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Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)

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Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). / Holz, Anja; Obi, Nadia; Ahrens, Wolfgang; Berger, Klaus; Bohn, Barbara; Brenner, Hermann; Fischer, Beate; Fricke, Julia; Führer, Amand; Gastell, Sylvia; Greiser, Karin Halina; Harth, Volker; Heise, Jana-Kristin; Holleczek, Bernd; Keil, Thomas; Klett-Tammen, Carolina J; Leitzmann, Michael; Lieb, Wolfgang; Meinke-Franze, Claudia; Michels, Karin B; Mikolajczyk, Rafael; Nimptsch, Katharina; Peters, Annette; Pischon, Tobias; Riedel, Oliver; Schikowski, Tamara; Schipf, Sabine; Schmidt, Börge; Schulze, Matthias B; Stang, Andreas; Hellwig, Kerstin; Riemann-Lorenz, Karin; Heesen, Christoph; Becher, Heiko.

In: BMC NEUROL, Vol. 24, No. 1, 13.04.2024, p. 123.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Holz, A, Obi, N, Ahrens, W, Berger, K, Bohn, B, Brenner, H, Fischer, B, Fricke, J, Führer, A, Gastell, S, Greiser, KH, Harth, V, Heise, J-K, Holleczek, B, Keil, T, Klett-Tammen, CJ, Leitzmann, M, Lieb, W, Meinke-Franze, C, Michels, KB, Mikolajczyk, R, Nimptsch, K, Peters, A, Pischon, T, Riedel, O, Schikowski, T, Schipf, S, Schmidt, B, Schulze, MB, Stang, A, Hellwig, K, Riemann-Lorenz, K, Heesen, C & Becher, H 2024, 'Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)', BMC NEUROL, vol. 24, no. 1, pp. 123. https://doi.org/10.1186/s12883-024-03620-4

APA

Holz, A., Obi, N., Ahrens, W., Berger, K., Bohn, B., Brenner, H., Fischer, B., Fricke, J., Führer, A., Gastell, S., Greiser, K. H., Harth, V., Heise, J-K., Holleczek, B., Keil, T., Klett-Tammen, C. J., Leitzmann, M., Lieb, W., Meinke-Franze, C., ... Becher, H. (2024). Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). BMC NEUROL, 24(1), 123. https://doi.org/10.1186/s12883-024-03620-4

Vancouver

Holz A, Obi N, Ahrens W, Berger K, Bohn B, Brenner H et al. Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). BMC NEUROL. 2024 Apr 13;24(1):123. https://doi.org/10.1186/s12883-024-03620-4

Bibtex

@article{9beb2d7a219745fd9fb6cd94f2d94f57,
title = "Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)",
abstract = "BACKGROUND: Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.METHODS: Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.RESULTS: Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.CONCLUSIONS: Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.",
author = "Anja Holz and Nadia Obi and Wolfgang Ahrens and Klaus Berger and Barbara Bohn and Hermann Brenner and Beate Fischer and Julia Fricke and Amand F{\"u}hrer and Sylvia Gastell and Greiser, {Karin Halina} and Volker Harth and Jana-Kristin Heise and Bernd Holleczek and Thomas Keil and Klett-Tammen, {Carolina J} and Michael Leitzmann and Wolfgang Lieb and Claudia Meinke-Franze and Michels, {Karin B} and Rafael Mikolajczyk and Katharina Nimptsch and Annette Peters and Tobias Pischon and Oliver Riedel and Tamara Schikowski and Sabine Schipf and B{\"o}rge Schmidt and Schulze, {Matthias B} and Andreas Stang and Kerstin Hellwig and Karin Riemann-Lorenz and Christoph Heesen and Heiko Becher",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
month = apr,
day = "13",
doi = "10.1186/s12883-024-03620-4",
language = "English",
volume = "24",
pages = "123",
journal = "BMC NEUROL",
issn = "1471-2377",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO)

AU - Holz, Anja

AU - Obi, Nadia

AU - Ahrens, Wolfgang

AU - Berger, Klaus

AU - Bohn, Barbara

AU - Brenner, Hermann

AU - Fischer, Beate

AU - Fricke, Julia

AU - Führer, Amand

AU - Gastell, Sylvia

AU - Greiser, Karin Halina

AU - Harth, Volker

AU - Heise, Jana-Kristin

AU - Holleczek, Bernd

AU - Keil, Thomas

AU - Klett-Tammen, Carolina J

AU - Leitzmann, Michael

AU - Lieb, Wolfgang

AU - Meinke-Franze, Claudia

AU - Michels, Karin B

AU - Mikolajczyk, Rafael

AU - Nimptsch, Katharina

AU - Peters, Annette

AU - Pischon, Tobias

AU - Riedel, Oliver

AU - Schikowski, Tamara

AU - Schipf, Sabine

AU - Schmidt, Börge

AU - Schulze, Matthias B

AU - Stang, Andreas

AU - Hellwig, Kerstin

AU - Riemann-Lorenz, Karin

AU - Heesen, Christoph

AU - Becher, Heiko

N1 - © 2024. The Author(s).

PY - 2024/4/13

Y1 - 2024/4/13

N2 - BACKGROUND: Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.METHODS: Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.RESULTS: Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.CONCLUSIONS: Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.

AB - BACKGROUND: Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk.METHODS: Data from the baseline assessment of the German National Cohort (NAKO) were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between childhood and adolescence factors and risk of MS. Analyses stratified by sex were conducted.RESULTS: Among a total of 204,273 participants, 858 reported an MS diagnosis. Male sex was associated with a decreased MS risk (HR 0.48; 95% CI 0.41-0.56), while overweight (HR 2.03; 95% CI 1.41-2.94) and obesity (HR 1.89; 95% CI 1.02-3.48) at 18 years of age compared to normal weight were associated with increased MS risk. Having been breastfed for ≤ 4 months was associated with a decreased MS risk in men (HR 0.59; 95% CI 0.40-0.86) compared to no breastfeeding. No association with MS risk was observed for the remaining factors.CONCLUSIONS: Apart from overweight and obesity at the age of 18 years, we did not observe considerable associations with MS risk. The proportion of cases that can be explained by childhood and adolescence factors examined in this study was low. Further investigations of the association between the onset of overweight and obesity in childhood and adolescence and its interaction with physical activity and MS risk seem worthwhile.

U2 - 10.1186/s12883-024-03620-4

DO - 10.1186/s12883-024-03620-4

M3 - SCORING: Journal article

C2 - 38614986

VL - 24

SP - 123

JO - BMC NEUROL

JF - BMC NEUROL

SN - 1471-2377

IS - 1

ER -