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Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma

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Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. / Eichenauer, Till; Shadanpour, Navid; Kluth, Martina; Göbel, Cosima; Weidemann, Sören; Fraune, Christoph; Büscheck, Franziska; Hube-Magg, Claudia; Möller-Koop, Christina; Dahlem, Roland; Fisch, Margit; Rink, Michael; Riechardt, Silke; Burandt, Eike; Bernreuther, Christian; Minner, Sarah; Simon, Ronald; Sauter, Guido; Wilczak, Waldemar; Clauditz, Till.

In: WORLD J SURG ONCOL, Vol. 18, No. 1, 13.06.2020, p. 128.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eichenauer, T, Shadanpour, N, Kluth, M, Göbel, C, Weidemann, S, Fraune, C, Büscheck, F, Hube-Magg, C, Möller-Koop, C, Dahlem, R, Fisch, M, Rink, M, Riechardt, S, Burandt, E, Bernreuther, C, Minner, S, Simon, R, Sauter, G, Wilczak, W & Clauditz, T 2020, 'Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma', WORLD J SURG ONCOL, vol. 18, no. 1, pp. 128. https://doi.org/10.1186/s12957-020-01902-y

APA

Eichenauer, T., Shadanpour, N., Kluth, M., Göbel, C., Weidemann, S., Fraune, C., Büscheck, F., Hube-Magg, C., Möller-Koop, C., Dahlem, R., Fisch, M., Rink, M., Riechardt, S., Burandt, E., Bernreuther, C., Minner, S., Simon, R., Sauter, G., Wilczak, W., & Clauditz, T. (2020). Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. WORLD J SURG ONCOL, 18(1), 128. https://doi.org/10.1186/s12957-020-01902-y

Vancouver

Eichenauer T, Shadanpour N, Kluth M, Göbel C, Weidemann S, Fraune C et al. Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma. WORLD J SURG ONCOL. 2020 Jun 13;18(1):128. https://doi.org/10.1186/s12957-020-01902-y

Bibtex

@article{96d845eae40b40448e408af3a2bd544b,
title = "Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma",
abstract = "BACKGROUND: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain.METHODS: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes.RESULTS: A 17p13 deletion was found in 72 of 1429 interpretable tumors. The frequency of 17p13 deletions varied greatly between RCC subtypes and was highest in chromophobe RCC (24/72; 33.3%). 17p13 deletions were also found in 35 (3.7%) of 946 clear cell RCC, 9 (4.3%) of 208 papillary RCC, 1 of 121 oncocytomas (0.8%), as well as in several rare cases of comprising 1 of 7 Xp11.2 translocation cancers, 1 of 3 collecting duct carcinomas, and 1 of 20 not otherwise specified (NOS) carcinomas. In clear cell carcinomas, 17p13 deletions revealed a strong and consistent association with higher Fuhrman, ISUP, and Thoenes grade (p < 0.0001 each), and linked to advanced tumor stage (p = 0.0168), large tumor diameter (p = 0.0004), distant metastases (p = 0.0077), cancer-specific survival (p = 0.0391), and recurrence-free survival (p = 0.0072). In multivariate analysis, 17p13 deletions showed in clear cell RCC a dependent prognostic role for established clinical-pathological parameters.CONCLUSION: 17p13 deletions have a dual role in RCC. They are associated with disease progression in clear cell RCC and possibly other subtypes and they are linked to the development of chromophobe RCC-a subtype with a particularly favorable prognosis.",
author = "Till Eichenauer and Navid Shadanpour and Martina Kluth and Cosima G{\"o}bel and S{\"o}ren Weidemann and Christoph Fraune and Franziska B{\"u}scheck and Claudia Hube-Magg and Christina M{\"o}ller-Koop and Roland Dahlem and Margit Fisch and Michael Rink and Silke Riechardt and Eike Burandt and Christian Bernreuther and Sarah Minner and Ronald Simon and Guido Sauter and Waldemar Wilczak and Till Clauditz",
year = "2020",
month = jun,
day = "13",
doi = "10.1186/s12957-020-01902-y",
language = "English",
volume = "18",
pages = "128",
journal = "WORLD J SURG ONCOL",
issn = "1477-7819",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Chromosome 17p13 deletion is associated with an aggressive tumor phenotype in clear cell renal cell carcinoma

