Research ExplorerPublicationsCharacterization of Occupational Eosinophilic Bronchitis in ...

Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms

Standard

Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms. / Wiszniewska, Marta; Dellis, Perrine; van Kampen, Vera; Suojalehto, Hille; Munoz, Xavier; Walusiak-Skorupa, Jolanta; Lindström, Irmeli; Merget, Rolph; Romero-Mesones, Christian; Sastre, Joaquin; Quirce, Santiago; Mason, Paola; Rifflart, Catherine; Godet, Julien; de Blay, Frédéric; Vandenplas, Olivier; European network for the PHenotyping of OCcupational ASthma (E-PHOCAS).

In: J ALLER CL IMM-PRACT, Vol. 9, No. 2, 02.2021, p. 937-944.e4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiszniewska, M, Dellis, P, van Kampen, V, Suojalehto, H, Munoz, X, Walusiak-Skorupa, J, Lindström, I, Merget, R, Romero-Mesones, C, Sastre, J, Quirce, S, Mason, P, Rifflart, C, Godet, J, de Blay, F, Vandenplas, O & European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) 2021, 'Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms', J ALLER CL IMM-PRACT, vol. 9, no. 2, pp. 937-944.e4. https://doi.org/10.1016/j.jaip.2020.08.056

APA

Wiszniewska, M., Dellis, P., van Kampen, V., Suojalehto, H., Munoz, X., Walusiak-Skorupa, J., Lindström, I., Merget, R., Romero-Mesones, C., Sastre, J., Quirce, S., Mason, P., Rifflart, C., Godet, J., de Blay, F., Vandenplas, O., & European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) (2021). Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms. J ALLER CL IMM-PRACT, 9(2), 937-944.e4. https://doi.org/10.1016/j.jaip.2020.08.056

Vancouver

Wiszniewska M, Dellis P, van Kampen V, Suojalehto H, Munoz X, Walusiak-Skorupa J et al. Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms. J ALLER CL IMM-PRACT. 2021 Feb;9(2):937-944.e4. https://doi.org/10.1016/j.jaip.2020.08.056

Bibtex

@article{ade79c5fe201489b9a6b0ee79b6f488f,
title = "Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms",
abstract = "BACKGROUND: Occupational eosinophilic bronchitis (OEB) has been described only as anecdotal case reports.OBJECTIVE: We investigated the clinical and inflammatory characteristics of subjects with OEB identified in a cohort of subjects who completed a specific inhalation challenge (SIC) with occupational agents.METHODS: In this retrospective multicenter study, OEB was defined by (1) a fall in FEV1 less than 15% during the SIC and the absence of nonspecific bronchial hyperresponsiveness both before and after the SIC and (2) a postchallenge increase of 3% or more in sputum eosinophils. The subjects who fulfilled these criteria were compared with 226 subjects with a negative SIC and 30 subjects with a positive SIC who failed to show baseline nonspecific bronchial hyperresponsiveness.RESULTS: An isolated increase in postchallenge sputum eosinophils was documented in 33 of 259 subjects (13%) with a negative SIC. These subjects reported significantly more often an isolated cough at work compared with the negative and positive SIC controls. When compared with positive SIC controls, the subjects with OEB experienced less frequently work-related wheezing and reported a shorter duration of symptoms at work. The sensitivity of the post-SIC increase in fractional exhaled nitric oxide in identifying OEB among subjects with a negative SIC was low, ranging from 43% to 24% using cutoff values of 8 ppb to 17.5 ppb, whereas the specificity was high (90%-97%).CONCLUSIONS: This study highlights the relevance of induced sputum analysis in the investigation of work-related asthma symptoms to identify isolated increases in sputum eosinophils that are consistent with a diagnosis of OEB.",
author = "Marta Wiszniewska and Perrine Dellis and {van Kampen}, Vera and Hille Suojalehto and Xavier Munoz and Jolanta Walusiak-Skorupa and Irmeli Lindstr{\"o}m and Rolph Merget and Christian Romero-Mesones and Joaquin Sastre and Santiago Quirce and Paola Mason and Catherine Rifflart and Julien Godet and {de Blay}, Fr{\'e}d{\'e}ric and Olivier Vandenplas and {European network for the PHenotyping of OCcupational ASthma (E-PHOCAS)}",
note = "Copyright {\textcopyright} 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.jaip.2020.08.056",
language = "English",
volume = "9",
pages = "937--944.e4",
journal = "J ALLER CL IMM-PRACT",
issn = "2213-2198",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Characterization of Occupational Eosinophilic Bronchitis in a Multicenter Cohort of Subjects with Work-Related Asthma Symptoms

