Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide

Hauke Basedau; Thalea Oppermann; Elisa Gundelwein Silva; Kuan-Po Peng; Arne May

doi:10.1111/head.14471

Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide

Standard

Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide. / Basedau, Hauke; Oppermann, Thalea; Gundelwein Silva, Elisa; Peng, Kuan-Po ; May, Arne.

In: HEADACHE, Vol. 63, No. 3, 03.2023, p. 353-359.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Basedau, H, Oppermann, T, Gundelwein Silva, E, Peng, K-P & May, A 2023, 'Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide', HEADACHE, vol. 63, no. 3, pp. 353-359. https://doi.org/10.1111/head.14471

APA

Basedau, H., Oppermann, T., Gundelwein Silva, E., Peng, K-P., & May, A. (2023). Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide. HEADACHE, 63(3), 353-359. https://doi.org/10.1111/head.14471

Vancouver

Basedau H, Oppermann T, Gundelwein Silva E, Peng K-P , May A. Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide. HEADACHE. 2023 Mar;63(3):353-359. https://doi.org/10.1111/head.14471

Bibtex

@article{d66e55e333c648458a33d0dcc2144614,

title = "Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide",

abstract = "OBJECTIVE: We hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (HC).BACKGROUND: Functional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine. Capsaicin-induced activation of nociceptive C-fibers in the skin is mainly mediated by calcitonin gene-related peptide (CGRP) and induces cutaneous vessel dilatation and flare response.METHODS: Female patients with migraine (n = 38) and age-matched HC (n = 35) underwent DBF measurement at baseline and after topical capsaicin administration using laser speckle imaging. DBF before and after capsaicin stimulation was analyzed over ophthalmic nerve/maxillary nerve/mandibular nerve (V1/V2/V3) dermatomes and the forearm as an extracephalic control.RESULTS: Capsaicin-induced DBF increased more in the trigeminal dermatomes than on the forearm. The V1 dermatome showed a smaller increase of DBF in patients with migraine compared to HC.CONCLUSION: Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP-mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.",

author = "Hauke Basedau and Thalea Oppermann and {Gundelwein Silva}, Elisa and Kuan-Po Peng and Arne May",

note = "{\textcopyright} 2023 The Authors. Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.",

year = "2023",

month = mar,

doi = "10.1111/head.14471",

language = "English",

volume = "63",

pages = "353--359",

journal = "HEADACHE",

issn = "0017-8748",

publisher = "Wiley-Blackwell",

number = "3",

}

RIS

TY - JOUR

T1 - Characterization of trigeminal C-fiber reactivity through capsaicin-induced release of calcitonin gene-related peptide

AU - Basedau, Hauke

AU - Oppermann, Thalea

AU - Gundelwein Silva, Elisa

AU - Peng, Kuan-Po

AU - May, Arne

PY - 2023/3

Y1 - 2023/3

N2 - OBJECTIVE: We hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (HC).BACKGROUND: Functional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine. Capsaicin-induced activation of nociceptive C-fibers in the skin is mainly mediated by calcitonin gene-related peptide (CGRP) and induces cutaneous vessel dilatation and flare response.METHODS: Female patients with migraine (n = 38) and age-matched HC (n = 35) underwent DBF measurement at baseline and after topical capsaicin administration using laser speckle imaging. DBF before and after capsaicin stimulation was analyzed over ophthalmic nerve/maxillary nerve/mandibular nerve (V1/V2/V3) dermatomes and the forearm as an extracephalic control.RESULTS: Capsaicin-induced DBF increased more in the trigeminal dermatomes than on the forearm. The V1 dermatome showed a smaller increase of DBF in patients with migraine compared to HC.CONCLUSION: Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP-mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.

AB - OBJECTIVE: We hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (HC).BACKGROUND: Functional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine. Capsaicin-induced activation of nociceptive C-fibers in the skin is mainly mediated by calcitonin gene-related peptide (CGRP) and induces cutaneous vessel dilatation and flare response.METHODS: Female patients with migraine (n = 38) and age-matched HC (n = 35) underwent DBF measurement at baseline and after topical capsaicin administration using laser speckle imaging. DBF before and after capsaicin stimulation was analyzed over ophthalmic nerve/maxillary nerve/mandibular nerve (V1/V2/V3) dermatomes and the forearm as an extracephalic control.RESULTS: Capsaicin-induced DBF increased more in the trigeminal dermatomes than on the forearm. The V1 dermatome showed a smaller increase of DBF in patients with migraine compared to HC.CONCLUSION: Our results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP-mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.

U2 - 10.1111/head.14471

DO - 10.1111/head.14471

M3 - SCORING: Journal article

C2 - 36705344

VL - 63

SP - 353

EP - 359

JO - HEADACHE

JF - HEADACHE

SN - 0017-8748

IS - 3

ER -