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Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET

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Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET. / Vettermann, Franziska J; Felsberg, Jörg; Reifenberger, Guido; Hasselblatt, Martin; Forbrig, Robert; Berding, Georg; la Fougère, Christian; Galldiks, Norbert; Schittenhelm, Jens; Weis, Joachim; Albert, Nathalie L; Schüller, Ulrich.

In: CLIN NUCL MED, Vol. 43, No. 12, 12.2018, p. 895-898.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vettermann, FJ, Felsberg, J, Reifenberger, G, Hasselblatt, M, Forbrig, R, Berding, G, la Fougère, C, Galldiks, N, Schittenhelm, J, Weis, J, Albert, NL & Schüller, U 2018, 'Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET', CLIN NUCL MED, vol. 43, no. 12, pp. 895-898. https://doi.org/10.1097/RLU.0000000000002300

APA

Vettermann, F. J., Felsberg, J., Reifenberger, G., Hasselblatt, M., Forbrig, R., Berding, G., la Fougère, C., Galldiks, N., Schittenhelm, J., Weis, J., Albert, N. L., & Schüller, U. (2018). Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET. CLIN NUCL MED, 43(12), 895-898. https://doi.org/10.1097/RLU.0000000000002300

Vancouver

Vettermann FJ, Felsberg J, Reifenberger G, Hasselblatt M, Forbrig R, Berding G et al. Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET. CLIN NUCL MED. 2018 Dec;43(12):895-898. https://doi.org/10.1097/RLU.0000000000002300

Bibtex

@article{c85b1c648a5146c6b191e4a9f977967a,
title = "Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET",
abstract = "BACKGROUND: Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown.METHODS: We report on MRI and F-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-FET PET characteristics were evaluated on the basis of static F-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-FET PET data.RESULTS: MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes.CONCLUSIONS: MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas.",
keywords = "Journal Article",
author = "Vettermann, {Franziska J} and J{\"o}rg Felsberg and Guido Reifenberger and Martin Hasselblatt and Robert Forbrig and Georg Berding and {la Foug{\`e}re}, Christian and Norbert Galldiks and Jens Schittenhelm and Joachim Weis and Albert, {Nathalie L} and Ulrich Sch{\"u}ller",
year = "2018",
month = dec,
doi = "10.1097/RLU.0000000000002300",
language = "English",
volume = "43",
pages = "895--898",
journal = "CLIN NUCL MED",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET

AU - Vettermann, Franziska J

AU - Felsberg, Jörg

AU - Reifenberger, Guido

AU - Hasselblatt, Martin

AU - Forbrig, Robert

AU - Berding, Georg

AU - la Fougère, Christian

AU - Galldiks, Norbert

AU - Schittenhelm, Jens

AU - Weis, Joachim

AU - Albert, Nathalie L

AU - Schüller, Ulrich

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND: Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown.METHODS: We report on MRI and F-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-FET PET characteristics were evaluated on the basis of static F-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-FET PET data.RESULTS: MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes.CONCLUSIONS: MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas.

AB - BACKGROUND: Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown.METHODS: We report on MRI and F-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-FET PET characteristics were evaluated on the basis of static F-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-FET PET data.RESULTS: MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes.CONCLUSIONS: MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas.

KW - Journal Article

U2 - 10.1097/RLU.0000000000002300

DO - 10.1097/RLU.0000000000002300

M3 - SCORING: Journal article

C2 - 30358620

VL - 43

SP - 895

EP - 898

JO - CLIN NUCL MED

JF - CLIN NUCL MED

SN - 0363-9762

IS - 12

ER -