Characterization of Plasmodium infections among inhabitants of rural areas in Gabon
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Characterization of Plasmodium infections among inhabitants of rural areas in Gabon. / Woldearegai, Tamirat Gebru; Lalremruata, Albert; Nguyen, The Trong; Gmeiner, Markus; Veletzky, Luzia; Tazemda-Kuitsouc, Gildas B; Matsiegui, Pierre Blaise; Mordmüller, Benjamin; Held, Jana.
In: SCI REP-UK, Vol. 9, No. 1, 05.07.2019, p. 9784.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Characterization of Plasmodium infections among inhabitants of rural areas in Gabon
AU - Woldearegai, Tamirat Gebru
AU - Lalremruata, Albert
AU - Nguyen, The Trong
AU - Gmeiner, Markus
AU - Veletzky, Luzia
AU - Tazemda-Kuitsouc, Gildas B
AU - Matsiegui, Pierre Blaise
AU - Mordmüller, Benjamin
AU - Held, Jana
PY - 2019/7/5
Y1 - 2019/7/5
N2 - Plasmodium infections in endemic areas are often asymptomatic, can be caused by different species and contribute significantly to transmission. We performed a cross-sectional study in February/March 2016 including 840 individuals ≥ 1 year living in rural Gabon (Ngounié and Moyen-Ogooué). Plasmodium parasitemia was measured by high-sensitive, real-time quantitative PCR. In a randomly chosen subset of P. falciparum infections, gametocyte carriage and prevalence of chloroquine-resistant genotypes were analysed. 618/834 (74%) individuals were positive for Plasmodium 18S-rRNA gene amplification, of these 553 (66.3%) carried P. falciparum, 193 (23%) P. malariae, 74 (8.9%) P. ovale curtisi and 38 (4.6%) P.ovale wallikeri. Non-falciparum infections mostly presented as mixed infections. P. malariae monoinfected individuals were significantly older (median age: 60 years) than coinfected (20 years) or P. falciparum monoinfected individuals (23 years). P. falciparum gametocyte carriage was confirmed in 109/223 (48.9%) individuals, prevalence of chloroquine-resistant genotypes was high (298/336, 89%), including four infections with a new SVMNK genotype. In rural Gabon, Plasmodium infections with all endemic species are frequent, emphasizing that malaria control efforts shall cover asymptomatic infections also including non-falciparum infections when aiming for eradication.
AB - Plasmodium infections in endemic areas are often asymptomatic, can be caused by different species and contribute significantly to transmission. We performed a cross-sectional study in February/March 2016 including 840 individuals ≥ 1 year living in rural Gabon (Ngounié and Moyen-Ogooué). Plasmodium parasitemia was measured by high-sensitive, real-time quantitative PCR. In a randomly chosen subset of P. falciparum infections, gametocyte carriage and prevalence of chloroquine-resistant genotypes were analysed. 618/834 (74%) individuals were positive for Plasmodium 18S-rRNA gene amplification, of these 553 (66.3%) carried P. falciparum, 193 (23%) P. malariae, 74 (8.9%) P. ovale curtisi and 38 (4.6%) P.ovale wallikeri. Non-falciparum infections mostly presented as mixed infections. P. malariae monoinfected individuals were significantly older (median age: 60 years) than coinfected (20 years) or P. falciparum monoinfected individuals (23 years). P. falciparum gametocyte carriage was confirmed in 109/223 (48.9%) individuals, prevalence of chloroquine-resistant genotypes was high (298/336, 89%), including four infections with a new SVMNK genotype. In rural Gabon, Plasmodium infections with all endemic species are frequent, emphasizing that malaria control efforts shall cover asymptomatic infections also including non-falciparum infections when aiming for eradication.
U2 - 10.1038/s41598-019-46194-9
DO - 10.1038/s41598-019-46194-9
M3 - SCORING: Journal article
C2 - 31278305
VL - 9
SP - 9784
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -
