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Childhood pineoblastoma

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Childhood pineoblastoma : experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. / Hinkes, Bernward G; von Hoff, Katja; Deinlein, Frank; Warmuth-Metz, Monika; Soerensen, Niels; Timmermann, Beate; Mittler, Uwe; Urban, Christian; Bode, Udo; Pietsch, Torsten; Schlegel, Paul G; Kortmann, Rolf D; Kuehl, Joachim; Rutkowski, Stefan.

In: J NEURO-ONCOL, Vol. 81, No. 2, 01.2007, p. 217-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hinkes, BG, von Hoff, K, Deinlein, F, Warmuth-Metz, M, Soerensen, N, Timmermann, B, Mittler, U, Urban, C, Bode, U, Pietsch, T, Schlegel, PG, Kortmann, RD, Kuehl, J & Rutkowski, S 2007, 'Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91', J NEURO-ONCOL, vol. 81, no. 2, pp. 217-23. https://doi.org/10.1007/s11060-006-9221-2

APA

Hinkes, B. G., von Hoff, K., Deinlein, F., Warmuth-Metz, M., Soerensen, N., Timmermann, B., Mittler, U., Urban, C., Bode, U., Pietsch, T., Schlegel, P. G., Kortmann, R. D., Kuehl, J., & Rutkowski, S. (2007). Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. J NEURO-ONCOL, 81(2), 217-23. https://doi.org/10.1007/s11060-006-9221-2

Vancouver

Hinkes BG, von Hoff K, Deinlein F, Warmuth-Metz M, Soerensen N, Timmermann B et al. Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. J NEURO-ONCOL. 2007 Jan;81(2):217-23. https://doi.org/10.1007/s11060-006-9221-2

Bibtex

@article{58e533f53de84808b20e72bb801a16ed,
title = "Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91",
abstract = "OBJECTIVE: To analyze the outcome of children with pineoblastoma (PB), treated within the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91 of German-speaking countries.PATIENTS: We report on 11 children suffering from PB. Five children younger than 3 years of age received chemotherapy after surgery until eligible for radiotherapy (HIT-SKK87 and HIT-SKK92). Five of six children older than 3 years were treated after surgery with immediate chemotherapy and craniospinal irradiation, and one child received maintenance chemotherapy after postoperative radiotherapy (HIT91).RESULTS: Five of the six older children are still alive in continuous complete remission (CCR) with a median overall survival (OS) and progression free survival (PFS) of 7.9 years. Five of these six HIT91 patients responded to postoperative chemotherapy and radiotherapy. The only patient with tumor progression during initial chemotherapy achieved complete remission with radiotherapy and is alive. In contrast, all five young children died of tumor progression after a median OS of 0.9 years (PFS 0.6 years). They had either metastatic disease (M1) and/or postoperative residual tumor. Response to postoperative chemotherapy was lower than in the older age group, and only one of these children received radiotherapy.CONCLUSIONS: Combined chemotherapy and radiotherapy were feasible and effective in the older age group, leading to prolonged remissions in five of six children. Tumor biology may be more aggressive in younger children with PB, who presented more frequently with high-risk features at diagnosis and had poorer response rates to neoadjuvant postoperative chemotherapy. More intensified treatment regimens may be needed for young children with PB.",
keywords = "Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Child, Child, Preschool, Combined Modality Therapy, Female, Humans, Male, Pineal Gland, Pinealoma, Prospective Studies, Treatment Outcome",
author = "Hinkes, {Bernward G} and {von Hoff}, Katja and Frank Deinlein and Monika Warmuth-Metz and Niels Soerensen and Beate Timmermann and Uwe Mittler and Christian Urban and Udo Bode and Torsten Pietsch and Schlegel, {Paul G} and Kortmann, {Rolf D} and Joachim Kuehl and Stefan Rutkowski",
year = "2007",
month = jan,
doi = "10.1007/s11060-006-9221-2",
language = "English",
volume = "81",
pages = "217--23",
journal = "J NEURO-ONCOL",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Childhood pineoblastoma

