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Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes.

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Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes. / Doege, Corinna; Koch, Martina; Heratizadeh, Annice; Sótonyi, Peter; Mengel, Michael; Nashan, Björn.

In: TRANSPL INT, Vol. 18, No. 8, 8, 2005, p. 981-991.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Doege, C, Koch, M, Heratizadeh, A, Sótonyi, P, Mengel, M & Nashan, B 2005, 'Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes.', TRANSPL INT, vol. 18, no. 8, 8, pp. 981-991. <http://www.ncbi.nlm.nih.gov/pubmed/16008750?dopt=Citation>

APA

Doege, C., Koch, M., Heratizadeh, A., Sótonyi, P., Mengel, M., & Nashan, B. (2005). Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes. TRANSPL INT, 18(8), 981-991. [8]. http://www.ncbi.nlm.nih.gov/pubmed/16008750?dopt=Citation

Vancouver

Doege C, Koch M, Heratizadeh A, Sótonyi P, Mengel M, Nashan B. Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes. TRANSPL INT. 2005;18(8):981-991. 8.

Bibtex

@article{1925ca6149874e5596b0e1a095b61c50,
title = "Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes.",
abstract = "The impact of presensitized T lymphocytes on the development of chronic allograft nephropathy (CAN) was investigated in nude athymic LEW.RNU recipients of F344 renal allografts. The recipients (n = 8) were reconstituted with 5 x 10(7) T lymphocytes primed against donor skin grafts to induce graft rejection. LEW.RNU (n = 8) and euthymic LEW recipients (n = 6) which underwent no further intervention after transplantation served as control groups. Adoptive transfer of primed T cells induced CAN in LEW.RNU rats. Their kidney function decreased progressively. After 90 days a moderate glomerulopathy, tubular atrophy and interstitial fibrosis were observed, vascular changes were only mild or absent. Cellular infiltrates were predominated by CD4+ T cells and ED1+ macrophages. Deposition of tenascin and laminin was enhanced. Grafts of euthymic recipients displayed only mild signs of CAN according to the Banff criteria. These data implicate an important role for the cellular immune response in the development of CAN.",
author = "Corinna Doege and Martina Koch and Annice Heratizadeh and Peter S{\'o}tonyi and Michael Mengel and Bj{\"o}rn Nashan",
year = "2005",
language = "Deutsch",
volume = "18",
pages = "981--991",
journal = "TRANSPL INT",
issn = "0934-0874",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Chronic allograft nephropathy in athymic nude rats after adoptive transfer of primed T lymphocytes.

AU - Doege, Corinna

AU - Koch, Martina

AU - Heratizadeh, Annice

AU - Sótonyi, Peter

AU - Mengel, Michael

AU - Nashan, Björn

PY - 2005

Y1 - 2005

N2 - The impact of presensitized T lymphocytes on the development of chronic allograft nephropathy (CAN) was investigated in nude athymic LEW.RNU recipients of F344 renal allografts. The recipients (n = 8) were reconstituted with 5 x 10(7) T lymphocytes primed against donor skin grafts to induce graft rejection. LEW.RNU (n = 8) and euthymic LEW recipients (n = 6) which underwent no further intervention after transplantation served as control groups. Adoptive transfer of primed T cells induced CAN in LEW.RNU rats. Their kidney function decreased progressively. After 90 days a moderate glomerulopathy, tubular atrophy and interstitial fibrosis were observed, vascular changes were only mild or absent. Cellular infiltrates were predominated by CD4+ T cells and ED1+ macrophages. Deposition of tenascin and laminin was enhanced. Grafts of euthymic recipients displayed only mild signs of CAN according to the Banff criteria. These data implicate an important role for the cellular immune response in the development of CAN.

AB - The impact of presensitized T lymphocytes on the development of chronic allograft nephropathy (CAN) was investigated in nude athymic LEW.RNU recipients of F344 renal allografts. The recipients (n = 8) were reconstituted with 5 x 10(7) T lymphocytes primed against donor skin grafts to induce graft rejection. LEW.RNU (n = 8) and euthymic LEW recipients (n = 6) which underwent no further intervention after transplantation served as control groups. Adoptive transfer of primed T cells induced CAN in LEW.RNU rats. Their kidney function decreased progressively. After 90 days a moderate glomerulopathy, tubular atrophy and interstitial fibrosis were observed, vascular changes were only mild or absent. Cellular infiltrates were predominated by CD4+ T cells and ED1+ macrophages. Deposition of tenascin and laminin was enhanced. Grafts of euthymic recipients displayed only mild signs of CAN according to the Banff criteria. These data implicate an important role for the cellular immune response in the development of CAN.

M3 - SCORING: Zeitschriftenaufsatz

VL - 18

SP - 981

EP - 991

JO - TRANSPL INT

JF - TRANSPL INT

SN - 0934-0874

IS - 8

M1 - 8

ER -