Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer.
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Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer. / El Gammal, Alexander Tarek; Brüchmann, Michael; Zustin, Jozef; Isbarn, Hendrik; Hellwinkel, Olaf; Köllermann, Jens; Sauter, Guido; Simon, Ronald; Wilczak, Waldemar; Schwarz, Jörg; Bokemeyer, Carsten; Brümmendorf, Tim; Izbicki, Jakob R.; Yekebas, Emre F.; Fisch, Margit; Huland, Hartwig; Graefen, Markus; Schlomm, Thorsten.
In: CLIN CANCER RES, Vol. 16, No. 1, 1, 2010, p. 56-64.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer.
AU - El Gammal, Alexander Tarek
AU - Brüchmann, Michael
AU - Zustin, Jozef
AU - Isbarn, Hendrik
AU - Hellwinkel, Olaf
AU - Köllermann, Jens
AU - Sauter, Guido
AU - Simon, Ronald
AU - Wilczak, Waldemar
AU - Schwarz, Jörg
AU - Bokemeyer, Carsten
AU - Brümmendorf, Tim
AU - Izbicki, Jakob R.
AU - Yekebas, Emre F.
AU - Fisch, Margit
AU - Huland, Hartwig
AU - Graefen, Markus
AU - Schlomm, Thorsten
PY - 2010
Y1 - 2010
N2 - PURPOSE: Deletions of 8p and gains of 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes of these alterations and their biological significance are unknown. EXPERIMENTAL DESIGN: To determine the relationship between chromosome 8 changes, and prostate cancer phenotype and prognosis, a set of 1.954 fully annotated prostate cancers were analyzed in a tissue microarray format by fluorescence in situ hybridization. RESULTS: Both 8p deletions and 8q gains increased in number during different stages of prostate cancer progression. 8p deletions/8q gains were found in 26.1%/4.8% of 1,239 pT(2) cancers, 38.5%/9.8% of 379 pT(3a) cancers, 43.5%/8.9% of 237 pT(3b) cancers, 40.7%/14.8% of 27 pT(4) cancers, 39.1%/34.8% of 23 nodal metastases, 51.9%/33.3% of 27 bone metastases, and 45.5%/59.9% of 22 hormone refractory cancers (P <0.0001 each). Both 8p deletions and 8q gains were also significantly associated with high Gleason grade and with each other (P <0.0001 each). In primary tumors, 8p deletions were seen in only 27.3% of 1,882 cancers without 8q gain but in 57.4% of 122 tumors with 8q gain (P <0.0001). Among cancers treated with radical prostatectomy, 8p deletions (P = 0.003) and 8q gains (P = 0.02) were associated with biochemical tumor recurrence. However, multivariate analysis (including prostate-specific antigen, pT/pN stage, Gleason score, and surgical margin status) did not reveal any statistically independent effect of 8p or 8q alterations on biochemical tumor recurrence. CONCLUSIONS: 8p deletions and 8q gains are relatively rare in early stage prostate cancer but often develop during tumor progression. The prognostic effect does not seem to be strong enough to warrant clinical application.
AB - PURPOSE: Deletions of 8p and gains of 8q belong to the most frequent cytogenetic alterations in prostate cancer. The target genes of these alterations and their biological significance are unknown. EXPERIMENTAL DESIGN: To determine the relationship between chromosome 8 changes, and prostate cancer phenotype and prognosis, a set of 1.954 fully annotated prostate cancers were analyzed in a tissue microarray format by fluorescence in situ hybridization. RESULTS: Both 8p deletions and 8q gains increased in number during different stages of prostate cancer progression. 8p deletions/8q gains were found in 26.1%/4.8% of 1,239 pT(2) cancers, 38.5%/9.8% of 379 pT(3a) cancers, 43.5%/8.9% of 237 pT(3b) cancers, 40.7%/14.8% of 27 pT(4) cancers, 39.1%/34.8% of 23 nodal metastases, 51.9%/33.3% of 27 bone metastases, and 45.5%/59.9% of 22 hormone refractory cancers (P <0.0001 each). Both 8p deletions and 8q gains were also significantly associated with high Gleason grade and with each other (P <0.0001 each). In primary tumors, 8p deletions were seen in only 27.3% of 1,882 cancers without 8q gain but in 57.4% of 122 tumors with 8q gain (P <0.0001). Among cancers treated with radical prostatectomy, 8p deletions (P = 0.003) and 8q gains (P = 0.02) were associated with biochemical tumor recurrence. However, multivariate analysis (including prostate-specific antigen, pT/pN stage, Gleason score, and surgical margin status) did not reveal any statistically independent effect of 8p or 8q alterations on biochemical tumor recurrence. CONCLUSIONS: 8p deletions and 8q gains are relatively rare in early stage prostate cancer but often develop during tumor progression. The prognostic effect does not seem to be strong enough to warrant clinical application.
M3 - SCORING: Journal article
VL - 16
SP - 56
EP - 64
JO - CLIN CANCER RES
JF - CLIN CANCER RES
SN - 1078-0432
IS - 1
M1 - 1
ER -