T2 - experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91

AU - Hinkes, Bernward G

AU - von Hoff, Katja

AU - Deinlein, Frank

AU - Warmuth-Metz, Monika

AU - Soerensen, Niels

AU - Timmermann, Beate

AU - Mittler, Uwe

AU - Urban, Christian

AU - Bode, Udo

AU - Pietsch, Torsten

AU - Schlegel, Paul G

AU - Kortmann, Rolf D

AU - Kuehl, Joachim

AU - Rutkowski, Stefan

PY - 2007/1

Y1 - 2007/1

N2 - OBJECTIVE: To analyze the outcome of children with pineoblastoma (PB), treated within the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91 of German-speaking countries.PATIENTS: We report on 11 children suffering from PB. Five children younger than 3 years of age received chemotherapy after surgery until eligible for radiotherapy (HIT-SKK87 and HIT-SKK92). Five of six children older than 3 years were treated after surgery with immediate chemotherapy and craniospinal irradiation, and one child received maintenance chemotherapy after postoperative radiotherapy (HIT91).RESULTS: Five of the six older children are still alive in continuous complete remission (CCR) with a median overall survival (OS) and progression free survival (PFS) of 7.9 years. Five of these six HIT91 patients responded to postoperative chemotherapy and radiotherapy. The only patient with tumor progression during initial chemotherapy achieved complete remission with radiotherapy and is alive. In contrast, all five young children died of tumor progression after a median OS of 0.9 years (PFS 0.6 years). They had either metastatic disease (M1) and/or postoperative residual tumor. Response to postoperative chemotherapy was lower than in the older age group, and only one of these children received radiotherapy.CONCLUSIONS: Combined chemotherapy and radiotherapy were feasible and effective in the older age group, leading to prolonged remissions in five of six children. Tumor biology may be more aggressive in younger children with PB, who presented more frequently with high-risk features at diagnosis and had poorer response rates to neoadjuvant postoperative chemotherapy. More intensified treatment regimens may be needed for young children with PB.

AB - OBJECTIVE: To analyze the outcome of children with pineoblastoma (PB), treated within the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91 of German-speaking countries.PATIENTS: We report on 11 children suffering from PB. Five children younger than 3 years of age received chemotherapy after surgery until eligible for radiotherapy (HIT-SKK87 and HIT-SKK92). Five of six children older than 3 years were treated after surgery with immediate chemotherapy and craniospinal irradiation, and one child received maintenance chemotherapy after postoperative radiotherapy (HIT91).RESULTS: Five of the six older children are still alive in continuous complete remission (CCR) with a median overall survival (OS) and progression free survival (PFS) of 7.9 years. Five of these six HIT91 patients responded to postoperative chemotherapy and radiotherapy. The only patient with tumor progression during initial chemotherapy achieved complete remission with radiotherapy and is alive. In contrast, all five young children died of tumor progression after a median OS of 0.9 years (PFS 0.6 years). They had either metastatic disease (M1) and/or postoperative residual tumor. Response to postoperative chemotherapy was lower than in the older age group, and only one of these children received radiotherapy.CONCLUSIONS: Combined chemotherapy and radiotherapy were feasible and effective in the older age group, leading to prolonged remissions in five of six children. Tumor biology may be more aggressive in younger children with PB, who presented more frequently with high-risk features at diagnosis and had poorer response rates to neoadjuvant postoperative chemotherapy. More intensified treatment regimens may be needed for young children with PB.

KW - Adolescent

KW - Adult

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Brain Neoplasms

KW - Child

KW - Child, Preschool

KW - Combined Modality Therapy

KW - Female

KW - Humans

KW - Male

KW - Pineal Gland

KW - Pinealoma

KW - Prospective Studies

KW - Treatment Outcome

U2 - 10.1007/s11060-006-9221-2

DO - 10.1007/s11060-006-9221-2

M3 - SCORING: Journal article

C2 - 16941074

VL - 81

SP - 217

EP - 223

JO - J NEURO-ONCOL

JF - J NEURO-ONCOL

SN - 0167-594X

IS - 2

ER -