Research ExplorerPublicationsCharacterization of electrograms associated with termination...

Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation

Standard

Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation. / Takahashi, Yoshihide; O'Neill, Mark D; Hocini, Mélèze; Dubois, Rémi; Matsuo, Seiichiro; Knecht, Sébastien; Mahapatra, Srijoy; Lim, Kang-Teng; Jaïs, Pierre; Jonsson, Anders; Sacher, Frédéric; Sanders, Prashanthan; Rostock, Thomas; Bordachar, Pierre; Clémenty, Jacques; Klein, George J; Haïssaguerre, Michel.

In: J AM COLL CARDIOL, Vol. 51, No. 10, 10, 11.03.2008, p. 1003-1010.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Takahashi, Y, O'Neill, MD, Hocini, M, Dubois, R, Matsuo, S, Knecht, S, Mahapatra, S, Lim, K-T, Jaïs, P, Jonsson, A, Sacher, F, Sanders, P, Rostock, T, Bordachar, P, Clémenty, J, Klein, GJ & Haïssaguerre, M 2008, 'Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation', J AM COLL CARDIOL, vol. 51, no. 10, 10, pp. 1003-1010. https://doi.org/10.1016/j.jacc.2007.10.056

APA

Takahashi, Y., O'Neill, M. D., Hocini, M., Dubois, R., Matsuo, S., Knecht, S., Mahapatra, S., Lim, K-T., Jaïs, P., Jonsson, A., Sacher, F., Sanders, P., Rostock, T., Bordachar, P., Clémenty, J., Klein, G. J., & Haïssaguerre, M. (2008). Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation. J AM COLL CARDIOL, 51(10), 1003-1010. [10]. https://doi.org/10.1016/j.jacc.2007.10.056

Vancouver

Takahashi Y, O'Neill MD, Hocini M, Dubois R, Matsuo S, Knecht S et al. Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation. J AM COLL CARDIOL. 2008 Mar 11;51(10):1003-1010. 10. https://doi.org/10.1016/j.jacc.2007.10.056

Bibtex

@article{5134ec7ba27645d6ad6f507aac734016,
title = "Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation",
abstract = "OBJECTIVES: This study sought to determine the characteristics of atrial electrograms predictive of slowing or termination of atrial fibrillation (AF) during ablation of chronic AF.BACKGROUND: There is growing recognition of a role for electrogram-based ablation.METHODS: Forty consecutive patients (34 male, 59 +/- 10 years) undergoing ablation for chronic AF persisting for a median of 12 months (range 1 to 84 months) were included. After pulmonary vein isolation and roof line ablation, electrogram-based ablation was performed in the left atrium and coronary sinus. Targeted electrograms were acquired in a 4-s window and characterized by: 1) percentage of continuous electrical activity; 2) bipolar voltage; 3) dominant frequency; 4) fractionation index; 5) mean absolute value of derivatives of electrograms; 6) local cycle length; and 7) presence of a temporal gradient of activation. Electrogram characteristics at favorable ablation regions, defined as those associated with slowing (a >or=6-ms increase in AF cycle length) or termination of AF were compared with those at unfavorable regions.RESULTS: The AF was terminated by electrogram-based ablation in 29 patients (73%) after targeting a total of 171 regions. Ablation at 37 (22%) of these regions was followed by AF slowing, and at 29 (17%) by AF termination. The percentage of continuous electrical activity and the presence of a temporal gradient of activation were independent predictors of favorable ablation regions (p = 0.016 and p = 0.038, respectively). Other electrogram characteristics at favorable ablation regions were not significantly different from those at unfavorable ablation regions.CONCLUSIONS: Catheter ablation at sites displaying a greater percentage of continuous activity or a temporal activation gradient is associated with slowing or termination of chronic AF.",
keywords = "Anti-Arrhythmia Agents/therapeutic use, Atrial Fibrillation/drug therapy, Catheter Ablation, Electrocardiography, Electrophysiologic Techniques, Cardiac, Female, Heart Diseases/complications, Humans, Male, Middle Aged",
author = "Yoshihide Takahashi and O'Neill, {Mark D} and M{\'e}l{\`e}ze Hocini and R{\'e}mi Dubois and Seiichiro Matsuo and S{\'e}bastien Knecht and Srijoy Mahapatra and Kang-Teng Lim and Pierre Ja{\"i}s and Anders Jonsson and Fr{\'e}d{\'e}ric Sacher and Prashanthan Sanders and Thomas Rostock and Pierre Bordachar and Jacques Cl{\'e}menty and Klein, {George J} and Michel Ha{\"i}ssaguerre",
year = "2008",
month = mar,
day = "11",
doi = "10.1016/j.jacc.2007.10.056",
language = "English",
volume = "51",
pages = "1003--1010",
journal = "J AM COLL CARDIOL",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "10",

