2, pp. 270-284. https://doi.org/10.1007/s00392-022-02092-1

APA

Hahad, O., Schmitt, V. H., Arnold, N., Keller, K., Prochaska, J. H., Wild, P. S., Schulz, A., Lackner, K. J., Pfeiffer, N., Schmidtmann, I., Michal, M., Schattenberg, J. M., Tüscher, O., Daiber, A., & Münzel, T. (2023). Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort. CLIN RES CARDIOL, 112(2), 270-284. https://doi.org/10.1007/s00392-022-02092-1

Vancouver

Hahad O, Schmitt VH, Arnold N, Keller K, Prochaska JH, Wild PS et al. Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort. CLIN RES CARDIOL. 2023 Feb;112(2):270-284. https://doi.org/10.1007/s00392-022-02092-1

Bibtex

@article{b060149cede0468da5d2a199acec6b34,
title = "Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort",
abstract = "BACKGROUND: Cigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event in the development of atherosclerotic CVD, remain still elusive. Thus, this study sought out to investigate sex-specific associations between smoking and measures of arterial stiffness.METHODS AND RESULTS: Overall, 15,010 participants (7584 men and 7426 women aged 35-74 years) of the Gutenberg Health Study were examined at baseline during 2007-2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a standardized computer-assisted interview. Arterial stiffness and wave reflection were determined by stiffness index (SI) and augmentation index (AI). In the total sample, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Median cumulative smoking exposure was 22.0 pack-years in current male smokers and 16.0 in current female smokers. In general, multivariable linear regression models adjusted for a comprehensive set of confounders revealed that smoking status, pack-years of smoking, and years since quitting smoking were dose-dependently associated with markers of arterial stiffness. In sex-specific analyses, these associations were overall more pronounced in men and SI was stronger related to the male sex, whereas differences between men and women in the case of AI appeared to be less substantial.DISCUSSION: The present results indicate that chronic smoking is strongly and dose-dependently associated with increased arterial stiffness in a large population-based cohort regardless of sex but with a stronger association in men.",
author = "Omar Hahad and Schmitt, {Volker H} and Natalie Arnold and Karsten Keller and Prochaska, {J{\"u}rgen H} and Wild, {Philipp S} and Andreas Schulz and Lackner, {Karl J} and Norbert Pfeiffer and Irene Schmidtmann and Matthias Michal and Schattenberg, {J{\"o}rn M} and Oliver T{\"u}scher and Andreas Daiber and Thomas M{\"u}nzel",
note = "{\textcopyright} 2022. The Author(s).",
year = "2023",
month = feb,
doi = "10.1007/s00392-022-02092-1",
language = "English",
volume = "112",
pages = "270--284",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - Chronic cigarette smoking is associated with increased arterial stiffness in men and women: evidence from a large population-based cohort

AU - Hahad, Omar

AU - Schmitt, Volker H

AU - Arnold, Natalie

AU - Keller, Karsten

AU - Prochaska, Jürgen H

AU - Wild, Philipp S

AU - Schulz, Andreas

AU - Lackner, Karl J

AU - Pfeiffer, Norbert

AU - Schmidtmann, Irene

AU - Michal, Matthias

AU - Schattenberg, Jörn M

AU - Tüscher, Oliver

AU - Daiber, Andreas

AU - Münzel, Thomas

N1 - © 2022. The Author(s).

PY - 2023/2

Y1 - 2023/2

N2 - BACKGROUND: Cigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event in the development of atherosclerotic CVD, remain still elusive. Thus, this study sought out to investigate sex-specific associations between smoking and measures of arterial stiffness.METHODS AND RESULTS: Overall, 15,010 participants (7584 men and 7426 women aged 35-74 years) of the Gutenberg Health Study were examined at baseline during 2007-2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a standardized computer-assisted interview. Arterial stiffness and wave reflection were determined by stiffness index (SI) and augmentation index (AI). In the total sample, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Median cumulative smoking exposure was 22.0 pack-years in current male smokers and 16.0 in current female smokers. In general, multivariable linear regression models adjusted for a comprehensive set of confounders revealed that smoking status, pack-years of smoking, and years since quitting smoking were dose-dependently associated with markers of arterial stiffness. In sex-specific analyses, these associations were overall more pronounced in men and SI was stronger related to the male sex, whereas differences between men and women in the case of AI appeared to be less substantial.DISCUSSION: The present results indicate that chronic smoking is strongly and dose-dependently associated with increased arterial stiffness in a large population-based cohort regardless of sex but with a stronger association in men.

AB - BACKGROUND: Cigarette smoking is a threat to global human health and a leading cause of the cardiovascular disease (CVD) morbidity and mortality. Importantly, sex-specific differences in smoking-induced arterial stiffness, an early key event in the development of atherosclerotic CVD, remain still elusive. Thus, this study sought out to investigate sex-specific associations between smoking and measures of arterial stiffness.METHODS AND RESULTS: Overall, 15,010 participants (7584 men and 7426 women aged 35-74 years) of the Gutenberg Health Study were examined at baseline during 2007-2012. Smoking status, pack-years of smoking, and years since quitting smoking were assessed by a standardized computer-assisted interview. Arterial stiffness and wave reflection were determined by stiffness index (SI) and augmentation index (AI). In the total sample, 45.8% had never smoked, 34.7% were former smokers, and 19.4% were current smokers. Median cumulative smoking exposure was 22.0 pack-years in current male smokers and 16.0 in current female smokers. In general, multivariable linear regression models adjusted for a comprehensive set of confounders revealed that smoking status, pack-years of smoking, and years since quitting smoking were dose-dependently associated with markers of arterial stiffness. In sex-specific analyses, these associations were overall more pronounced in men and SI was stronger related to the male sex, whereas differences between men and women in the case of AI appeared to be less substantial.DISCUSSION: The present results indicate that chronic smoking is strongly and dose-dependently associated with increased arterial stiffness in a large population-based cohort regardless of sex but with a stronger association in men.

U2 - 10.1007/s00392-022-02092-1

DO - 10.1007/s00392-022-02092-1

M3 - SCORING: Journal article

C2 - 36068365

VL - 112

SP - 270

EP - 284

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 2

ER -