Childhood medulloblastoma.
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Childhood medulloblastoma. / Massimino, Maura; Giangaspero, Felice; Garrè, Maria Luisa; Gandola, Lorenza; Poggi, Geraldina; Biassoni, Veronica; Gatta, Gemma; Rutkowski, Stefan.
In: CRIT REV ONCOL HEMAT, Vol. 79, No. 41, 41, 2011, p. 65-83.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Childhood medulloblastoma.
AU - Massimino, Maura
AU - Giangaspero, Felice
AU - Garrè, Maria Luisa
AU - Gandola, Lorenza
AU - Poggi, Geraldina
AU - Biassoni, Veronica
AU - Gatta, Gemma
AU - Rutkowski, Stefan
PY - 2011
Y1 - 2011
N2 - Among all the childhood central nervous system tumours, medulloblastoma and other neuroectodermal tumours account for 16-25% of cases. The causative factors of medulloblastoma/PNET have not been well established. It is more frequent in boys than in girl and in children than in adults. There was a significant improvement of survival for children diagnosed in 2000-2002 compared to those diagnosed in 1995-1999. The risk of dying was reduced by 30%. Patients are generally divided into risk-stratified schemes on the basis of age, the extent of residual disease, and dissemination. Sixty to 70% of patients older than 3 years are assigned to the average-risk group. High-risk patients include those in the disseminated category, and in North American trials those that have less than a gross or near-total resection, which is arbitrarily defined as 1.5cm(2) of post-operative residual disease. Current and currently planned clinical trials will:define molecular and biological markers that improve outcome prediction in patients with medulloblastoma and which can be incorporated for front-line stratification of newly defined risk subgroups.
AB - Among all the childhood central nervous system tumours, medulloblastoma and other neuroectodermal tumours account for 16-25% of cases. The causative factors of medulloblastoma/PNET have not been well established. It is more frequent in boys than in girl and in children than in adults. There was a significant improvement of survival for children diagnosed in 2000-2002 compared to those diagnosed in 1995-1999. The risk of dying was reduced by 30%. Patients are generally divided into risk-stratified schemes on the basis of age, the extent of residual disease, and dissemination. Sixty to 70% of patients older than 3 years are assigned to the average-risk group. High-risk patients include those in the disseminated category, and in North American trials those that have less than a gross or near-total resection, which is arbitrarily defined as 1.5cm(2) of post-operative residual disease. Current and currently planned clinical trials will:define molecular and biological markers that improve outcome prediction in patients with medulloblastoma and which can be incorporated for front-line stratification of newly defined risk subgroups.
M3 - SCORING: Zeitschriftenaufsatz
VL - 79
SP - 65
EP - 83
JO - CRIT REV ONCOL HEMAT
JF - CRIT REV ONCOL HEMAT
SN - 1040-8428
IS - 41
M1 - 41
ER -