Characterization of Single Circulating Tumor Cells
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Characterization of Single Circulating Tumor Cells. / Alix-Panabières, Catherine; Pantel, Klaus.
In: FEBS LETT, Vol. 591, No. 15, 2017, p. 2241 - 2250.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Characterization of Single Circulating Tumor Cells
AU - Alix-Panabières, Catherine
AU - Pantel, Klaus
N1 - This article is protected by copyright. All rights reserved.
PY - 2017
Y1 - 2017
N2 - "Liquid biopsy" has been introduced for the analysis of circulating tumor cells (CTCs) in the blood of cancer patients, and this new diagnostic approach has received enormous attention. CTCs are derived from primary tumors and metastatic lesions and, therefore, harbor important information on the molecular characteristics relevant to tumor progression and cancer therapy. Analyses of CTCs have paved new diagnostic avenues with obvious clinical implications for personalized medicine. Key areas of clinical applications of CTCs include detection of cancer, prediction of prognosis in patients with curable disease, monitoring systemic therapies, and stratification of patients based on the detection of therapeutic targets or resistance mechanisms. The present Review will focus on the current knowledge derived from single-cell analysis of CTCs at the DNA, RNA, and protein level and emphasise the unique opportunities for performing functional studies that aim to identify the metastasis-initiator cells in cancer patients and obtain predictive information for steering cancer therapies. This article is protected by copyright. All rights reserved.
AB - "Liquid biopsy" has been introduced for the analysis of circulating tumor cells (CTCs) in the blood of cancer patients, and this new diagnostic approach has received enormous attention. CTCs are derived from primary tumors and metastatic lesions and, therefore, harbor important information on the molecular characteristics relevant to tumor progression and cancer therapy. Analyses of CTCs have paved new diagnostic avenues with obvious clinical implications for personalized medicine. Key areas of clinical applications of CTCs include detection of cancer, prediction of prognosis in patients with curable disease, monitoring systemic therapies, and stratification of patients based on the detection of therapeutic targets or resistance mechanisms. The present Review will focus on the current knowledge derived from single-cell analysis of CTCs at the DNA, RNA, and protein level and emphasise the unique opportunities for performing functional studies that aim to identify the metastasis-initiator cells in cancer patients and obtain predictive information for steering cancer therapies. This article is protected by copyright. All rights reserved.
KW - Journal Article
KW - Review
U2 - 10.1002/1873-3468.12662
DO - 10.1002/1873-3468.12662
M3 - SCORING: Journal article
C2 - 28459503
VL - 591
SP - 2241
EP - 2250
JO - FEBS LETT
JF - FEBS LETT
SN - 0014-5793
IS - 15
ER -