AU - Wiszniewska, Marta

AU - Dellis, Perrine

AU - van Kampen, Vera

AU - Suojalehto, Hille

AU - Munoz, Xavier

AU - Walusiak-Skorupa, Jolanta

AU - Lindström, Irmeli

AU - Merget, Rolph

AU - Romero-Mesones, Christian

AU - Sastre, Joaquin

AU - Quirce, Santiago

AU - Mason, Paola

AU - Rifflart, Catherine

AU - Godet, Julien

AU - de Blay, Frédéric

AU - Vandenplas, Olivier

AU - European network for the PHenotyping of OCcupational ASthma (E-PHOCAS)

N1 - Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: Occupational eosinophilic bronchitis (OEB) has been described only as anecdotal case reports.OBJECTIVE: We investigated the clinical and inflammatory characteristics of subjects with OEB identified in a cohort of subjects who completed a specific inhalation challenge (SIC) with occupational agents.METHODS: In this retrospective multicenter study, OEB was defined by (1) a fall in FEV1 less than 15% during the SIC and the absence of nonspecific bronchial hyperresponsiveness both before and after the SIC and (2) a postchallenge increase of 3% or more in sputum eosinophils. The subjects who fulfilled these criteria were compared with 226 subjects with a negative SIC and 30 subjects with a positive SIC who failed to show baseline nonspecific bronchial hyperresponsiveness.RESULTS: An isolated increase in postchallenge sputum eosinophils was documented in 33 of 259 subjects (13%) with a negative SIC. These subjects reported significantly more often an isolated cough at work compared with the negative and positive SIC controls. When compared with positive SIC controls, the subjects with OEB experienced less frequently work-related wheezing and reported a shorter duration of symptoms at work. The sensitivity of the post-SIC increase in fractional exhaled nitric oxide in identifying OEB among subjects with a negative SIC was low, ranging from 43% to 24% using cutoff values of 8 ppb to 17.5 ppb, whereas the specificity was high (90%-97%).CONCLUSIONS: This study highlights the relevance of induced sputum analysis in the investigation of work-related asthma symptoms to identify isolated increases in sputum eosinophils that are consistent with a diagnosis of OEB.

AB - BACKGROUND: Occupational eosinophilic bronchitis (OEB) has been described only as anecdotal case reports.OBJECTIVE: We investigated the clinical and inflammatory characteristics of subjects with OEB identified in a cohort of subjects who completed a specific inhalation challenge (SIC) with occupational agents.METHODS: In this retrospective multicenter study, OEB was defined by (1) a fall in FEV1 less than 15% during the SIC and the absence of nonspecific bronchial hyperresponsiveness both before and after the SIC and (2) a postchallenge increase of 3% or more in sputum eosinophils. The subjects who fulfilled these criteria were compared with 226 subjects with a negative SIC and 30 subjects with a positive SIC who failed to show baseline nonspecific bronchial hyperresponsiveness.RESULTS: An isolated increase in postchallenge sputum eosinophils was documented in 33 of 259 subjects (13%) with a negative SIC. These subjects reported significantly more often an isolated cough at work compared with the negative and positive SIC controls. When compared with positive SIC controls, the subjects with OEB experienced less frequently work-related wheezing and reported a shorter duration of symptoms at work. The sensitivity of the post-SIC increase in fractional exhaled nitric oxide in identifying OEB among subjects with a negative SIC was low, ranging from 43% to 24% using cutoff values of 8 ppb to 17.5 ppb, whereas the specificity was high (90%-97%).CONCLUSIONS: This study highlights the relevance of induced sputum analysis in the investigation of work-related asthma symptoms to identify isolated increases in sputum eosinophils that are consistent with a diagnosis of OEB.

U2 - 10.1016/j.jaip.2020.08.056

DO - 10.1016/j.jaip.2020.08.056

M3 - SCORING: Journal article

C2 - 32920064

VL - 9

SP - 937-944.e4

JO - J ALLER CL IMM-PRACT

JF - J ALLER CL IMM-PRACT

SN - 2213-2198

IS - 2

ER -