}

RIS

TY - JOUR

T1 - Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation

AU - Takahashi, Yoshihide

AU - O'Neill, Mark D

AU - Hocini, Mélèze

AU - Dubois, Rémi

AU - Matsuo, Seiichiro

AU - Knecht, Sébastien

AU - Mahapatra, Srijoy

AU - Lim, Kang-Teng

AU - Jaïs, Pierre

AU - Jonsson, Anders

AU - Sacher, Frédéric

AU - Sanders, Prashanthan

AU - Rostock, Thomas

AU - Bordachar, Pierre

AU - Clémenty, Jacques

AU - Klein, George J

AU - Haïssaguerre, Michel

PY - 2008/3/11

Y1 - 2008/3/11

N2 - OBJECTIVES: This study sought to determine the characteristics of atrial electrograms predictive of slowing or termination of atrial fibrillation (AF) during ablation of chronic AF.BACKGROUND: There is growing recognition of a role for electrogram-based ablation.METHODS: Forty consecutive patients (34 male, 59 +/- 10 years) undergoing ablation for chronic AF persisting for a median of 12 months (range 1 to 84 months) were included. After pulmonary vein isolation and roof line ablation, electrogram-based ablation was performed in the left atrium and coronary sinus. Targeted electrograms were acquired in a 4-s window and characterized by: 1) percentage of continuous electrical activity; 2) bipolar voltage; 3) dominant frequency; 4) fractionation index; 5) mean absolute value of derivatives of electrograms; 6) local cycle length; and 7) presence of a temporal gradient of activation. Electrogram characteristics at favorable ablation regions, defined as those associated with slowing (a >or=6-ms increase in AF cycle length) or termination of AF were compared with those at unfavorable regions.RESULTS: The AF was terminated by electrogram-based ablation in 29 patients (73%) after targeting a total of 171 regions. Ablation at 37 (22%) of these regions was followed by AF slowing, and at 29 (17%) by AF termination. The percentage of continuous electrical activity and the presence of a temporal gradient of activation were independent predictors of favorable ablation regions (p = 0.016 and p = 0.038, respectively). Other electrogram characteristics at favorable ablation regions were not significantly different from those at unfavorable ablation regions.CONCLUSIONS: Catheter ablation at sites displaying a greater percentage of continuous activity or a temporal activation gradient is associated with slowing or termination of chronic AF.

AB - OBJECTIVES: This study sought to determine the characteristics of atrial electrograms predictive of slowing or termination of atrial fibrillation (AF) during ablation of chronic AF.BACKGROUND: There is growing recognition of a role for electrogram-based ablation.METHODS: Forty consecutive patients (34 male, 59 +/- 10 years) undergoing ablation for chronic AF persisting for a median of 12 months (range 1 to 84 months) were included. After pulmonary vein isolation and roof line ablation, electrogram-based ablation was performed in the left atrium and coronary sinus. Targeted electrograms were acquired in a 4-s window and characterized by: 1) percentage of continuous electrical activity; 2) bipolar voltage; 3) dominant frequency; 4) fractionation index; 5) mean absolute value of derivatives of electrograms; 6) local cycle length; and 7) presence of a temporal gradient of activation. Electrogram characteristics at favorable ablation regions, defined as those associated with slowing (a >or=6-ms increase in AF cycle length) or termination of AF were compared with those at unfavorable regions.RESULTS: The AF was terminated by electrogram-based ablation in 29 patients (73%) after targeting a total of 171 regions. Ablation at 37 (22%) of these regions was followed by AF slowing, and at 29 (17%) by AF termination. The percentage of continuous electrical activity and the presence of a temporal gradient of activation were independent predictors of favorable ablation regions (p = 0.016 and p = 0.038, respectively). Other electrogram characteristics at favorable ablation regions were not significantly different from those at unfavorable ablation regions.CONCLUSIONS: Catheter ablation at sites displaying a greater percentage of continuous activity or a temporal activation gradient is associated with slowing or termination of chronic AF.

KW - Anti-Arrhythmia Agents/therapeutic use

KW - Atrial Fibrillation/drug therapy

KW - Catheter Ablation

KW - Electrocardiography

KW - Electrophysiologic Techniques, Cardiac

KW - Female

KW - Heart Diseases/complications

KW - Humans

KW - Male

KW - Middle Aged

U2 - 10.1016/j.jacc.2007.10.056

DO - 10.1016/j.jacc.2007.10.056

M3 - SCORING: Journal article

C2 - 18325439

VL - 51

SP - 1003

EP - 1010

JO - J AM COLL CARDIOL

JF - J AM COLL CARDIOL

SN - 0735-1097

IS - 10

M1 - 10

ER -