Research ExplorerPublications(Chemo)radiotherapy after laser microsurgery and selective n...

(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer

Standard

(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. / Wolff, Hendrik Andreas; Ihler, Friedrich; Zeller, Nina; Welz, Christian; Jung, Klaus; Canis, Martin; Steiner, Wolfgang.

In: EUR ARCH OTO-RHINO-L, Vol. 273, No. 6, 01.06.2016, p. 1533-41.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wolff, HA, Ihler, F, Zeller, N, Welz, C, Jung, K, Canis, M & Steiner, W 2016, '(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer', EUR ARCH OTO-RHINO-L, vol. 273, no. 6, pp. 1533-41. https://doi.org/10.1007/s00405-015-3619-4

APA

Wolff, H. A., Ihler, F., Zeller, N., Welz, C., Jung, K., Canis, M., & Steiner, W. (2016). (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. EUR ARCH OTO-RHINO-L, 273(6), 1533-41. https://doi.org/10.1007/s00405-015-3619-4

Vancouver

Wolff HA, Ihler F, Zeller N, Welz C, Jung K, Canis M et al. (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. EUR ARCH OTO-RHINO-L. 2016 Jun 1;273(6):1533-41. https://doi.org/10.1007/s00405-015-3619-4

Bibtex

@article{36a05fb6a0734f91b814d9ba6cb53cd8,
title = "(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer",
abstract = "This study analyzed the efficacy of transoral laser microsurgery and postoperative (chemo) radiotherapy (CRT) for head and neck squamous cell carcinoma. Between 1987 and 2007, 318 patients with pN2 neck disease were included. Seventy-three patients received laser resection and neck dissection alone, 154 postoperative radiotherapy, and 91 postoperative (C)RT. Mean follow-up was 58.2 ± 51.2 months, and locoregional control was significantly better after postoperative (C)RT (surgery alone: 42 %, radiotherapy: 57 %, CRT: 59 %; p < 0.01). Postoperative (C)RT did not have a significant impact on disease-specific survival (DSS) (surgery alone: 55 %, radiotherapy alone: 60 %, CRT: 64 %; p = 0.36). Fifty-seven patients (17.92 %) developed distant metastases, and 39 patients (12.26 %) presented with secondary malignancies, with no significant differences found between the treatment groups. Postoperative (C)RT significantly improved locoregional control, but had no significant effect on DSS because of high rates of secondary malignancies and distant metastases. Reduced radicality in combination with an effective screening might improve prognosis and quality of life of these patients.",
author = "Wolff, {Hendrik Andreas} and Friedrich Ihler and Nina Zeller and Christian Welz and Klaus Jung and Martin Canis and Wolfgang Steiner",
year = "2016",
month = jun,
day = "1",
doi = "10.1007/s00405-015-3619-4",
language = "English",
volume = "273",
pages = "1533--41",
journal = "EUR ARCH OTO-RHINO-L",
issn = "0937-4477",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer

AU - Wolff, Hendrik Andreas

AU - Ihler, Friedrich

AU - Zeller, Nina

AU - Welz, Christian

AU - Jung, Klaus

AU - Canis, Martin

AU - Steiner, Wolfgang

PY - 2016/6/1

Y1 - 2016/6/1

N2 - This study analyzed the efficacy of transoral laser microsurgery and postoperative (chemo) radiotherapy (CRT) for head and neck squamous cell carcinoma. Between 1987 and 2007, 318 patients with pN2 neck disease were included. Seventy-three patients received laser resection and neck dissection alone, 154 postoperative radiotherapy, and 91 postoperative (C)RT. Mean follow-up was 58.2 ± 51.2 months, and locoregional control was significantly better after postoperative (C)RT (surgery alone: 42 %, radiotherapy: 57 %, CRT: 59 %; p < 0.01). Postoperative (C)RT did not have a significant impact on disease-specific survival (DSS) (surgery alone: 55 %, radiotherapy alone: 60 %, CRT: 64 %; p = 0.36). Fifty-seven patients (17.92 %) developed distant metastases, and 39 patients (12.26 %) presented with secondary malignancies, with no significant differences found between the treatment groups. Postoperative (C)RT significantly improved locoregional control, but had no significant effect on DSS because of high rates of secondary malignancies and distant metastases. Reduced radicality in combination with an effective screening might improve prognosis and quality of life of these patients.

AB - This study analyzed the efficacy of transoral laser microsurgery and postoperative (chemo) radiotherapy (CRT) for head and neck squamous cell carcinoma. Between 1987 and 2007, 318 patients with pN2 neck disease were included. Seventy-three patients received laser resection and neck dissection alone, 154 postoperative radiotherapy, and 91 postoperative (C)RT. Mean follow-up was 58.2 ± 51.2 months, and locoregional control was significantly better after postoperative (C)RT (surgery alone: 42 %, radiotherapy: 57 %, CRT: 59 %; p < 0.01). Postoperative (C)RT did not have a significant impact on disease-specific survival (DSS) (surgery alone: 55 %, radiotherapy alone: 60 %, CRT: 64 %; p = 0.36). Fifty-seven patients (17.92 %) developed distant metastases, and 39 patients (12.26 %) presented with secondary malignancies, with no significant differences found between the treatment groups. Postoperative (C)RT significantly improved locoregional control, but had no significant effect on DSS because of high rates of secondary malignancies and distant metastases. Reduced radicality in combination with an effective screening might improve prognosis and quality of life of these patients.

U2 - 10.1007/s00405-015-3619-4

DO - 10.1007/s00405-015-3619-4

M3 - SCORING: Journal article

C2 - 25864181

VL - 273

SP - 1533

EP - 1541

JO - EUR ARCH OTO-RHINO-L

JF - EUR ARCH OTO-RHINO-L

SN - 0937-4477

IS - 6

ER -