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Chromatin dynamics in kidney development and function

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Chromatin dynamics in kidney development and function. / Bechtel-Walz, Wibke; Huber, Tobias B.

In: CELL TISSUE RES, Vol. 356, No. 3, 06.2014, p. 601-8.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Bechtel-Walz, W & Huber, TB 2014, 'Chromatin dynamics in kidney development and function', CELL TISSUE RES, vol. 356, no. 3, pp. 601-8. https://doi.org/10.1007/s00441-014-1884-y

APA

Bechtel-Walz, W., & Huber, T. B. (2014). Chromatin dynamics in kidney development and function. CELL TISSUE RES, 356(3), 601-8. https://doi.org/10.1007/s00441-014-1884-y

Vancouver

Bechtel-Walz W, Huber TB. Chromatin dynamics in kidney development and function. CELL TISSUE RES. 2014 Jun;356(3):601-8. https://doi.org/10.1007/s00441-014-1884-y

Bibtex

@article{82076e18cad64605a6e10d21a4c5029c,
title = "Chromatin dynamics in kidney development and function",
abstract = "Epigenetic mechanisms are fundamental key features of developing cells connecting developmental regulatory factors to chromatin modification. Changes in the environment during renal development can have long-lasting effects on the permanent tissue structure and the level of expression of important functional genes. These changes are believed to contribute to kidney disease occurrence and progression. Although the mechanisms of early patterning and cell fate have been well described for renal development, little is known about associated epigenetic modifications and their impact on how genes interact to specify the renal epithelial cells of nephrons and how this specification is relevant to maintaining normal renal function. A better understanding of the renal cell-specific epigenetic modifications and the interaction of different cell types to form this highly complex organ will not only help to better understand developmental defects and early loss of kidney function in children, but also help to understand and improve chronic disease progression, cell regeneration and renal aging.",
keywords = "Animals, Child, Preschool, Chromatin, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Humans, Kidney, Renal Insufficiency, Chronic, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Wibke Bechtel-Walz and Huber, {Tobias B}",
year = "2014",
month = jun,
doi = "10.1007/s00441-014-1884-y",
language = "English",
volume = "356",
pages = "601--8",
journal = "CELL TISSUE RES",
issn = "0302-766X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Chromatin dynamics in kidney development and function

AU - Bechtel-Walz, Wibke

AU - Huber, Tobias B

PY - 2014/6

Y1 - 2014/6

N2 - Epigenetic mechanisms are fundamental key features of developing cells connecting developmental regulatory factors to chromatin modification. Changes in the environment during renal development can have long-lasting effects on the permanent tissue structure and the level of expression of important functional genes. These changes are believed to contribute to kidney disease occurrence and progression. Although the mechanisms of early patterning and cell fate have been well described for renal development, little is known about associated epigenetic modifications and their impact on how genes interact to specify the renal epithelial cells of nephrons and how this specification is relevant to maintaining normal renal function. A better understanding of the renal cell-specific epigenetic modifications and the interaction of different cell types to form this highly complex organ will not only help to better understand developmental defects and early loss of kidney function in children, but also help to understand and improve chronic disease progression, cell regeneration and renal aging.

AB - Epigenetic mechanisms are fundamental key features of developing cells connecting developmental regulatory factors to chromatin modification. Changes in the environment during renal development can have long-lasting effects on the permanent tissue structure and the level of expression of important functional genes. These changes are believed to contribute to kidney disease occurrence and progression. Although the mechanisms of early patterning and cell fate have been well described for renal development, little is known about associated epigenetic modifications and their impact on how genes interact to specify the renal epithelial cells of nephrons and how this specification is relevant to maintaining normal renal function. A better understanding of the renal cell-specific epigenetic modifications and the interaction of different cell types to form this highly complex organ will not only help to better understand developmental defects and early loss of kidney function in children, but also help to understand and improve chronic disease progression, cell regeneration and renal aging.

KW - Animals

KW - Child, Preschool

KW - Chromatin

KW - Chromatin Assembly and Disassembly

KW - Epigenesis, Genetic

KW - Humans

KW - Kidney

KW - Renal Insufficiency, Chronic

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s00441-014-1884-y

DO - 10.1007/s00441-014-1884-y

M3 - SCORING: Review article

C2 - 24817101

VL - 356

SP - 601

EP - 608

JO - CELL TISSUE RES

JF - CELL TISSUE RES

SN - 0302-766X

IS - 3

ER -