AU - Eichenauer, Till

AU - Shadanpour, Navid

AU - Kluth, Martina

AU - Göbel, Cosima

AU - Weidemann, Sören

AU - Fraune, Christoph

AU - Büscheck, Franziska

AU - Hube-Magg, Claudia

AU - Möller-Koop, Christina

AU - Dahlem, Roland

AU - Fisch, Margit

AU - Rink, Michael

AU - Riechardt, Silke

AU - Burandt, Eike

AU - Bernreuther, Christian

AU - Minner, Sarah

AU - Simon, Ronald

AU - Sauter, Guido

AU - Wilczak, Waldemar

AU - Clauditz, Till

PY - 2020/6/13

Y1 - 2020/6/13

N2 - BACKGROUND: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain.METHODS: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes.RESULTS: A 17p13 deletion was found in 72 of 1429 interpretable tumors. The frequency of 17p13 deletions varied greatly between RCC subtypes and was highest in chromophobe RCC (24/72; 33.3%). 17p13 deletions were also found in 35 (3.7%) of 946 clear cell RCC, 9 (4.3%) of 208 papillary RCC, 1 of 121 oncocytomas (0.8%), as well as in several rare cases of comprising 1 of 7 Xp11.2 translocation cancers, 1 of 3 collecting duct carcinomas, and 1 of 20 not otherwise specified (NOS) carcinomas. In clear cell carcinomas, 17p13 deletions revealed a strong and consistent association with higher Fuhrman, ISUP, and Thoenes grade (p < 0.0001 each), and linked to advanced tumor stage (p = 0.0168), large tumor diameter (p = 0.0004), distant metastases (p = 0.0077), cancer-specific survival (p = 0.0391), and recurrence-free survival (p = 0.0072). In multivariate analysis, 17p13 deletions showed in clear cell RCC a dependent prognostic role for established clinical-pathological parameters.CONCLUSION: 17p13 deletions have a dual role in RCC. They are associated with disease progression in clear cell RCC and possibly other subtypes and they are linked to the development of chromophobe RCC-a subtype with a particularly favorable prognosis.

AB - BACKGROUND: Deletions of 17p13 recurrently occur in renal cell carcinoma (RCC) but their prognostic role seems to be uncertain.METHODS: To determine prevalence, relationship with tumor phenotype, and patient prognosis, a tissue microarray containing samples from 1809 RCCs was evaluated using dual labeling fluorescence in situ hybridization (FISH) with 17p13 and chromosome 17 centromere probes.RESULTS: A 17p13 deletion was found in 72 of 1429 interpretable tumors. The frequency of 17p13 deletions varied greatly between RCC subtypes and was highest in chromophobe RCC (24/72; 33.3%). 17p13 deletions were also found in 35 (3.7%) of 946 clear cell RCC, 9 (4.3%) of 208 papillary RCC, 1 of 121 oncocytomas (0.8%), as well as in several rare cases of comprising 1 of 7 Xp11.2 translocation cancers, 1 of 3 collecting duct carcinomas, and 1 of 20 not otherwise specified (NOS) carcinomas. In clear cell carcinomas, 17p13 deletions revealed a strong and consistent association with higher Fuhrman, ISUP, and Thoenes grade (p < 0.0001 each), and linked to advanced tumor stage (p = 0.0168), large tumor diameter (p = 0.0004), distant metastases (p = 0.0077), cancer-specific survival (p = 0.0391), and recurrence-free survival (p = 0.0072). In multivariate analysis, 17p13 deletions showed in clear cell RCC a dependent prognostic role for established clinical-pathological parameters.CONCLUSION: 17p13 deletions have a dual role in RCC. They are associated with disease progression in clear cell RCC and possibly other subtypes and they are linked to the development of chromophobe RCC-a subtype with a particularly favorable prognosis.

U2 - 10.1186/s12957-020-01902-y

DO - 10.1186/s12957-020-01902-y

M3 - SCORING: Journal article

C2 - 32534597

VL - 18

SP - 128

JO - WORLD J SURG ONCOL

JF - WORLD J SURG ONCOL

SN - 1477-7819

IS - 1

ER -